Androgens Decreased: Causes & Reasons

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Possible Causes for Androgens Decreased

Klinefelter Syndrome

Nishizawa H et al. (2002) Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein. Diabetes 51 : 2734–2741 41. [dx.doi.org]

Eur J Endocrinol 149: 601–608 40 Nishizawa H et al. (2002) Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein. [nature.com]

[…] deficiency normal to slightly decreased verbal intelligence Genetics ~80% have 47XXY ~10% have mosaic 46XY/47XXY ~10% have 48XXYY and other less frequent types These abnormal [radiopaedia.org]

Primary Male Hypogonadism

[…] also result of increased synthesis of SHBG decreased activity at receptor often as result of androgen receptor deficiency May be primary or secondary primary hypogonadism [medbullets.com]

Decreased kisspeptin signaling 3. Hyperprolactinemia 4. Hemochromatosis 5. Hypopituitarism 6. Androgenic Steroids List the causes of defective androgen action. 1. [quizlet.com]

Low androgen (e.g., testosterone ) levels are referred to as hypoandrogenism and low estrogen (e.g., estradiol ) as hypoestrogenism. [en.wikipedia.org]

Male Hypogonadism

Androgen Deficiency Symptoms Musculoskeletal – Decreased vigour and physical energy – Diminished muscle strength Sexuality – Decreased interest in sex – Reduction in frequency [slideshare.net]

Pathogenesis of the decreased androgen levels in obese men. J Clin Endocrinol Metab 1994; 79:997–1000. [link.springer.com]

In men, androgen deficiency was associated with decreases in lean body mass, muscle size, and strength while estrogen deficiency led to increases in body fat. [2minutemedicine.com]

Andropause

There are two terms used to describe this condition – PADAM (partial androgen decrease of aging men) and ADAM (androgen decrease of aging men). [hgh10.com]

Andropause includes a constellation of symptoms related to lack of androgens, including diminished libido, decreased generalized feeling of well-being, osteoporosis, and a [ncbi.nlm.nih.gov]

Decreased androgen concentrations contribute to sexual dysfunction, loss of muscle mass and function, frailty, gain of fat mass, cognitive impairment, and loss of body hair [hoodtocoasthealthcare.com]

Prolactinoma

Men may also experience a diminished libido, impotence, and infertility from decreased androgen production. [ncbi.nlm.nih.gov]

Kallmann Syndrome

The mechanism of gonadotropin secretion recovery, occurring in 8% of KS patients, is currently unknown, but androgen exposure apparently plays a role [4,25]. [tandfonline.com]

Inhibin B levels have been reported to decrease with increasing weight, which results in decreased Sertoli cells and sperm production. [en.wikipedia.org]

Apoptosis and proliferation of human testicular somatic and germ cells during prepuberty: high rate of testicular growth in newborns mediated by decreased apoptosis. J. [doi.org]

Testicular Atrophy

Targeted endocrine medical treatment of prostate cancers aims to decrease the activity of androgens on the AR, either with antiandrogens (i.e., nonsteroidal agents such as [alpfmedical.info]

Several mechanisms have been proposed to explain these findings, including a change in androgen metabolism (39), FSH and LH suppression by increased somatostatin tone, a decrease [78stepshealth.us]

Mumps Orchitis

Generated due to the decrease of androgen, androstenedione sites outside of the gonads of increased aromatic structure, coupled with the resulting increase in estrogen, resulting [tcmwell.com]

Forbes-Albright Syndrome

Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein, Diabetes, 2002, vol. 51 (pg. 2734 - 2741 ) Endogenous sex hormones and the development [molehr.oxfordjournals.org]

Sickle Cell Anemia

Zinc supplementation has also been found to decrease the incidence of infection and pain crises by correcting T helper 1 functions and cell‐mediated immunity ( Prasad 1999 [cochranelibrary.com]

[…] number of sickle‐related events in people treated with zinc sulphate and also suggested a benefit for other problems in SCD, including leg ulcers, growth, infection and androgen [cochranelibrary.com]

Chronic Alcoholism

The concept of "structural plasticity" has emerged as a potential mechanism in neurodegenerative and psychiatric diseases such as drug abuse, depression, and dementia. Chronic alcoholism is a progressive neurodegenerative disease while the person continues to abuse alcohol, though clinical and imaging studies show[…] [ncbi.nlm.nih.gov]

Chronic Kidney Insufficiency

Chronic kidney insufficiency affects a significant number of individuals in the developed countries, particularly the United States. The progressive nature of the disease and a substantial reduction in the quality of life over the period of time are the primary reasons why an early diagnosis is crucial. Anemia,[…] [symptoma.com]

Hemochromatosis

Hemochromatosis is the abnormal accumulation of iron in parenchymal organs and the most common form of iron overload disease. It may be inherited or acquired. The patients suffering from hemochromatosis have the following clinical picture. The skin of these patients acquires a bronze pigmentation due to the[…] [symptoma.com]

Spironolactone

It has a number of side effects such as gynecomastia, decreased libido, and impotence, which suggest that it also interferes with androgen action (1). [doi.org]

Eplerenone, a recently introduced selective ARA, decreases morbidity and mortality in patients with CHF following MI and has none of the androgenic or estrogenic side effects [ncbi.nlm.nih.gov]

A major action is that spironolactone inhibits androgen binding to receptor molecules in the cytosol or the nucleus of target tissues such as the skin. [ncbi.nlm.nih.gov]

Testicular Disease

OBJECTIVE: To analyze the prognostic impact of overt testicular disease (OTD) at diagnosis and role of testicular irradiation in the same. METHODS: Data of 579 boys treated at our center over 16 years was reviewed. RESULTS: Fourteen (2.4%) males had OTD. 10 (71.4%) of these had high-risk disease. Patients with[…] [ncbi.nlm.nih.gov]

Testicular Injury

J Korean Med Sci. 2017 Oct;32(10):1669-1673. doi: 10.3346/jkms.2017.32.10.1669. Author information 1 Department of Urology, School of Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul, Korea. 2 Department of Urology, School of Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee[…] [ncbi.nlm.nih.gov]

Cannabis Abuse

BACKGROUND: Cross-national differences could affect the likelihood of endorsement of DSM cannabis abuse and dependence criteria. The present study examines whether cannabis abuse and dependence criteria function differently across U.S. and Dutch cannabis users. METHOD: Data on lifetime endorsement of DSM-IV[…] [ncbi.nlm.nih.gov]

Panhypopituitarism

Suprasellar tuberculomas are exceptionally rare. We present the case of a middle aged male who presented with generalised apathy and meningism of two weeks duration. Neuroimaging was suggestive of tuberculomas in suprasellar cistern, while endocrinological investigation showed panhypopituitarism manifesting as[…] [ncbi.nlm.nih.gov]

Pituitary Cushing Syndrome

The clinical features, diagnosis and management of 16 consecutive patients with ectopic ACTH production are described and biochemical data are compared with those of 48 consecutive patients with pituitary-dependent Cushing's disease. In 10 cases the ectopic ACTH secreting tumour was completely occult to routine[…] [ncbi.nlm.nih.gov]

Gordon-Holmes Syndrome

Hayer SN 1, 2, Deconinck T 3, 4, Bender B 5, Smets K 3, 4, 6, Züchner S 7, 8, Reich S 1, 2, Schöls L 1, 2, Schüle R 1, 2, De Jonghe P 3, 4, 6, Baets J 3, 4, 6, Synofzik M 9, 10. Author information 1 Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research & Center of Neurology, University of[…] [ncbi.nlm.nih.gov]

Launois Syndrome

We report the first description of a Launois-Bensaude syndrome involving the orbit. Launois-Bensaude syndrome was diagnosed in a 70-year-old-man who presented with severe bilateral proptosis (Hertel value 26mm). We performed a bilateral transpalpebral orbital decompression by resection of intraorbital fat without[…] [ncbi.nlm.nih.gov]

Autoimmune Polyendocrine Syndrome

Abstract Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is the first multiple autoimmune disease that has been shown to be caused by mutations of a single gene named autoimmune regulator (AIRE). Fourteen different mutations of the AIRE gene have been identified in 61 patients from 55[…] [ncbi.nlm.nih.gov]

Hyperprolactinemia

OBJECTIVE: To determine the frequency of Macroprolactin (MaPRL) in patients with increased total prolactin and its clinical and financial impact. STUDY DESIGN: Cross-sectional study. PLACE AND DURATION OF STUDY: Section of Clinical Chemistry, Department of Pathology and Laboratory Medicine, The Aga Khan University[…] [ncbi.nlm.nih.gov]

Reifenstein Syndrome

These findings indicate that the syndrome results from defective androgen action rather than from decreased androgen synthesis. [ncbi.nlm.nih.gov]

[…] defect involves defective androgen action rather than decreased androgen synthesis. [nejm.org]

Studies of blood testosterone and luteinizing hormone levels in nine affected family members and of androgen and estrogen production rates in two suggest that the underlying [nejm.org]

Gynecomastia

Gynecomastia was reported to cause an imbalance between estrogen and androgen action or an increased estrogen to androgen ratio, due to increased estrogen production, decreased [ncbi.nlm.nih.gov]

However, gynecomastia can also be idiopathic. [6] Pathologic decrease of androgen or increase of estrogen can be illustrated as following: Decreased androgen action Decreased [emedicine.medscape.com]

androgen production or both. [ncbi.nlm.nih.gov]

Hereditary Thyroxine-Binding Globulin Deficiency

TBG levels can decrease with androgenic or anabolic steroids, large doses of glucocorticoids, hypoproteinemic states, liver disease, nephrotic syndrome, and congenital TBG [marshfieldlabs.org]

Estrogen increases the TBG in the serum whereas androgens and glucocorticoids decrease the TBG synthesis. [labpedia.net]

Essential Hirsutism in Women

Oral contraceptives exert their therapeutic effect by decreasing androgens and therefore sebum production. [ncbi.nlm.nih.gov]

Results: The topical Cyperus rotundus oil was significantly more effective (p Key words: Key words: Androgenic hair, Cyperus rotundus oil, Decrease hair growth, Hirsutism. [scopemed.org]

Weight loss lowers androgen levels and decreases hirsutism. Keep in mind that it will take time for any systemic approach to have an effect. [demoshealth.com]

Androgen Therapy

and androgen-dependent, generally decreasing in size after cessation of treatment. [ncbi.nlm.nih.gov]

In conclusion, this clinical trial demonstrates that androgens improve insulin sensitivity and decrease leptin levels in adult men. [care.diabetesjournals.org]

Some of the desired physical changes from oestrogen and anti-androgen therapy include decreased body and facial hair, decreased muscle mass, breast growth, and redistribution [ncbi.nlm.nih.gov]

Androgens

CONCLUSIONS: This hypothesis-free metabolomic approach found decreased serum androgens to be highly associated with DED and adds important evidence to the growing body of [ncbi.nlm.nih.gov]

decreases androgen production from cancer cells. [ncbi.nlm.nih.gov]

In fertile women both adrenals and ovaries contribute to androgen production, whereas after the menopause the ovarian contribution normally decreases. [ncbi.nlm.nih.gov]

Hyperandrogenism

Oral androgens decrease high-density lipoprotein (HDL) cholesterol and increase low-density lipoprotein (LDL) cholesterol. [emedicine.medscape.com]

These hormonal treatments have been found to reduce the androgen excess and suppress adrenal androgen production and cause a significant decrease in hirsutism. [37] [38] Hyperandrogenism [en.wikipedia.org]

SHGB levels are increased by the following: Estrogens Thyroid hormone Pregnancy Estrogen-containing preparations SHGB levels are decreased by the following: Androgens Synthetic [emedicine.medscape.com]