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62 Possible Causes for Anemia, Beta-2 Microglobulin Increased

  • Mantle Cell Lymphoma

    A 79-year-old woman with a 3-month history of bruising and heavy menorrhagia presented with ongoing vaginal bleeding, symptomatic anemia, and a right thigh hematoma.[ncbi.nlm.nih.gov] The 3 patients were all men, ranging from 51 to 74 years in age, and they all presented with systemic lymphadenopathy with anemia, hypoalbuminemia, elevated serum levels of[ncbi.nlm.nih.gov] The most frequent grade 3 or 4 adverse events in the temsirolimus groups were thrombocytopenia, anemia, neutropenia, and asthenia.[ncbi.nlm.nih.gov]

  • Non-Hodgkin Lymphoma

    In the first case, the laboratory tests showed anemia, thrombocytosis, elevated inflammatory biomarkers, a low level of iron, and hypoproteinemia.[ncbi.nlm.nih.gov] Beta-2-microglobulin of 3 mg/dL or more.[web.archive.org] Ki-67, mitotic index, beta-2-microglobulin) may be associated with a poorer prognosis.[ 177, 178 ] Therapeutic approaches Asymptomatic patients with low-risk scores on the[cancer.gov]

  • Chronic Lymphocytic Leukemia

    Approximately 5-10% of CLL is complicated by autoimmune cytopenia (AIC), such as autoimmune hemolytic anemia (AIHA).[ncbi.nlm.nih.gov] The multivariate Cox model indicated that del17p (P .006) and elevated beta-2-microglobulin (P .015) significantly increased the hazard ratio (HR) of progression, whereas[ncbi.nlm.nih.gov] ( 3 ) with or without lymphadenopathy, hepatomegaly, splenomegaly, or anemia.[web.archive.org]

  • Multiple Myeloma

    Therefore, when CRC is associated with refractory anemia, we should not only assume that anemia is a classical symptom of CRC, a result of chronic blood loss, nutritional[ncbi.nlm.nih.gov] In the blood of patients with multiple myeloma, the amount of beta-2-microglobulin is increased and the amount of albumin is decreased.[cancer.gov] Beta-2 microglobulin, a protein on the cell surface of myeloma and other cells; increased levels may indicate a poorer prognosis; this test may be used to help stage the disease[labtestsonline.org]

  • Cooley's Anemia

    Anemia could be severe in Cooley's anemia.[symptoma.com] .  Two studies in thalassemia -increased urinary excretion of  N-acetyl-D-glucosaminidase (NAG)  beta-2 microglobulin.  Another study from thailand (n 29 children who[de.slideshare.net] We report a case of Y. enterocolitica sepsis in a 15-year-old Taiwanese girl with Cooley's anemia and insulin-dependent diabetes mellitus.[ncbi.nlm.nih.gov]

  • Tubulointerstitial Nephritis-Uveitis Syndrome

    Blood tests showed anemia and renal insufficiency. Renal biopsy revealed interstitial nephritis and the bone marrow biopsy showed caseating granuloma.[actamedicaportuguesa.com] Combining elevated beta-2-microglobulin and elevated serum creatinine increased the PPV to 100% with an NPV of 97%.[healthylivingmagazine.us] […] normoglycemic glucosuria (3) a systemic illness lasting 2 weeks, with a combination of fever, weight loss, malaise, fatigue, rash, abdominal pain, flank pain, arthralgias, myalgias, anemia[meducator3.net]

  • Pancytopenia

    Pancytopenia is most commonly seen in aplastic anemia. In aplastic anemia, our immune system attacks the healthy cells of bone marrow.[differencebetween.net] Beta-2 microglobulin was modestly increased at 2.7 mg/L. The presence of an IgM monoclonal protein narrowed the differential substantially.[healio.com] How do you tell apart aplastic anemia and pancytopenia? A.[pathologystudent.com]

  • Waldenstrom Macroglobulinemia

    The presence of anemia with a hemoglobin value of[ncbi.nlm.nih.gov] Multivariate analysis among the 183 patients requiring therapy reaffirmed age 70 years or greater, previous nonprotocol therapy, and beta-2 microglobulin (B2M) of 3 mg/dL[ncbi.nlm.nih.gov] The most frequent adverse events   grade 3 at 15 mg were 14% anemia and 43% neutropenia. The MTD of lenalidomide is 15 mg/day 21/28 days in RRWM.[ncbi.nlm.nih.gov]

  • Amyloidosis

    CASE REPORT We present a case of gelsolin amyloidosis in a male of African descent with an atypical clinical presentation including fevers, skin rash, polyneuropathy, and anemia[ncbi.nlm.nih.gov] 2 microglobulin type : Associated with long-term hemodialysis or peritoneal dialysis; also renal failure between treatments; increases with duration of dialysis Amyloid protein[pathologyoutlines.com] A 43-year-old female with light-chain amyloidosis and concomitant multiple myeloma presented with severe bowel dysmotility causing abdominal pain, anemia, and a 100-pound[ncbi.nlm.nih.gov]

  • Acute Lymphoblastic Leukemia

    Acute leukemias affect immature cells; the disease develops rapidly, with symptoms including anemia, fever, bleeding, and swelling of the lymph nodes.[britannica.com] CD38 expression Increased Zap70 expression Elevated serum beta-2-microglobulin levels Increased serum thymidine kinase activity Short lymphocyte doubling time ( 6 mo) Increased[emedicine.com] […] children affected by acute lymphoblastic leukemia, TTP is a potentially fatal illness that should be considered in the differential diagnosis of thrombocytopenia with hemolytic anemia[ncbi.nlm.nih.gov]

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