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391 Possible Causes for Anemia, Hepatomegaly, Massive Splenomegaly, Reticulocyte Count Decreased

  • Primary Myelofibrosis

    She also underwent splenectomy when she was 13 years old, due to massive splenomegaly, anemia and various infection disease episodes.[ncbi.nlm.nih.gov] The patient, a 62-year-old female, having had primary myelofibrosis for 13 years and a splenectomy 4 years before, was admitted because of high fever, hepatomegaly, thrombocythemia[ncbi.nlm.nih.gov] Most of them had anemia, fever, and hepatosplenomegaly on admission.[ncbi.nlm.nih.gov] , and polychromatophilia and very elevated reticulocyte counts can occur. 263,264 The antiglobulin (Coombs) test usually is negative, but red cell autoantibodies can develop[patient-help.com]

  • Myeloproliferative Disease

    Splenomegaly, sometimes massive, is a characteristic finding. Symptoms include the following: Splenic pain. Early satiety. Anemia. Bone pain. Fatigue. Fever.[northshore.org] […] mice from two independent transgenic lines and from backcrosses into either the FVB or the C57BL/6 strains succumbed to a similar disease characterized by splenomegaly, hepatomegaly[ncbi.nlm.nih.gov] Here is reported the case of an elderly woman that, after surgical intervention, showed an important anemia, leucocytosis and thrombocytopenia.[ncbi.nlm.nih.gov] Splenomegaly, hepatomegaly as well as fatigue, malaise or weight loss may appear in advanced stages.[orpha.net]

  • Leukemia

    […] tiredness and fatigue Pain in bone Fever accompanied by chills Excessive sweating especially during night hours Easy prone to infections Bleeding or bruising very easily Hepatomegaly[symptoma.com] The patient does not have an enlarged liver or spleen, anemia, or low levels of platelets.[cancer.net] Peripheral Smear Leukocytosis without other secondary cause (or despite treatment) White Blood Cell Count 20,000/mm3 Associated Anemia , Thrombocytopenia or Thrombocytosis Hepatomegaly[fpnotebook.com] If untreated, the white cell count can rise so high that blood flow slows down and anemia becomes severe.[hopkinsmedicine.org]

  • Acute Myelocytic Leukemia

    splenomegaly and occasionally lymphadenopathy; prognosis is often poor.[medical-dictionary.thefreedictionary.com] Multivariate analysis showed that grades 1 or 2 GVHD (P .008) and no hepatomegaly at diagnosis (P .014) were associated with improved relapse-free survival (RFS).[ncbi.nlm.nih.gov] However, it is not clear whether this autoantibody in AML patients induces frank hemolysis (autoimmune hemolytic anemia, AIHA), as seen in lymphoid neoplasms.[ncbi.nlm.nih.gov] The clinical presentation was similar in all three, with acute onset of hepatomegaly and thrombocytopenia in the absence of significant transaminasemia or icterus.[ncbi.nlm.nih.gov]

  • Non-Hodgkin Lymphoma

    Slow growing or indolent lymphomas usually present with lymphadenopathy, hepatomegaly, splenomegaly or different types of cytopenias.[symptoma.com] In the first case, the laboratory tests showed anemia, thrombocytosis, elevated inflammatory biomarkers, a low level of iron, and hypoproteinemia.[ncbi.nlm.nih.gov] Intermediate- and high-grade lymphomas may produce the following physical examination findings: Rapidly growing and bulky lymphadenopathy Splenomegaly Hepatomegaly Large abdominal[emedicine.medscape.com] Splenomegaly and hepatomegaly may be present.[clinicaladvisor.com]

  • Alpha Thalassemia

    Splenectomy is recommended in the setting of massive splenomegaly or hypersplenism.[clinicaladvisor.com] Concurrent alpha thalassemia might be a protective trait against significant hepatomegaly in sickle cell anaemia patients more than 60 months of age at Mulago hospital.[ncbi.nlm.nih.gov] Two hundred six patients with hypochromic microcytic anemia were evaluated for alpha thalassemia.[ncbi.nlm.nih.gov] Reticulocytes, LDH and bilirubin are increased; haptoglobin is decreased.[lecturio.com]

  • Thalassemia

    The large numbers of abnormal RBCs processed by the spleen, together with its hematopoietic response to the anemia if untreated, results in massive splenomegaly, leading to[emedicine.medscape.com] The presence of hepatomegaly was a statistically significant predictor for poor physical QOL (OR   8.5, p   0.02).[ncbi.nlm.nih.gov] Beta-thalassemia and sickle cell anemia are two of the most common diseases related to the hemoglobin protein.[ncbi.nlm.nih.gov] (NRBC) were significantly decreased, while the reticulocyte count significantly increased.[ncbi.nlm.nih.gov]

  • Congenital Dyserythropoietic Anemia

    A massive hydropic newborn born with a very severe anemia (Hb 4.8 g/dL), diffuse edema, hepatosplenomegaly, ascites, pulmonary edema and respiratory distress, and shortness[ncbi.nlm.nih.gov] Iron overload, as measured by liver iron and serum ferritin levels, was reduced substantially, liver function tests improved, and hepatomegaly decreased.[ncbi.nlm.nih.gov] anemia resulting in cardiac failure and relatively mild dyserythropoietic features on bone marrow aspiration in contrast to severity of anemia.[ncbi.nlm.nih.gov] Reticulocyte count: • decreased Diamond Blackfan anemia, drugs, marrow infiltration • increased hemolytic anemia (Rh incompatibility, hemoglobinopathy, membrane or enzyme[oncologynurseadvisor.com]

  • Hereditary Spherocytosis

    splenomegaly, clearing the suspensory ligaments of the spleen first leaves it hanging on its own weight, therefore intraoperative adjustment of the patient’s position enhances[omicsonline.org] Pallor (100%), icterus (67%), undocumented fever (28%), splenomegaly (96%) and hepatomegaly (73%) were the most frequent findings. Cholelithiasis was observed in 26%.[ncbi.nlm.nih.gov] To date only three siblings with coinheritance of sickle cell anemia (SCA) and hereditary spherocytosis (HS) have been reported.[ncbi.nlm.nih.gov] , Reticulocyte count decreased 4 MCV increased, MCHC increased, Reticulocyte count decreased 5 MCV increased, MCHC decreased, Reticulocyte count increased M2 Select Answer[medbullets.com]

  • Leukoerythroblastic Anemia

    […] chronic idiopathic myelofibrosis A chronic progressive condition characterised by panmyelosis and variable marrow fibrosis, massive splenomegaly secondary to extramedullary[medical-dictionary.thefreedictionary.com] There was no jaundice, lymphadenopathy or hepatomegaly.[ijpmonline.org] (MORE) Severe Anemia is the lack of IRON in your blood. The varying degrees are basically Anemia to Severe Anemia on a scale. Most important severe anemia is dangerous![answers.com] Decreased count - reticulocyte levels drop where there is marrow infiltration (leukaemia, myeloma, lymphoma or other malignancies) or due to marrow underactivity such as in[patient.info]

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