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885 Possible Causes for Anemia, CREST Syndrome

  • Systemic Scleroderma

    SRC is characterized by malignant hypertension, hyperreninemia, azotemia, and microangiopathic hemolytic anemia.[ncbi.nlm.nih.gov] Scleroderma has been further subclassified into localized scleroderma (morphea), limited cutaneous systemic sclerosis (previously CREST syndrome, standing for calcinosis,[clinicaladvisor.com] The following were considered poor prognostic omens: cardiac or renal involvement, significant elevation of the erythrocyte sedimentation rate, and anemia.[ahajournals.org]

  • Diffuse Scleroderma

    Anemia preceded allograft SRC in two cases, pericardial effusion in one, and skin tightening in two others.[doi.org] This study shows that the term 'CREST syndrome' could be replaced by 'limited cutaneous systemic sclerosis'.[ncbi.nlm.nih.gov] Anemia may be a sign of gastric antral vascular ectasia (watermelon stomach).[aafp.org]

  • Primary Biliary Cirrhosis

    Autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) associated with Evans syndrome; combination of autoimmune hemolytic anemia (AIHA) and immune thrombocytopenic[ncbi.nlm.nih.gov] This case shows the association of PBC and NRH with porto pulmonary hypertension in CREST syndrome.[ncbi.nlm.nih.gov] Other diseases, such as hypothyroidism and anemia, can also develop. Progressive cirrhosis can lead to liver failure.[nlm.nih.gov]

  • Gastrointestinal Hemorrhage

    Although severe anemia can theoretically result in anemic hypoxia, vulnerable pallidal lesions have rarely been described in anemic patients.[ncbi.nlm.nih.gov] CONCLUSIONS: Patients with SSc/CREST syndrome are at risk of developing severe gastrointestinal hemorrhage.[ncbi.nlm.nih.gov] Five months after the surgery, she was re-admitted because of melena and anemia.[ncbi.nlm.nih.gov]

  • Iron Deficiency

    […] did not reveal any findings indicating the cause of the anemia.[ncbi.nlm.nih.gov] syndrome) and reported recurrent epistaxis; one had multiple medical problems, including chronic liver disease; and one with degenerative joint disease later reported having[doi.org] Go to Anemia, Sideroblastic Anemias, and Chronic Anemia for complete information on these topics.[emedicine.com]

  • Liver Cirrhosis

    Glycated hemoglobin (HbA1c) is a widely used marker of glycemic control but can be affected by hemolytic anemia.[ncbi.nlm.nih.gov] The detection of antibodies to SS-A/Ro implied concurrent Sicca syndrome in patients with PBC [ 56, 57 ], while anticentromere antibody was associated with CREST syndrome[dx.doi.org] In cirrhotic patients, lipoprotein impairment is associated with several complications: infections, malnutrition, adrenal function, and spur cell anemia.[ncbi.nlm.nih.gov]

  • Gastric Antral Vascular Ectasia

    Finding the etiology of anemia can be challenging, especially in females and elderly patients.[doi.org] syndrome.[rarediseases.info.nih.gov] syndrome Frequently associated with cirrhosis Endoscopic appearance Parallel longitudinal red stripes in antrum converging on pylorus “Watermelon stomach” Robert V Rouse[surgpathcriteria.stanford.edu]

  • Blue Rubber Bleb Nevus Syndrome

    This disease is often associated with sideropenic anemia and occult bleeding.[ncbi.nlm.nih.gov] […] hemangiomas) or malignant (Kaposi's sarcoma, angiosarcoma); vascular anomalies associated with congenital or systemic diseases (Klippel-Trenaunay-Weber, Ehlers-Danlos, the CREST[orpha.net] A 15-year-old girl presented with refractory iron-deficiency anemia (IDA) for 10 years, without any hemorrhagic signs or noticeable cutaneous lesions, which led to her obvious[ncbi.nlm.nih.gov]

  • Rheumatoid Arthritis

    Erythropoiesis-stimulating agents have been used to treat anemia, one of the extra-articular manifestations of RA.[ncbi.nlm.nih.gov] View Article PubMed Google Scholar Akiyama Y, Tanaka M, Takeishi M, Adachi D, Mimori A, Suzuki T: Clinical, serological and genetic study in patients with CREST syndrome.[doi.org] This anemia is also known as 'anemia of chronic disease' ( Agarwal 2009 ; Cartwright 1966 ; Means 1995 ; Theurl 2009 ; Masson 2011 ).[doi.org]

  • Glucagonoma

    Anemia was diagnosed in 1998.[ncbi.nlm.nih.gov] Somatostatinoma syndrome. Biochemical, morphologic and clinical features. N Engl J Med 1979; 301:285-292. Andrew A.[pathology.jhu.edu] This report describes a classic presentation consisting of dermatitis, glossitis, stomatitis, angular cheilitis, anemia, and weight loss that was associated with the finding[ncbi.nlm.nih.gov]

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