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113 Possible Causes for Anemia, Bicytopenia, Thrombocytopenia

  • Paroxysmal Nocturnal Hemoglobinuria

    The combination of thrombosis, splenomegaly, and thrombocytopenia (TST) is challenging because anticoagulants are indicated but thrombocytopenia may increase the bleeding[ncbi.nlm.nih.gov] The indications included pancytopenia (all three cell lines), bicytopenia (two cell lines), and unicytopenia (one cell line).[bcmj.org] Anemia work-up revealed a misunderstood association of a hemolytic anemia with a negative direct antiglobulin test and iron deficiency.[ncbi.nlm.nih.gov]

  • Pancytopenia

    […] mm(3), and severe thrombocytopenia as thrombocyte counts below 20,000/mm(3).[ncbi.nlm.nih.gov] If more than one of the blood cells is low then the condition is called as bicytopenia.[ncbi.nlm.nih.gov] Pancytopenia is most commonly seen in aplastic anemia. In aplastic anemia, our immune system attacks the healthy cells of bone marrow.[differencebetween.net]

  • Malaria

    […] describ the case of a young soldier who, after returning from Central Africa, presented a fever associated with petechial purpura and gingivorrhagia, hemogram showed deep thrombocytopenia[ncbi.nlm.nih.gov] The prevalence of cytopenias were; 29.6, 48.0% for anemia, 38.9, 12.0% for thrombocytopenia, 20.4, 12.0% for leukopenia, 13.0, 8.0% for bicytopenia and 5.6, 4.0% for pancytopenia[ncbi.nlm.nih.gov] AL treatment of severe malaria can cause delayed hemolytic anemia.[ncbi.nlm.nih.gov]

  • Gaucher Disease

    Medical examination showed slight splenomegaly (250 62 mm), thrombocytopenia (platelets 51 109/L), anemia (Hb levels 107 g/L), and β-glucocerebrosidase activity (GBA) in leukocytes[ncbi.nlm.nih.gov] Gaucher disease is a common inborn error of metabolism leading to widespread chronic inflammation and often thrombocytopenia.[ncbi.nlm.nih.gov] A patient known for hepatosplenomegaly with hyperferritinemia, anemia, and thrombocytopenia was admitted for Lewy body dementia and bullous pemphigoid.[ncbi.nlm.nih.gov]

  • Severe Aplastic Anemia

    She recovered completely, but her thrombocytopenia persisted. Six weeks later she became pancytopenic. A bone marrow aspirate and biopsy showed severe aplastic anemia.[ncbi.nlm.nih.gov] Aplastic anemia is a rare, serious disease characterized by hypocellular bone marrow and pancytopenia in the peripheral blood.[ncbi.nlm.nih.gov] Stable mixed chimerism and mild thrombocytopenia, but no active hepatitis continued. At age 13, abdominal pain was a sign of massive tumor.[ncbi.nlm.nih.gov]

  • Castleman Disease

    The side effects, essentially sustained thrombocytopenia, were mild in both cases.[ncbi.nlm.nih.gov] Investigations showed bicytopenia, nephrotic range proteinuria with hypoalbuminemia, hypogammaglobulinemia, and features of hyaline-vascular type Castleman disease in a lymph[ncbi.nlm.nih.gov] Laboratory findings were consistent with anemia of inflammation. Direct antiglobulin test was positive without any other evidence of autoimmune anemia.[ncbi.nlm.nih.gov]

  • Primary Myelofibrosis

    Six weeks later, he developed grade 4 thrombocytopenia and grade 3 anemia.[ncbi.nlm.nih.gov] Patients with primary myelofibrosis may have pancytopenia or bicytopenia and in that respect mimic patients with oligoblastic leukemia (myelodysplasia [MDS]; see Chap. 88)[patient-help.com] Most of them had anemia, fever, and hepatosplenomegaly on admission.[ncbi.nlm.nih.gov]

  • Acute Leukemia

    A 29-year-old woman was admitted with thrombocytopenia, blast-like cells in the peripheral blood and a coagulation disorder.[ncbi.nlm.nih.gov] A 43-year-old female presented with leukocytosis and bicytopenia.[ncbi.nlm.nih.gov] Anemia (Hb 8 g/dL) is treated with transfusions of packed RBCs.[merckmanuals.com]

  • Colchicine Poisoning

    Laboratory analysis showed highly elevated blood concentrations of hepatic enzymes, creatine kinase, lactate dehydrogenase and blood urea nitrogen, as well as leukocytopenia and thrombocytopenia[ncbi.nlm.nih.gov] […] the Psychiatric Department of our hospital after recovering from a suicide attempt, apparently taking 40 pills of colchicine (40 mg), which led to severe pancreatitis and bicytopenia[ijtrichology.com] On occasion, long-term users of colchicine may develop bone marrow depression resulting in poor blood clotting, anemia or neutropenia (low levels of white blood cells).[colchicine.ca]

  • Hypersplenism

    The laparoscopic splenic vessels ligation is a feasible option for treating hypersplenism and thrombocytopenia in children.[ncbi.nlm.nih.gov] Bone marrow examination in Egyptian patients with bicytopenia/pancytopenia Somaia Mohammed Mousa Comparative Clinical Pathology (2015) 5.[nature.com] Although splenomegaly in children with sickle cell anemia is common, massive enlargement associated with thrombocytopenia and very severe anemia is rare.[jamanetwork.com]

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