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1,603 Possible Causes for and, biogenesis, during, mitosis, organization, spindle

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  • Autosomal Recessive Primary Microcephaly

    The centrosome cycle: centriole biogenesis, duplication and inherent asymmetries.[ncbi.nlm.nih.gov] Indeed, evolutionary analyses of Microcephalin and ASPM reveal evidence for positive selection during human and great ape evolution.[ncbi.nlm.nih.gov] […] the underlying genetic defect after extensive molecular screening, we could delineate a possible molecular function in chromosome segregation by the characterization of mitosis[ncbi.nlm.nih.gov] CONCLUSION: We propose that a disruption of centrosome integrity and/or spindle organization may play an important role in the development of microcephaly in MCPH2.[ncbi.nlm.nih.gov] It normally does not affect any other major organ systems or cause other health problems.[rarediseases.info.nih.gov] In MCPH patients, brain size reduced to almost one-third of its original volume due to reduced number of generated cerebral cortical neurons during embryonic neurogensis.[ncbi.nlm.nih.gov]

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  • Polyploidy

    We discuss here recent results on centrosome biogenesis and the possible link between ploidy changes, centrosome aberrations and cancer.[ncbi.nlm.nih.gov] Surveys of DNA content per cell by flow cytometry indicated the existence of ploidy changes during the A. vinelandii growth cycle in rich medium.[doi.org] If mitosis is switched on, each descendant receives one replica of each parental chromosome. Mitosis is mutually exclusive with changes of ploidy.[biologydirect.biomedcentral.com] Cilia mutant cells undergo abnormal cell division with apparent defects in mitotic spindle formation, cellular spindle assembly checkpoint and centrosome amplification.[ncbi.nlm.nih.gov] National Organization for Rare Disorders (NORD) 55 Kenosia Ave., Danbury CT 06810 • (203)744-0100[rarediseases.org] The set of loci at which single-copy paralogues are retained is biased towards genes involved in ribosome biogenesis and genes that evolve slowly, consistent with the hypothesis[doi.org]

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  • Premature Chromatid Separation Trait

    PEX6 GP:601498 GR-Bell Peroxisomal biogenesis disorder, complementation group 4 (3) PEX6 GP:601498 GR-Bell Peroxisomal biogenesis disorder, complementation group 6 (3) PEX7[usegalaxy.org] Despite possessing multiple genomes, only true homologous chromosomes pair during meiosis in these species.[plantcell.org] Mitosis is a traumatic process.[psychology.wikia.com] […] of non-spindle citoplasmic microtubules Active role of non-spindle microtubules in capturing eliminating chromosomes Figure 4 Chromosome elimination at male first meiotic[what-when-how.com] Source: Online Mendelian Inheritance in Man Support Organizations Support organizations can provide help and guidance in areas such as peer matching, education and training[diseaseinfosearch.org] Part of the answer is because most organisms have homologous chromosomes .[study.com]

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  • Vinblastine

    "Biogenesis of Strychnos, Aspidosperma, and Iboga alkaloids. The structure and reactions of preakuammicine." J Am Chem Soc 91(21);5874-6.[metacyc.org] […] herein a case of Vinblastine (VBL) accidental overdose, the cause of mistake, the toxic effect and the salvage therapy adopted in a young lady suffering of Hodgkin relapse during[ncbi.nlm.nih.gov] […] the control. 5HPP-33 treatment reduced the distance between the two poles of a bipolar spindle, induced multipolarity in some of the treated cells, and blocked cells at mitosis[ncbi.nlm.nih.gov] Dose-response studies further indicate that enhanced microtubule detachment from spindle poles correlate best with cytotoxicity.[en.wikipedia.org] Seaton The Journal of Organic Chemistry 1996 61 (17), 6001-6008[doi.org] Abstract This is the third case, reported in the literature, of transient cortical blindness that occurred during treatment of testicular carcinoma with cisplatinum, vinblastine[ncbi.nlm.nih.gov]

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  • Autosomal Recessive Primary Microcephaly 12

    Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy. Nat. Genet. 46, 1283-1292.[cmmc-uni-koeln.de] Ideal for quick reference during practice, it covers the process of diagnosis, investigation, management, and counselling for patients.[books.google.de] BMC Neurology , Oct 2011 Background Autosomal recessive primary microcephaly is a disorder of neurogenic mitosis that causes reduction in brain size.[paperity.org] PMID 17090670 The microcephaly ASPM gene is expressed in proliferating tissues and encodes for a mitotic spindle protein.[atlasgeneticsoncology.org] Source: Online Mendelian Inheritance in Man Support Organizations Support organizations can provide help and guidance in areas such as peer matching, education and training[diseaseinfosearch.org] The anomalies are organized by anatomical system and presented in a consistent manner, including details of the clinical presentation, epidemiology, embryology, treatment[books.google.de]

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  • Zika Virus Disease

    KEYWORDS: Centers for Disease Control and Prevention; European Centre for Disease Control and Prevention; Pan American Health Organization; Singapore; Singapore Ministry of[ncbi.nlm.nih.gov] Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy. Nat Genet. 2014;46:1283–92.[doi.org] Interim Guidelines for Pregnant Women During a Zika Virus Outbreak — United States, 2016. MMWR Morb Mortal Wkly Rep 2016;65:30–33. DOI: .[dx.doi.org] The endoplasmic reticulum provides the membrane platform for biogenesis of the flavivirus replication complex. J Virol 2010 ;84: 10438 - 10447 17.[doi.org] Kriegstein , Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia , Cell Stem Cell , 20 , 4 , ([doi.org] Bruce Aylward, the organization’s head of emergency response, said at a news conference in Geneva.[nytimes.com]

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  • Microcephaly

    The endoplasmic reticulum provides the membrane platform for biogenesis of the flavivirus replication complex. J Virol 2010 ;84: 10438 - 10447 17.[doi.org] RESULTS: Mothers who experienced symptoms associated with the Zika virus during pregnancy had 10 times higher odds of delivering newborns with congenital microcephaly when[ncbi.nlm.nih.gov] Depletion of the Drosophila orthologue ( asp ) causes spindle pole unfocusing during mitosis in multiple cell types.[ncbi.nlm.nih.gov] Abstract The development of a cerebral organoid culture in vitro offers an opportunity to generate human brain-like organs to investigate mechanisms of human disease that[ncbi.nlm.nih.gov] The cohesin complex is an evolutionarily conserved multi-subunit protein complex which regulates sister chromatid cohesion during mitosis and meiosis.[ncbi.nlm.nih.gov] The majority of causative genetic variants identified thus far are inherited in an autosomal recessive manner and impact key cellular pathways such as mitosis, DNA damage[ncbi.nlm.nih.gov]

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  • Zellweger Syndrome

    Peroxisome biogenesis disorders are inherited in an autosomal recessive manner and result from mutations in any of at least 12 PEX genes that encode peroxins.[ncbi.nlm.nih.gov] During the pregnancy with the affected child the maternal serum screen (MSS) showed low estriol level.[ncbi.nlm.nih.gov] Regulated division refers to the proliferation of an organelle, in response to external signals, and need not be associated with mitosis.[physrev.physiology.org] Abstract Zellweger syndrome (ZS) is a peroxisomal disorder with a multiple congenital anomalies, characterized by stereotypical facies, profound hypotonia, organ involvement[ncbi.nlm.nih.gov] Abstract The muscles of four infants with cerebro-hepato-renal (Zellweger) syndrome were studied during life and/or at necropsy.[ncbi.nlm.nih.gov] D-BF deficiency may exhibit a range of symptoms during the neonatal and early infantile periods some of which may be similar to Zellweger syndrome.[ncbi.nlm.nih.gov]

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  • Sunburn

    Sunburn remedy healing supplies: Clean washcloth (I love these organic cotton cloths ) Raw apple cider vinegar Organic coconut oil Optional: Lavender and Peppermint Essential[butterbeliever.com] The objective of this study was to assess sunburn and changes in sunburn and sun behaviors during periadolescence.[ncbi.nlm.nih.gov] […] high serum levels of 25(OH)D are associated with markedly decreased proliferation of noncancerous but high-risk epithelial calls in the colon. 189 1,25(OH) 2 D inhibits mitosis[doi.org] A novel mutation in the XPA gene associated with unusually mild clinical features in a patient who developed a spindle cell melanoma.[ncbi.nlm.nih.gov] Melanoma can cause metastases to form (malignant tumors spread from the original source) in our vital organs... Prevent skin cancer by avoiding the sun?[naturalnews.com] Correlation between protection habits during work and leisure was substantial (rs 0.5 to 0.7). Skin health knowledge was high and pro-tanning attitude moderate.[ncbi.nlm.nih.gov]

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  • Autosomal Recessive Primary Microcephaly 11

    Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy. Nat. Genet. 46, 1283-1292.[cmmc-uni-koeln.de] Over a decade has passed since the first edition of this book was published, and the revised edition fully incorporates the advances made in the field during the intervening[books.google.com] In Drosophila it is known as Asp, and it is required to maintain the structure of the centrosomal microtubule organising centre (MTOC) during mitosis [ PMID: 10073938 ].[ebi.ac.uk] These findings suggest microtubule organization, oxidative stress, and autophagy play critical roles in MCPH.[researchandinnovationweek2015.sched.com] […] dysmorphic features but have mild-to-moderate mental retardation (MR). 1 Different causes have been proposed for microcephaly including intrauterine infections, drugs taken during[jpma.org.pk] It normally does not affect any other major organ systems or cause other health problems.[rarediseases.info.nih.gov]

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