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1,130 Possible Causes for Anemia, Hepatosplenomegaly, Leukopenia, Monocytosis

  • Infectious Mononucleosis

    Both cases involved young adults presenting with fever, pharyngitis, lymphadenopathy, hepatosplenomegaly, and atypical lymphocytosis confirmed by serologic tests, liver biopsy[ncbi.nlm.nih.gov] Leukopenia and thrombocytopenia are not uncommon.[ncbi.nlm.nih.gov] Infectious mononucleosis (IM) is a rare cause of aplastic anemia in adults.[ncbi.nlm.nih.gov] For excessive monocyte counts more generally, see monocytosis .[en.wikipedia.org]

  • Hairy Cell Leukemia

    Abdominal discomfort is a common symptom, resulting from hepatosplenomegaly.[orpha.net] Later he developed leukopenia and pancytopenia. Bone marrow biopsies showed fibrosis.[ncbi.nlm.nih.gov] Here, we describe a patient with HCL who initially presented with pancytopenia and received a diagnosis of aplastic anemia.[ncbi.nlm.nih.gov] […] neoplastic hematopoietic disorders, such as lymphoma, myelodysplastic syndromes, multiple myeloma, aplastic anemia, severe megaloblastic anemia, severe lymphocytosis, severe monocytosis[ncbi.nlm.nih.gov]

  • Chronic Myelomonocytic Leukemia

    Hepatosplenomegaly (in most cases).[cancer.gov] Not having enough normal white blood cells (leukopenia) can lead to frequent or severe infections .[cancer.org] Here is reported the case of an elderly woman that, after surgical intervention, showed an important anemia, leucocytosis and thrombocytopenia.[ncbi.nlm.nih.gov] The diagnosis of CMML requires absolute monocytosis ( 1000/μL) in addition to other criteria outlined by the World Health Organization (WHO) classification.(1) Monocytosis[ncbi.nlm.nih.gov]

  • Aggressive Systemic Mastocytosis

    The patient was a 37-week-old male, born by caesarean section owing to hepatosplenomegaly and ascites diagnosed in utero, who exhibited extensive cutaneous and systemic manifestations[ncbi.nlm.nih.gov] In fact, bone marrow failure is associated with cytopenias and patients suffering from anemia, leukopenia, or thrombocytopenia may present with pallor, weakness, and fatigue[symptoma.com] A rapidly progressive anemia and thrombocytopenia dictated a splenectomy.[ncbi.nlm.nih.gov] Respective clinical findings (so called C-Findings) include cytopenias, osteolysis (or osteoporosis) with pathologic fractures, hepatosplenomegaly with impaired liver function[ncbi.nlm.nih.gov]

  • Primary Myelofibrosis

    The main clinical manifestations of PMF are anemia, bleeding, hepatosplenomegaly, fatigue, and fever.[ncbi.nlm.nih.gov] We found that fibrosis grade 2 and greater on a 0-3 scale was associated with clinical characteristics indicative of a more advanced disease, such as anemia, leukopenia, thrombocytopenia[ncbi.nlm.nih.gov] Most of them had anemia, fever, and hepatosplenomegaly on admission.[ncbi.nlm.nih.gov] […] malignant clone in PMF and are associated with unfavorable disease features and poor prognosis which is independent of currently established prognostic scoring system and monocytosis[ncbi.nlm.nih.gov]

  • Malaria

    A 5-year-old immunocompetent girl presented with fever, jaundice, hepatosplenomegaly and pancytopenia.[ncbi.nlm.nih.gov] Anemia, Leukopenia, and thrombocytopenia are commonly observed hematological abnormalities in malaria and typhoid patients.[ncbi.nlm.nih.gov] AL treatment of severe malaria can cause delayed hemolytic anemia.[ncbi.nlm.nih.gov] Laboratory tests showed anaemia (haemoglobin 11.4 g/dl), severe thrombocytopaenia (platelets 30 10(9)/mm(3)), leukopenia (3650/mm(3)), lymphocytopenia (650/mm(3)).[ncbi.nlm.nih.gov]

  • Leukemia

    Hepatosplenomegaly and lymphadenopathy are rare in adults with acute myelogenous leukemia, but are present in about 50% of adults with acute lymphoblastic leukemia. 12 Central[aafp.org] Common side effects of Besponsa include low levels of platelets (thrombocytopenia), low levels of certain white blood cells (neutropenia, leukopenia), infection, low levels[fda.gov] The patient does not have an enlarged liver or spleen, anemia, or low levels of platelets.[cancer.net] No other obvious cause for Leukocytosis (e.g. infection, Corticosteroid s) Step 1: Consider secondary causes based on white cell count differential Monocyte predominance (monocytosis[fpnotebook.com]

  • Gaucher Disease

    The hematologist is at the forefront of specialists to whom patients with Gaucher disease present because of cytopenia and hepatosplenomegaly.[ncbi.nlm.nih.gov] Decreased platelet counts (thrombocytopenia) as well as low hemoglobin (anemia) and decreased white blood cell counts (leukopenia) result in easy bruisability and hence black-and-blue[scientificamerican.com] A 38-year-old female patient was diagnosed with anemia for 3 years.[ncbi.nlm.nih.gov] The phenotype was unusually severe with congenital ichthyosis, hepatosplenomegaly, muscular hypotonia, myoclonus and respiratory failure.[ncbi.nlm.nih.gov]

  • Systemic Lupus Erythematosus

    Hepatosplenomegaly can come and go with disease activity.[ojrd.biomedcentral.com] Drugs causing leukopenia Some drugs may lead to leukopenia.[news-medical.net] She was diagnosed with SLE with pernicious anemia and iron deficiency anemia. The rare association of SLE with pernicious anemia was reported previously in few patients.[ncbi.nlm.nih.gov] The most common laboratory finding was anemia, found in 22 (69%) of cases.[ncbi.nlm.nih.gov]

  • Brucellosis

    Brucellosis is a systemic zoonotic infectious disease that may cause fever, fatigue, sweating, arthritis, hepatosplenomegaly, cytopenia, and lymphadenopathy.[ncbi.nlm.nih.gov] Leukopenias associated with thrombocytopenia were observed. BMA showed to be normal.[ncbi.nlm.nih.gov] Also, Coombs-positive autoimmune hemolytic anemia as a result of the disease is comparatively rare when considering the other frequent hematologic complications.[ncbi.nlm.nih.gov] Anemia and leukopenia were defined as hemoglobin levels and leukocyte counts below the standard values in terms of ages, thrombocytopenia as thrombocyte counts below 150,000[ncbi.nlm.nih.gov]

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