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27 Possible Causes for Anemia, Pancytopenia, Polyclonal Hyperglobulinemia

  • Primary Myelofibrosis

    The main adverse effects of ruxolitinib are anemia and thrombocytopenia.[merck.com] This is then followed by pancytopenia (a reduction in the number of red and white blood cells, as well as platelets).[aoporphan.com] Polyclonal hyperglobulinemia may be present. Patients with sporadic idiopathic or familial pulmonary hypertension have significant marrow fibrosis.[patient-help.com]

  • Multicentric Castleman's Disease

    Case 1: A 57-year-old woman had fever, anemia, anasarca, and some small cervical lymphadenopathy.[ncbi.nlm.nih.gov] Diffuse lymph-node enlargement, splenomegaly and pancytopenia were detected. Induction with Rituximab was made because pancytopenia was present.[ncbi.nlm.nih.gov] hyperglobulinemia, elevated transaminases and renal disease. 2 , 5 , 7 Dispenzieri et al. 8 analyzed the clinical spectrum of Castleman’s disease in 113 patients.[pagepress.org]

  • Congenital Intrinsic Factor Deficiency

    Few cases with his particular mutation and megaloblastic anemia have been reported.[paper.researchbib.com] Gene GIF (AR) Diagnostic Test Plasma Vitamin B12, Folate Neurological Ataxia, dystonia Non-Neurological Megaloblastic anemia, pancytopenia Treatment HydroxyCobalamin Level[treatable-id.org] NOS (R77.1) monoclonal gammopathy (of undetermined significance) (D47.2) Excludes2: transplant failure and rejection (T86.-) D89.0 Polyclonal hypergammaglobulinemia Benign[en.wikisource.org]

  • Posthemorrhagic Anaemia of the Newborn

    NOS (R77.1) monoclonal gammopathy (of undetermined significance) (D47.2) Excludes2: transplant failure and rejection (T86.-) D89.0 Polyclonal hypergammaglobulinemia Benign[en.wikisource.org] […] posthemorrhagic anemia of newborn anemia of the newborn due to hemorrhage, such as into the placenta or from umbilical vessels; it may range from mild to severe.[medicine.academic.ru] […] with malformations 284.1 Pancytopenia Excludes: pancytopenia (due to) (with): aplastic anemia NOS (284.9) bone marrow infiltration (284.2) constitutional red blood cell aplasia[theodora.com]

  • Castleman Disease

    The disease is characterized by fever, weight loss, anemia, polyclonal hyperglobulinemia, splenomegaly, thrombocytosis and peripheral lymphadenopathy.[ncbi.nlm.nih.gov] Laboratory findings were consistent with anemia of inflammation. Direct antiglobulin test was positive without any other evidence of autoimmune anemia.[ncbi.nlm.nih.gov] There is often significant anemia which may be hemolytic, often reflecting pancytopenia or hemophagocytic syndrome (Stebbing 2009).[hivbook.com]

  • HIV Infection

    If men have low testosterone levels plus fatigue, anemia, and/or muscle loss, they may be given testosterone by injection or through patches placed on the skin.[merckmanuals.com] […] osteomalacia* Protease inhibitors with statins: myopathy Hematologic or oncologic Anemia of chronic disease Lymphoma, multiple myeloma Bone marrow infiltration (leading to pancytopenia[aafp.org] Hyperactivation is reflected in dramatic polyclonal hyperglobulinemia, only a portion of which is directed against HIV antigens;(59) bone marrow plasmacytosis;(60) heightened[hivinsite.ucsf.edu]

  • Angioimmunoblastic Lymphadenopathy

    During hospitalization the patient developed hemolytic anemia (Coombs positive) and lung metastases.[ncbi.nlm.nih.gov] Laboratory findings included progressive pancytopenia, hyperuricemia, and acute renal failure. Bone marrow biopsy showed a T cell lymphoid neoplasm that had ...[citeulike.org] In one series, other symptoms included weight loss (58%), hepatomegaly (60%), polyclonal hyperglobulinemia (65%), and generalized adenopathy (87%).[emedicine.medscape.com]

  • MALT Lymphoma

    Not only MALT lymphoma, but also SjS can cause secondary hyperglobulinemia. Indeed, immunoelectrophoresis-serum test showed a polyclonal pattern of hyperglobulinemia.[ncbi.nlm.nih.gov] Autoimmune neutropenia (AIN), resulting from granulocyte-specific autoantibodies, is much less frequent than other autoimmune hematologic disorders including autoimmune hemolytic anemia[ncbi.nlm.nih.gov] In the entire collective, three cases (6%) of prolonged pancytopenia including manifest myelodysplastic syndrome in one patient (2%), three cases (6%) of secondary lymphoid[ncbi.nlm.nih.gov]

  • Pediatric Chronic Granulomatous Disease

    Hematological manifestations such as thrombocytopenia and hemolytic anemia are the most common presentations.[ncbi.nlm.nih.gov] He developed pancytopenia, hypofibrinogenemia, transaminitis, and elevated ferritin of 11 783 ng/mL.[pediatrics.aappublications.org] Polyclonal hyperglobulinemia 3. Elevated acute phase reactants such as ESR or CRP 4. Normal studies of T and B lymphocyte immunity Diagnostic test 1.[clinicalmolecularallergy.biomedcentral.com]

  • Hemolytic Anemia due to a Disorder of Glycolytic Enzymes

    anemia and congenital hemolytic anemia.[malacards.org] […] and thrombotic emboli (e.g., infarctions, Budd-Chiari syndrome ) Risk of acute leukemias Think of PNH if a patient presents with hemolytic anemia, venous thrombosis, and pancytopenia[amboss.com] NOS (R77.1) monoclonal gammopathy (of undetermined significance) (D47.2) Excludes2: transplant failure and rejection (T86.-) D89.0 Polyclonal hypergammaglobulinemia Benign[en.wikisource.org]

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