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16 Possible Causes for Androgens Decreased, Kallmann Syndrome, Mutation in the KISS1 Receptor Gene

  • Kallmann Syndrome

    Some key molecules have been discovered through the study of the genetics of CHH. 1 Inactivating mutations in genes encoding kisspeptin-1 ( KISS1 ) 40 and its receptor ( KISS1R[doi.org] Apoptosis and proliferation of human testicular somatic and germ cells during prepuberty: high rate of testicular growth in newborns mediated by decreased apoptosis. J.[doi.org] Kallmann syndrome is the result of a genetic defect.[symptoma.com]

  • Primary Male Hypogonadism

    gene (KISS1 receptor product)?[quizlet.com] […] also result of increased synthesis of SHBG decreased activity at receptor often as result of androgen receptor deficiency May be primary or secondary primary hypogonadism[medbullets.com] Secondary hypogonadism can be caused by Kallmann syndrome, pituitary or hypothalamic tumors or disorders, obesity, diabetes and Prader-Willi syndrome.[froedtert.com]

  • Male Hypogonadism

    gene (KISS1 receptor product)?[quizlet.com] In men, androgen deficiency was associated with decreases in lean body mass, muscle size, and strength while estrogen deficiency led to increases in body fat.[2minutemedicine.com] Disorders Causing Pituitary Hypogonadism Brain and pituitary tumors Hemochromatosis Kallmann syndrome Weight loss Obesity Diabetes Testicular Disorders Causing Hypogonadism[louisville.edu]

  • Hypogonadism

    […] in the genes encoding GNRH1 or its receptor will result in the failure of the HPG axis and give rise to normosmic CHH. [2] Inactivating mutations of KISS1 or KISS1R causes[en.wikipedia.org] Testosterone is an androgen. Production of androgens decreases slightly with age. Low levels are more common in men who are obese and have multiple health conditions.[patients.uroweb.org] BACKGROUND: Congenital hypogonadotrophic hypogonadism (CHH) and Kallmann syndrome (KS) are caused by disruption to the hypothalamic-pituitary-gonadal (H-P-G) axis.[ncbi.nlm.nih.gov]

  • Hypogonadotropic Hypogonadism Type 8

    Mutations involving the genes GnRH1 and KISS1, are a very rare cause of HH [41], [42].[journals.plos.org] Low androgen (e.g., testosterone ) levels are referred to as hypoandrogenism and low estrogen (e.g., estradiol ) as hypoestrogenism.[en.wikipedia.org] Schlüsselwörter Kallmann-Syndrom - hypogonadotroper Hypogonadismus - Anosmie - Genetik Keywords Kallmann’s syndrome - hypogonadotropic hypogonadism - anosmia - genetics[thieme-connect.com]

  • Kallmann Syndrome Type 3

    gene (KISS1 receptor product)?[quizlet.com] […] a b c d e f g h i "Kallmann syndrome".[en.wikipedia.org] Pathogenesis of the decreased androgen levels in obese men. J Clin Endocrinol Metab 1994; 79: 997-1000. 28. Schneider G, Kirschner MA, Berkowitz R, Ertel NH.[ajandrology.com]

  • Leydig Cell Hypoplasia due to LHB Deficiency

    Mutations of the GnRH1 gene have also been reported in patients with hypogonadotropic hypogonadism, although they are rare.[clinicalgate.com] syndrome and GnRH insensitivity[en.wikipedia.org] syndrome Leydig cell hypoplasia Leydig cell hypoplasia due to LHB deficiency Leydig cell hypoplasia due to complete LH resistance Leydig cell hypoplasia due to partial LH[se-atlas.de]

  • Kallmann Syndrome Type 4

    […] in the genes encoding GNRH1 or its receptor will result in the failure of the HPG axis and give rise to normosmic CHH. [2] Inactivating mutations of KISS1 or KISS1R causes[en.wikipedia.org] Other situations that may decrease the SHBG include hypothyroidism, androgen use, nephritic syndrome, Cushing’s disease, and acromegaly.[clinicaladvisor.com] Kallmann syndrome can have a wide variety of additional signs and symptoms.[ghr.nlm.nih.gov]

  • Hypogonadotropic Hypogonadism

    […] in the genes encoding GNRH1 or its receptor will result in the failure of the HPG axis and give rise to normosmic CHH. [2] Inactivating mutations of KISS1 or KISS1R causes[en.wikipedia.org] Nishizawa H et al. (2002) Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein. Diabetes 51 : 2734–2741 41.[dx.doi.org] Patients with Kallmann's syndrome or idiopathic hypogonadotropic hypogonadism usually have absent puberty.[endobible.com]

  • Hypogonadotropic Hypogonadism Type 18

    […] identified two novel missense mutations in the gene encoding the GNRH receptor ( GNRHR1 : NM_000406.2; HGNC: 4421), see Figure 2 .[journals.plos.org] Pathogenesis of the decreased androgen levels in obese men. J Clin Endocrinol Metab 1994; 79: 997-1000. 28. Schneider G, Kirschner MA, Berkowitz R, Ertel NH.[ajandrology.com] syndrome", abstract "The genetic basis is unknown for 60{\%} of normosmic hypogonadotropic hypogonadism (nHH)/Kallmann syndrome (KS).[augusta.pure.elsevier.com]