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254 Possible Causes for and, biogenesis, during, IN, mitosis, nucleus, organization, spindle

Did you mean: and, biogenesis, during, IN, miosis, nucleus, organization, spindle

  • Polyploidy

    National Organization for Rare Disorders (NORD) 55 Kenosia Ave., Danbury CT 06810 • (203)744-0100[rarediseases.org] Phosphorylated MEK1/2 was aberrantly located within the nucleus of primary colorectal tumors and human colon cancer cells, and oncogenic activation of Ras was sufficient to[ncbi.nlm.nih.gov] We discuss here recent results on centrosome biogenesis and the possible link between ploidy changes, centrosome aberrations and cancer.[ncbi.nlm.nih.gov] Surveys of DNA content per cell by flow cytometry indicated the existence of ploidy changes during the A. vinelandii growth cycle in rich medium.[doi.org] If mitosis is switched on, each descendant receives one replica of each parental chromosome. Mitosis is mutually exclusive with changes of ploidy.[biologydirect.biomedcentral.com] Cilia mutant cells undergo abnormal cell division with apparent defects in mitotic spindle formation, cellular spindle assembly checkpoint and centrosome amplification.[ncbi.nlm.nih.gov] Keywords Polar Body Cold Shock Normal Appearance Shock Treatment Sperm Nucleus These keywords were added by machine and not by the authors.[doi.org] The set of loci at which single-copy paralogues are retained is biased towards genes involved in ribosome biogenesis and genes that evolve slowly, consistent with the hypothesis[doi.org]

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  • Autosomal Recessive Primary Microcephaly

    It normally does not affect any other major organ systems or cause other health problems.[rarediseases.info.nih.gov] DNA Damage repair, chromosome condensation [ 39 , 52 , 58 ] MCPH2 19q13.12- q13.2 WDR62 Nucleus, cetrosomal during mitosis Not yet established, expression pattern resembles[ncbi.nlm.nih.gov] The centrosome cycle: centriole biogenesis, duplication and inherent asymmetries.[ncbi.nlm.nih.gov] Indeed, evolutionary analyses of Microcephalin and ASPM reveal evidence for positive selection during human and great ape evolution.[ncbi.nlm.nih.gov] […] the underlying genetic defect after extensive molecular screening, we could delineate a possible molecular function in chromosome segregation by the characterization of mitosis[ncbi.nlm.nih.gov] CONCLUSION: We propose that a disruption of centrosome integrity and/or spindle organization may play an important role in the development of microcephaly in MCPH2.[ncbi.nlm.nih.gov] These findings suggest microtubule organization and autophagy play critical roles in MCPH.[diginole.lib.fsu.edu] (25-50%) known as MCPH5. 2,8-23 The genetic basis of brain evolution in primates including humans, involves the ASPM gene. 24-27 The ASPM protein is mostly found in the nucleus[annsaudimed.net]

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  • Shwachman Syndrome

    neutropenia) since 1994.[nyas.org] Background Shwachman-Diamond syndrome is a rare genetic disorder involving multiple organ systems that leads to digestive problems, learning challenges and blood abnormalities[cpd.utoronto.ca] Nucleus nucleolus. Nucleus nucleoplasm. Cytoplasm cytoskeleton spindle.[abcam.com] Investigate the molecular mechanisms whereby SBDS promotes ribosome biogenesis, and 3. Elucidate the role of SBDS in hematopoiesis.[grantome.com] During the follow-up period (2.5 years) we tried suspending rHuG-CSF twice, but the absolute neutrophil count (0.18-0.31 x 10(9)/L) fell significantly and suppurative infections[ncbi.nlm.nih.gov] The nucleolus is disassembled during mitosis, 20 , 21 and, accordingly, SBDS nucleolar localization was also lost during that time.[doi.org] Hematologic features (intermittent neutropenia, anemia and thrombocytopenia), respiratory infection during the first years of life, and skeletal abnormalities were also frequently[doi.org] […] blood or blood-forming organs Anaemias or other erythrocyte disorders Pure red cell aplasia 3A70 Aplastic anaemia H00439 Shwachman-Diamond syndrome Pathway hsa03008 Ribosome biogenesis[genome.jp]

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  • Premature Chromatid Separation Trait

    Source: Online Mendelian Inheritance in Man Support Organizations Support organizations can provide help and guidance in areas such as peer matching, education and training[diseaseinfosearch.org] Just outside the nucleus are two centrosomes .[psychology.wikia.com] PEX6 GP:601498 GR-Bell Peroxisomal biogenesis disorder, complementation group 4 (3) PEX6 GP:601498 GR-Bell Peroxisomal biogenesis disorder, complementation group 6 (3) PEX7[usegalaxy.org] Despite possessing multiple genomes, only true homologous chromosomes pair during meiosis in these species.[plantcell.org] […] of non-spindle citoplasmic microtubules Active role of non-spindle microtubules in capturing eliminating chromosomes Figure 4 Chromosome elimination at male first meiotic[what-when-how.com] Part of the answer is because most organisms have homologous chromosomes .[study.com] One homologous chromosome is inherited from the organism's mother; the other is inherited from the organism's father.[en.wikipedia.org] Molecular pathology Defects of BUB1B , which encodes a kinase that is an essential component of the mitotic checkpoint–MC and required for normal mitosis progression, cause[newmedicalterms.com]

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  • Circadian Rhythm

    Related Articles Molecular Analysis of Mammalian Circadian Rhythms Steven M Reppert and and David R Weaver Annual Review of Physiology The Mammalian Circadian Timing System: Organization[doi.org] Although, the number of AVP-positive neurons was decreased in neither the supraoptic nucleus nor the paraventricular nucleus, the number of AVP-positive neurons in the SCN[ncbi.nlm.nih.gov] […] were recently shown to have light-driven oscillations in Drosophila brains ( 13 ), these findings provide further evidence of the clock’s potential to influence ribosome biogenesis[pnas.org] The Global Seasonality Score and the prevalence of subsyndromal seasonal affective disorder increased (P .05) during winter.[ncbi.nlm.nih.gov] Continuous light or darkness and circadian periodic mitosis and metabolism in C and D8 mice. Amer J Physiol. 1961; 201 :227–230. [ PubMed ] Jores A.[ncbi.nlm.nih.gov] Large, slow waves intermingle with brief bursts of activity called sleep spindles, when brain waves speed up for roughly half a second or longer.[helpguide.org] Abstract Circadian rhythms are 24-h patterns regulating behavior, organs, and cells in living organisms.[ncbi.nlm.nih.gov] The suprachiasmatic nucleus (SCN), in the ventral part of the anterior hypothalamus, orchestrates physiological and behavioral circadian rhythms.[ncbi.nlm.nih.gov]

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  • Progeria

    National Organization for Rare Disorders (NORD) 55 Kenosia Ave., Danbury CT 06810 • (203)744-0100[rarediseases.org] In certain premature-ageing syndromes, the architecture of the cell nucleus is abnormal.[doi.org] Notably, the expression of PGC-1α, a central regulator of mitochondrial biogenesis, was inhibited by progerin.[ncbi.nlm.nih.gov] However, the nucleus, which is the largest and densest organelle, has not been widely studied during cell migration through the ECM.[ncbi.nlm.nih.gov] KEYWORDS: CENP-F; Hutchinson-Gilford progeria; lamin; mitosis; progerin[ncbi.nlm.nih.gov] ASH1L : ASH1 like histone lysine methyltransferase ASL : argininosuccinate lyase ASNS : asparagine synthetase (glutamine-hydrolyzing) ASPA : aspartoacylase ASPM : abnormal spindle[ghr.nlm.nih.gov] KB Riproduci file multimediale Adaptive-Stress-Response-in-Segmental-Progeria-Resembles-Long-Lived-Dwarfism-and-Calorie-pgen.0020192.sv001.ogv 1 min 54 s, 240 180; 4,9 MB Biogenesis[commons.wikimedia.org] With aging the sleeping EEG patterns known as "sleep spindles" and "K complexes" diminish in number — and it has been suggested that this change can be used as a biomarker[benbest.com]

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  • Vinblastine

    Seaton The Journal of Organic Chemistry 1996 61 (17), 6001-6008[doi.org] These are alkaloids with a dimeric chemical structure composed of an indole nucleus (catharanthine), and a dihydroindole nucleus (vindoline), joined together.Kingdom Organic[hmdb.ca] "Biogenesis of Strychnos, Aspidosperma, and Iboga alkaloids. The structure and reactions of preakuammicine." J Am Chem Soc 91(21);5874-6.[metacyc.org] […] herein a case of Vinblastine (VBL) accidental overdose, the cause of mistake, the toxic effect and the salvage therapy adopted in a young lady suffering of Hodgkin relapse during[ncbi.nlm.nih.gov] […] the control. 5HPP-33 treatment reduced the distance between the two poles of a bipolar spindle, induced multipolarity in some of the treated cells, and blocked cells at mitosis[ncbi.nlm.nih.gov] Dose-response studies further indicate that enhanced microtubule detachment from spindle poles correlate best with cytotoxicity.[en.wikipedia.org] Before a cell divides, every chromosome in the nucleus is replicated, enabling each daughter cell to have an identical set of chromosomes.[healdove.com] Abstract This is the third case, reported in the literature, of transient cortical blindness that occurred during treatment of testicular carcinoma with cisplatinum, vinblastine[ncbi.nlm.nih.gov]

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  • Autosomal Recessive Primary Microcephaly 12

    Source: Online Mendelian Inheritance in Man Support Organizations Support organizations can provide help and guidance in areas such as peer matching, education and training[diseaseinfosearch.org] (25-50%) known as MCPH5. 2,8-23 The genetic basis of brain evolution in primates including humans, involves the ASPM gene. 24-27 The ASPM protein is mostly found in the nucleus[annsaudimed.net] Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy. Nat. Genet. 46, 1283-1292.[cmmc-uni-koeln.de] Ideal for quick reference during practice, it covers the process of diagnosis, investigation, management, and counselling for patients.[books.google.de] BMC Neurology , Oct 2011 Background Autosomal recessive primary microcephaly is a disorder of neurogenic mitosis that causes reduction in brain size.[paperity.org] PMID 17090670 The microcephaly ASPM gene is expressed in proliferating tissues and encodes for a mitotic spindle protein.[atlasgeneticsoncology.org] The anomalies are organized by anatomical system and presented in a consistent manner, including details of the clinical presentation, epidemiology, embryology, treatment[books.google.de] Considering that condensin II participates in an early stage of prophase chromosome condensation within the nucleus [Ono et al., 2004], this result is indeed surprising as[karger.com]

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  • Zika Virus Disease

    KEYWORDS: Centers for Disease Control and Prevention; European Centre for Disease Control and Prevention; Pan American Health Organization; Singapore; Singapore Ministry of[ncbi.nlm.nih.gov] Whereas DNA vaccines need to get into the nucleus of the cell, mRNA vaccines only need to get into the cytoplasm, says Ripley Ballou, Vice-President Vaccines at GSK.[doi.org] Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy. Nat Genet. 2014;46:1283–92.[doi.org] Interim Guidelines for Pregnant Women During a Zika Virus Outbreak — United States, 2016. MMWR Morb Mortal Wkly Rep 2016;65:30–33. DOI: .[doi.org] The endoplasmic reticulum provides the membrane platform for biogenesis of the flavivirus replication complex. J Virol 2010 ;84: 10438 - 10447 17.[doi.org] Kriegstein , Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia , Cell Stem Cell , 20 , 4 , ([doi.org] Bruce Aylward, the organization’s head of emergency response, said at a news conference in Geneva.[nytimes.com] Hoechst 33258 dye was used to stain the nucleus. Preparations were examined with a Zeiss Apotome/Axioimager device.[doi.org]

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  • Mitochondrial Disease

    KEYWORDS: Heart transplant; Kidney transplant; Liver transplant; Mitochondrial disease; Solid organ transplant[ncbi.nlm.nih.gov] The main changes were in the dentate nucleus.[doi.org] […] of translation by cycloheximide, or of autophagy by lithium chloride, rescued viability, preserved cellular respiratory capacity and induced mitochondrial translation and biogenesis[ncbi.nlm.nih.gov] We report the use of general anesthesia 7 times in 6 adult patients with mitochondrial disease during 2004-2014.[ncbi.nlm.nih.gov] , the process of mitochondrial segregation occurs in a random manner and is much less organized than the highly accurate process of nuclear chromosome segregation during mitosis[nature.com] We believe that pronuclear transfer between zygotes, as well as the recently described metaphase II spindle transfer, has the potential to prevent the transmission of mtDNA[ncbi.nlm.nih.gov] […] coenzyme Q10 biogenesis DESCRIPTION What is the definition of this disorder from the context of how it differs from a healthy state?[childneurologyfoundation.org] In one procedure, called maternal spindle transfer, doctors use standard IVF techniques to collect eggs from the affected woman.[theguardian.com]

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