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666 Possible Causes for Anemia, Anisopoikilocytosis, Hepatosplenomegaly, Microcytic Anemia

  • Thalassemia

    They have severe anemia and hepatosplenomegaly. Untreated children have severe failure to thrive and shortened life expectancy.[] Beta-thalassemia and sickle cell anemia are two of the most common diseases related to the hemoglobin protein.[] Blood analysis shows reduced Hb levels ( 7 g/dl), mean corpuscular volume (MCV) 50 70 fl, and mean corpuscular Hb (MCH) 12 20 pg, anisopoikilocytosis and presence of erythroblasts[] On the basis of limited descriptions in the literature, the disease is reported as a mild microcytic anemia with an uncomplicated course.[]

  • Iron Deficiency Anemia

    Iron-refractory iron deficiency anemia (IRIDA) is a rare autosomal recessive disease characterized by congenital hypochromic microcytic anemia, low transferrin saturation,[] We report a case of a 14-year-old boy who presented with iron deficiency anemia, hepatosplenomegaly, geophagia and growth retardation with pubertal delay.[] Iron deficiency anemia is a common type of anemia, affecting millions of people worldwide. Iron deficiency anemia is often asymptomatic.[] Patients have hypochromic microcytic anemia refractory to oral iron and are only partially responsive to parenteral iron administration.[]

  • Myelodysplasia

    Patients have a microcytic anemia with very low transferrin saturation and are refractory to oral iron.[] An 18-month-old boy presented with fever, hepatosplenomegaly, jaundice, pancytopenia, hyperferritinemia, hypertriglyceridemia and evidence of hemophagocytosis and trilineage[] Who has aplastic anemia and MDS?[] Red cell morphology in the peripheral blood may be normal or macrocytic with anisopoikilocytosis.[]

  • Sideroblastic Anemia

    These features vary in severity and include fatigue, palpitations, pallor, dyspnea, and hepatosplenomegaly.[] Showing marked anisopoikilocytosis, basophilic stippling, polychromasia and nRBCs.[] The characteristic hypochromic, microcytic anemia typically becomes manifest in the first three decades of life.[] Patients can present at any age with symptoms of anemia or iron overload. 4, 11 Physical examination is unremarkable although mild hepatosplenomegaly may be present.[]

  • Megaloblastic Anemia

    Recently, she presented with microcytic anemia, and iron deficiency anemia was diagnosed initially.[] On physical examination, there were no remarkable findings; there was no hepatosplenomegaly.[] The present study aimed to assess the relation between obesity parameters and the occurrence of iron deficiency anemia and also megaloblastic anemia among Iranian population[] [ macrocytosis is the earliest sign in Vit B12 deficiency and can be detected even before the onset of anaemia ] - In severe anaemia in addition to macrocytosis, marked anisopoikilocytosis[]

  • Extramedullary Hematopoiesis

    The main clinical manifestations of PMF are anemia, bleeding, hepatosplenomegaly, fatigue, and fever.[] Bulky extramedullary hematopoiesis, usually detected in the thorax by imaging techniques, is a well-known complication in many types of congenital anemias.[] […] granulocyte and megakaryocytic series along with fibrillary and adipose elements Click here to view Further confirmation done by the peripheral blood film, which showed mild anisopoikilocytosis[] Her admission workup showed microcytic anemia.[]

  • Hereditary Elliptocytosis

    Structural membrane proteins were studied from erythrocytes (RBC) of a patient with a nonhemolytic form of hereditary elliptocytosis (HE) who developed a microcytic anemia[] Hepatosplenomegaly was not noted. Bone marrow revealed massive proliferation of immature plasma cells.[] Auto-immune haemolytic anemia complicating infectious mononucleosis occurred in a patient with hereditary elliptocytosis.[] Hereditary pyropoikilocytosis (HPP) is a severe, congenital hemolytic anemia occurring almost exclusively in black persons and characterized by extreme red blood cell anisopoikilocytosis[]

  • Refractory Anemia

    Hepatosplenomegaly and marked retroperitoneal lymphadenopathy were revealed, indicating further dissemination of MAI.[] For this reason, the combination therapy of recombinant human GM-CSF (rhGM-CSF) and rhEpo was performed in two patients with refractory anemia (RA) and aplastic anemia (AA[] There can also be abnormal platelets (large, giant or hypogranular) and red cell anisopoikilocytosis. Blasts are commonly present.[] Microcytic anemia refractory to usual supplementation is an important clue to an alternative diagnosis.[]

  • Iron Deficiency

    Differentiation from other microcytic anemias Iron deficiency anemia must be differentiated from other microcytic anemias (see table Differential Diagnosis of Microcytic Anemia[] ID can lead to anemia which can present with koilonychia, atrophic glossitis, fissured tongue, angular cheilitis, pica, pallor, decreased intellectual abilities, dyspnea, hepatosplenomegaly[] […] did not reveal any findings indicating the cause of the anemia.[] Video transcript - [Voiceover] Iron deficiency anemia is anemia due to a deficiency in iron, and this is a type of microcytic anemia, but that's something you already know[]

  • Congenital Dyserythropoietic Anemia

    , due to ALAS2 mutation (hypochromic microcytic anemia that develops within a few months of birth); and congenital dyserythropoietic anemia (CDA) type I , characterized by[] Congenital dyserythropoietic anemia (CDA) is a rare disorder, which manifests clinically with varying degrees of anemia and hepatosplenomegaly.[] anemia resulting in cardiac failure and relatively mild dyserythropoietic features on bone marrow aspiration in contrast to severity of anemia.[] Anisopoikilocytosis with tear-drop forms, polychromasia, basophilic stippling in peripheral blood smear, erythroid hyperplasia with megaloblastoid changes, binucleated cells[]

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