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32 Possible Causes for Amyloidosis, Polyclonal Hyperglobulinemia

  • Castleman Disease

    The treatment of amyloidosis secondary to CD remains to be uncertain.[] The disease is characterized by fever, weight loss, anemia, polyclonal hyperglobulinemia, splenomegaly, thrombocytosis and peripheral lymphadenopathy.[] , hypoalbuminemia, polyclonal hypergammaglobulinemia, leukocytosis, thrombocytosis or splenomegaly. 1,4 In contrast to the localized form, the clinical course of the multicentric[]

  • Primary Myelofibrosis

    Abnormalities of humoral immunity: variety of autoantibodies and circulating immune complexes may be detected and amyloidosis may develop.[] Polyclonal hyperglobulinemia may be present. Patients with sporadic idiopathic or familial pulmonary hypertension have significant marrow fibrosis.[] A variety of autoantibodies and circulating immune complexes may be detected, and amyloidosis may develop.[]

  • Hyperproteinemia

    : A Review JAHA 2012 Key learning points: Patients presenting with multiorgan derangement should be screened for amyloidosis.[] (just like hyperprotenemia) (1) hemoconc (2) inflammation (3) B-lymphocyte neoplasia how do you differentiate between inflammatory and neoplastic Hyperglobulinemia?[] More serious underlying conditions include: bone marrow problems, immune system disorders like HIV/AIDS, monoclona gammopathy, multiple myeloma, and amyloidosis.[]

  • Multicentric Castleman's Disease

    hyperglobulinemia, elevated transaminases and renal disease. 2 , 5 , 7 Dispenzieri et al. 8 analyzed the clinical spectrum of Castleman’s disease in 113 patients.[] It is quite rare to diagnose interstitial nephritis and secondary amyloidosis during the course of Castleman's disease (CD).[] Patients with MCD may reveal raised serum C-reactive protein level, polyclonal hyperglobulinemia, anemia of microcytic hypochromic nature, low albumin level, and high cholesterol[]

  • MALT Lymphoma

    Localized (primary) pulmonary amyloidosis associated with pulmonary low-grade B cell lymphoma is rarely occurred.[] Not only MALT lymphoma, but also SjS can cause secondary hyperglobulinemia. Indeed, immunoelectrophoresis-serum test showed a polyclonal pattern of hyperglobulinemia.[] Systemic amyloid light chain amyloidosis (AL amyloidosis) is usually seen in association with a plasma cell disorder.[]

  • Polyclonal Hypergammaglobulinemia

    NOS ( R77.1 ) monoclonal gammopathy (of undetermined significance) ( D47.2 ) Excludes2 transplant failure and rejection ( T86 .-) D89.0 Polyclonal hypergammaglobulinemia[] She was diagnosed with AL amyloidosis and treated with bortezomib-based chemotherapy, readily leading to the hematological response fulfilling the criteria of very good partial[] Aids in the diagnosis and monitoring of multiple myeloma, lymphocytic neoplasms, Waldenstrom's macroglobulinemia, amyloidosis, light chain deposition disease and connective[]

  • Rosai-Dorfman Disease

    DISEASE ASSOCIATIONS CHARACTERIZATION AMYLOIDOSIS Rosai-Dorfman disease and generalized AA amyloidosis: a case report.[] hyperglobulinemia.[] The typical clinical features of this disease include bilateral painless lymphadenopathy, fever, and polyclonal hyperglobulinemia.[]

  • IgG4-Related Retroperitoneal Fibrosis

    Other conditions that may simulate RPF include periaortic hematoma and amyloidosis.[] hyperglobulinemia.[] […] ureteric obstruction and either acute kidney injury or chronic kidney disease - eg, retroperitoneal abscess, periaortic haematoma, pelvic surgery, radiation therapy and amyloidosis[]

  • Hyperglobulinemic Purpura

    Other immunologic abnormalities include a polyclonal hyperglobulinemia and positive tests for cryoglobulins; these cryoglobulins may contain monoclonal IgMK proteins.[] […] after trauma: a case report and discussion of the rate of progression to systemic amyloidosis.[] NOS (R77.1) monoclonal gammopathy (of undetermined significance) (D47.2) Excludes2: transplant failure and rejection (T86.-) D89.0 Polyclonal hypergammaglobulinemia Benign[]

  • Idiopathic Cryoglobulinemia

    (see Amyloidosis, [[Amyloidosis]]): produces both distal RTA and proximal RTA Cryoglobulinemia (see Cryoglobulinemia, [[Cryoglobulinemia]]) Multiple Myeloma (see Multiple[] NOS ( R77.1 ) monoclonal gammopathy (of undetermined significance) ( D47.2 ) Excludes2 transplant failure and rejection ( T86 .-) D89.0 Polyclonal hypergammaglobulinemia[] M-protein related Sensory-Motor Axonal Demyelination More commonly IgG or IgA General patterns of neuropathy in myeloma without amyloidosis Onset: Before or after diagnosis[]

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