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298 Possible Causes for Anemia, Irinotecan, Peripheral Neuropathy

  • Adenocarcinoma of the Colon

    Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal .N Engl J Med 2004;351:337-45. 13. T. Delaunoit1, S.R. Alberts, D.J.[scielo.mec.pt] Laboratory results showed anemia and elevated CA 125 levels.[ncbi.nlm.nih.gov] Patients who received FOLFOXIRI had significantly more grade 3 and 4 toxicities, including neutropenia, stomatitis, and peripheral neuropathy.[cancer.gov]

  • Malignant Gastric Neoplasm

    Irinotecan versus non‐irinotecan‐containing regimens for advanced gastric cancer Irinotecan versus non‐irinotecan‐containing regimens for advanced gastric cancer Patient or[doi.org] She was found with severe anemia and thrombocytopenia during the third course of chemotherapy.[ncbi.nlm.nih.gov] Side effects may include: tiredness nausea and vomiting nerve damage ( peripheral neuropathy ) hair loss diarrhoea anaemia (a lack of red blood cells) weight loss skin changes[nhs.uk]

  • Cecal Adenocarcinoma

    Irinotecan 24,25 Days 1 and 8: Irinotecan 125mg/m 2 IV over 30–90 minutes. Repeat cycle every 3 weeks. OR Day 1: Irinotecan 300–350mg/m 2 IV over 30–90 minutes.[cancertherapyadvisor.com] A 23-year-old male presented with occult gastrointestinal bleeding and iron deficiency anemia.[ncbi.nlm.nih.gov] Patients who received FOLFOXIRI had significantly more grade 3 and 4 toxicities, including neutropenia, stomatitis, and peripheral neuropathy.[cancer.gov]

  • Gastric Adenocarcinoma

    ., 5-FU (5 μ M); cisplatin (0.5 μ M); irinotecan (2.5 μ M); carboplatin (5 μ M); paclitaxel (2-4 n M); and X rays (1.8 Gy)] also potentiated gastric cancer clonogenic cell[ncbi.nlm.nih.gov] A natural evolution can be traced back from gastric adenocarcinoma to megaloblastic anemia due to achlorhydria in the context of chronic infection; periodic endoscopy thus[ncbi.nlm.nih.gov] neuropathy grade 2 Inability to tolerate intravenous hydration e.g due to cardiac disease Co-morbidities (based on clinical judgement by the investigator) that in the view[clinicaltrials.gov]

  • Bronchogenic Carcinoma

    Etoposide, carboplatin, cislatin or irinotecan are recommended chemotherapeutic agents.[symptoma.com] Physical examination may be normal or may reveal Anemia, finger clubbing, enlarged lymph nodes Decreased breath sounds due to underlying malignant pleural effusion Wheezes[lecturio.com] neuropathy, acanthosis nigricans, and hypertrophic osteoarthropathy (Example: clubbing of fingers).[histopathology-india.net]

  • Paraneoplastic Syndrome

    He was then switched to cisplatin and irinotecan with good response and completed five cycles.[healio.com] Three types of paraneoplastic anemias may be described, as follows: Chronic anemia resulting from an anti-erythropoietin factor, reduction in mean red blood cell (RBC) life[emedicine.medscape.com] Abstract POEMS (peripheral neuropathy, organomegaly, endocrinopathy, M protein, skin changes) syndrome is a rare multisystem paraneoplastic disorder.[ncbi.nlm.nih.gov]

  • Multiple Myeloma

    Ishida, Hirokazu Komatsu, Hiroshi Inagaki, Atsushi Suzuki and Ryuzo Ueda, Overexpression of carboxylesterase‐2 results in enhanced efficacy of topoisomerase I inhibitor, irinotecan[doi.org] Therefore, when CRC is associated with refractory anemia, we should not only assume that anemia is a classical symptom of CRC, a result of chronic blood loss, nutritional[ncbi.nlm.nih.gov] The mechanism of the development of the peripheral neuropathy is poorly understood.[ncbi.nlm.nih.gov]

  • Thiamine Deficiency

    A 67-year-old woman with colon cancer receiving ramucirumab in combination with second-line fluorouracil with folinic acid and irinotecan. Her PS was 1.[ncbi.nlm.nih.gov] […] with subacute gait instability associated with painful dysesthesias and clumsiness in both hands. 10 years before presentation he had received a diagnosis of megaloblastic anemia[ncbi.nlm.nih.gov] […] degeneration and peripheral neuropathy.[ncbi.nlm.nih.gov]

  • Esophageal Carcinoma

    Enzinger PC, Clark J, Bryan D et al. (2004) Phase II study of docetaxel, cisplatin, and irinotecan in advanced esophageal and gastric cancer.[springermedizin.de] Carcinoma of the Esophagus • Predisposing factors • Men women • Achalasia (polypoid mass in middle or distal third) • Asbestosis • Plummer-Vinson syndrome (iron deficiency anemia[learningradiology.com] […] characterized by hyperkeratosis of the palms and soles and leukoplakia in the mouth), Plummer-Vinson syndrome (a condition occurring in patients with long-standing iron-deficiency anemia[pathologystudent.com]

  • Orthostatic Hypotension

    […] very common indapamide Orthostatic hypotension: postmarketing irbesartan Orthostatic hypotension: uncommon, common irbesartan-hydrochlorothiazide Orthostatic hypotension irinotecan[sideeffects.embl.de] The case of a patient who developed aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension simultaneously during treatment with trimethoprim-sulfamethoxazole[ncbi.nlm.nih.gov] neuropathies including amyloid or diabetic neuropathy.[ncbi.nlm.nih.gov]

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