Some people with Pernicious Anemia may have an abnormally enlarged liver (hepatomegaly) or spleen (splenomegaly). … Pernicious anemia (Biermer's anemia, Addison's anemia) is a type of megaloblastic anemia, due to an inability to absorb vitamin B12 (cobalamin). … Most affected infants develop a form of anemia known as megaloblastic anemia.
Following this, a physical examination may reveal hepatomegaly or tenderness in the abdominal region. … Low-grade hemolytic anemia occurs in 70% of prosthetic heart valve recipients, and severe hemolytic anemia occurs in 3%. … […] hemolytic anemia.
Hematologic manifestations are largely nonspecific and may include fatigue, which may be due to the anemia that is occasionally observed with hypereosinophilic syndrome. … Anemia associated with the disease can manifest in fatigue and other non-specific symptoms. … Signs of myleoproliferative disorder include leukocyte precursor anemia, thrombocytopenia or thrombocytosis, in addition to tear drops and nucleated red blood cells. 
Tiredness and fatigue may be present secondary to anemia; 10% of patients with CLL will present with an autoimmune hemolytic anemia . … , or splenomegaly Stage IV: characterized by absolute lymphocytosis and thrombocytopenia ( 100,000/mm3) with or without lymphadenopathy, hepatomegaly, splenomegaly, or anemia … Physical examination In addition to localized or generalized lymphadenopathy, patients may manifest the following: Splenomegaly (30-54% of cases) Hepatomegaly (10-20% of cases
The upper limit for hepatomegaly was 140 mm, and the upper limit for splenomegaly was 120 mm. … The sideroblastic anemias are a heterogeneous group of inherited and acquired disorders characterized by anemia of varying severity and the presence of ringed sideroblasts … […] and excessive breakdown. 75.9% of the patients had hepatomegaly ( ), and 44.8% had ( ) splenomegaly.
Patients may also have concurrent alcoholic hepatitis with fever, hepatomegaly, jaundice, and anorexia. … Patients may be asymptomatic or have fatigue, pruritus, and non-jaundice skin hyperpigmentation with hepatomegaly.
After assessing the course of symptoms and their progression during the interview, a meticulous physical examination, particularly abdominal palpation, will reveal either hepatomegaly … Signs and symptoms include fever, weight loss, fatigue, anemia, and substantial swelling of the liver and spleen. … Infection is characterized by pancytopenia (anemia, thrombocytopenia, neutropenia), hepatosplenomegaly, fever, and severe immunosuppression that can lead to fatal opportunistic
Splenomegaly Negative Ph chromosome or BCR/ABL Anemia Thrombocytopenia Thrombocytosis Decreased megakaryocytes Basophilia Myelofibrosis (increased reticulin or collagen) … During the accelerated phase of disease, anemia and thrombocytopenia usually develop. … Poor-prognosis characteristics include the following clinical and laboratory factors: Older age Symptomatic presentation Poor performance status African-American descent Hepatomegaly
Later, severe anemia and cachexia become apparent. … Common symptoms in infants include enlarged liver and spleen, poor weight gain, low muscle tone, jaundice , vomiting, diarrhea , developmental delay , anemia , and poor absorption … Clinical description The disease can sometimes present in the fetus (hepatomegaly, ascitis, calcified adrenal glands), but onset more typically occurs in the first weeks of
Abdominal imaging such as ultrasound scanning, MRI, or CT may show gallstones, liver cirrhosis, and hepatomegaly. … anemia; Cooley’s anemia) Progression of Thalassaemia (Mediterranean anemia; Cooley’s anemia) Symptoms of Thalassaemia (Mediterranean anemia; Cooley’s anemia) Clinical Examination … This results in splenomegaly, hepatomegaly, and changes in the bones including frontal bossing and cortical thinning.