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68 Possible Causes for Anemia, Beta-2 Microglobulin Increased

  • Mantle Cell Lymphoma

    A 79-year-old woman with a 3-month history of bruising and heavy menorrhagia presented with ongoing vaginal bleeding, symptomatic anemia, and a right thigh hematoma.[ncbi.nlm.nih.gov] The 3 patients were all men, ranging from 51 to 74 years in age, and they all presented with systemic lymphadenopathy with anemia, hypoalbuminemia, elevated serum levels of[ncbi.nlm.nih.gov] The most common grade 3 AEs were neutropenia (15%), thrombocytopenia (12%), anemia (10%), and diarrhea (3.2%).[lymphomation.org]

  • Cefotaxime

    Until recently, all cephalosporin-induced immune hemolytic anemias appeared to react by a "penicillin-type" drug adsorption mechanism, and hemolysis was extravascular.[ncbi.nlm.nih.gov] One in each group (5.3% vs 5.6%) may be considered to suffer from nephrotoxicity due to increased urinary beta(2)-microglobulin concentration.[ncbi.nlm.nih.gov] All infections were cured except for one in a patient with sickle cell anemia; this patient's illness recurred but was cured with a second course of cefotaxime followed by[ncbi.nlm.nih.gov]

  • Cladribine

    Both these agents have been associated with the onset of severe life-threatening autoimmune hemolytic anemia (AIHA) in patients with chronic lymphocytic leukemia (CLL).[ncbi.nlm.nih.gov] The multivariate Cox model indicated that del17p (P .006) and elevated beta-2-microglobulin (P .015) significantly increased the hazard ratio (HR) of progression, whereas[ncbi.nlm.nih.gov] […] against T and B lymphocytes, causing prolonged lymphopenia and linked to delayed immune complications such as opportunistic infections and more recently autoimmune hemolytic anemia[ncbi.nlm.nih.gov]

  • Balkan Nephropathy

    At least 25,000 individuals are known to have the disease. [2] Symptoms include weakness, anemia, and a coppery skin discoloration A later finding, usually after kidney failure[en.wikipedia.org] Urinary beta 2-microglobulin excretion was found increased not only in patients but in some healthy members of nephropathic families. beta 2-microglobulin therefore can serve[ncbi.nlm.nih.gov] The clinical picture that emerges is that of an insidiously progressive nephropathy with severe anemia but with only mild hypertension.[annals.org]

  • Congenital Nephrotic Syndrome Type Finnish

    However, increase of free copper was correlated to a normalization of neutrophil count, whereas anemia persisted.[bloodjournal.org] […] as shown by increased beta-2-microglobulin excretion.[ncbi.nlm.nih.gov] Clinical Characteristics General description (for patients): Kidney failure can lead to severe and fatal health problems including anemia, hypertension, malnutrition, mental[wohproject.org]

  • Chronic Lymphocytic Leukemia

    Approximately 5-10% of CLL is complicated by autoimmune cytopenia (AIC), such as autoimmune hemolytic anemia (AIHA).[ncbi.nlm.nih.gov] The multivariate Cox model indicated that del17p (P .006) and elevated beta-2-microglobulin (P .015) significantly increased the hazard ratio (HR) of progression, whereas[ncbi.nlm.nih.gov] There is no or little evidence of anemia or thrombocytopenia.[symptoma.com]

  • Pancytopenia

    Pancytopenia is most commonly seen in aplastic anemia. In aplastic anemia, our immune system attacks the healthy cells of bone marrow.[differencebetween.net] Beta-2 microglobulin was modestly increased at 2.7 mg/L. The presence of an IgM monoclonal protein narrowed the differential substantially.[healio.com] How do you tell apart aplastic anemia and pancytopenia? A.[pathologystudent.com]

  • Recombinant Interferon Gamma

    Bone marrow suppression as well as immune hemolytic anemia have been described.[ncbi.nlm.nih.gov] We report here that recombinant interferon-gamma (IFN-gamma) increases the synthesis and expression of the HLA-DR (la-like) antigens as well as beta 2-microglobulin (beta[jimmunol.org] Involvement in disease: In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [ MIM:609135].[mybiosource.com]

  • Plasmacytoma

    […] paper, we present a patient with nonsecretory multiple myeloma, who suffered from distal humerus fracture with severe bone destruction, renal failure, hypercalcemia and anemia[ncbi.nlm.nih.gov] M component, kidney dysfunction, blood calcium alterations, increased beta-2-microglobulin).[ncbi.nlm.nih.gov] Absence of lytic bone lesions, systemic involvement, anemia, high calcium levels helps in ruling out multiple myeloma .[symptoma.com]

  • Waldenstrom Macroglobulinemia

    The most frequent adverse events   grade 3 at 15 mg were 14% anemia and 43% neutropenia. The MTD of lenalidomide is 15 mg/day 21/28 days in RRWM.[ncbi.nlm.nih.gov] Poor prognosis is associated with older age (above 65 years old), hemoglobin level below 10g/dL, albumin level below 4g/dL, and increased beta-2-microglobulin level.[symptoma.com] Clinical features include anemia, thrombocytopenia, hepatosplenomegaly, lymphadenopathy, and rarely hyperviscosity.[ncbi.nlm.nih.gov]

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