Anhidrosis: Causes & Reasons

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Possible Causes for Anhidrosis

Fabry Disease

Six patients sought consultation because of anhidrosis, considered of unclear cause, and angiokeratomas diagnosed as petechiae. [ncbi.nlm.nih.gov]

Dermal manifestations of Fabry disease include cutaneous vascular lesions (angiokeratomas) and abnormal sweating (anhidrosis or, more commonly, hypohidrosis). [emedicine.medscape.com]

Anhidrosis or hypohidrosis may occur causing heat and exercise intolerance. [orpha.net]

Thallium Poisoning

[…] poisoning, Mees lines (transverse white lines on the nails) appear in the nail plate. [22] Other dermatologic findings include crusted eczematous lesions, hypohidrosis, anhidrosis [emedicine.medscape.com]

[…] nails) appear in the nail plate. [22] Other dermatologic findings include well-demarcated hyperkeratosis of the palms and soles, crusted eczematous lesions, hypohidrosis, anhidrosis [emedicine.medscape.com]

Other findings may include crusted eczematous lesions, hypohidrosis (reduced sweating), anhidrosis (absence of sweating), palmar erythema, painful glossitis (sore tongue) [dermnetnz.org]

Brachial Plexus Injury

[…] commonly in brachial plexus injuries, resulting, respectively, in ipsilateral diaphragmatic paralysis and Horner syndrome (miosis, partial ptosis, slight enophthalmos and anhidrosis [pedsinreview.aappublications.org]

Review Topic QID: 4750 1 The injury has likely resulted in the avulsion of several nerve roots 2 Physical exam would likely reveal drooping of his left eyelid and anhidrosis [orthobullets.com]

Avulsion or damage of the C8 and T1 nerve roots from which the cervical sympathetic chain arises cause Horner syndrome, which is characterized by ptosis, meiosis, anhidrosis [thenerve.net]

Lumbosacral Plexus Disorder

Earlier in the course of autonomic neuropathy, patients might notice reduced or absent sweating (i.e., anhidrosis) often in a distal-to-proximal gradient. [clevelandclinicmeded.com]

This is most often secondary to anhidrosis in the limbs and thorax and reflects compensatory hyperhidrosis in the restricted areas that maintain normal sweating. [clevelandclinicmeded.com]

Hereditary ATTR Amyloidosis

Other system involvement Autonomic nervous system involvement includes anhidrosis, sexual impotence, disturbances of gastrointestinal motility (most commonly diarrhea alternating [ncbi.nlm.nih.gov]

Autonomic Neuropathy

1型遺伝性感覚性自律神経性ニューロパチー 4型遺伝性感覚性自律神経性ニューロパチー Autosomal Dominant Neuropathy Hereditary Sensory Radicular Congenital Insensitivity to Pain with Anhidrosis Congenital Pain Insensitivity [lsd-project.jp]

Abstract We describe a case of hereditary sensory and autonomic neuropathy (HSAN) type II in a child with a penetrating foot ulcer, acral sensory impairment, and anhidrosis [ncbi.nlm.nih.gov]

We report on a 10-year-old girl with anhidrosis and insensibility to pain, but no severe mental retardation or self-mutilation, diagnosed as hereditary sensory and autonomic [ncbi.nlm.nih.gov]

Peroneal Nerve Paralysis

Abstract Adequate hemostasis is extremely important in extensor reconstruction of the knee and possibly all knee injury. Hemarthrosis postoperatively contributes to postoperative discomfort and may increase the risk of infection. Hematoma formation is also responsible for neurovascular complications. Peroneal[…] [ncbi.nlm.nih.gov]

Acute Pandysautonomia

[…] autonomic neuropathy (ANN): Rare; involvement of both sympathetic and parasympathetic nervous systems; somatic fibres not affected; rare; usually have orthostatic hypotension, anhidrosis [podiapaedia.org]

Department of Neurology,General Hospital of Tianjin,Da Gang Oil Field A case of acute pandysautonomia with clinical manifestations of orthostatic hypo-tension,pupillotonia,anhidrosis [en.cnki.com.cn]

Orthostatic hypotension has not been present in other patients with anhidrosis and Adie's syndrome. [dokumen.tips]

Autonomic Nervous System Disorder

[…] in conjunction with Adie pupil. [12] Chronic idiopathic anhidrosis: Chronic idiopathic anhidrosis is an acquired generalized loss of sweating without other autonomic features [emedicine.medscape.com]

Autonomic failure Orthostatic hypotension Orthostatic intolerance Autonomic and small fiber neuropathy Postural orthostatic tachycardia syndrome (POTS) Sweat disorders, such as anhidrosis [sentara.com]

Anhidrosis may be congenital and occur without any other deficit. [jnnp.bmj.com]

Shy-Drager Syndrome

Postural hypotension correlated with anhidrosis (p less than 0.05), indicating sympathetic vasomotor dysfunction. [ncbi.nlm.nih.gov]

Later symptoms can include impaired speech, difficulties with breathing and swallowing, and inability to sweat (anhidrosis). [medicinenet.com]

Reduction of R-R interval variance after postural changes correlated with constipation (p less than 0.005), postural hypotension (p less than 0.05), and anhidrosis (p less [ncbi.nlm.nih.gov]

Hereditary Sensory Neuropathy

Anhidrosis was documented by the starch-iodine test. [ijpd.in]

Anhidrosis. [ncbi.nlm.nih.gov]

Type 5, congenital insensitivity to pain with partial anhidrosis, also manifests with congenital insensitivity to pain & anhidrosis. [en.wikipedia.org]

Hidrotic Ectodermal Dysplasia

[…] mucous glands which may lead to dried secretions and obstruction atrophic mucosa causing dysphonia hypoplastic-absent mammary glands hypoplastic-absent nipples hypohidrosis anhidrosis [humpath.com]

He suffered from scanty scalp hair and eyebrows since birth with widely spaced conical teeth and anhidrosis. ... more Ectodermal dysplasia is an extremely rare genetic disorder [scinapse.io]

HED is characterized by lack of or diminished sweating (anhidrosis or hypohidrosis), abnormally sparse hair (hypotrichosis), and/or absence (hypodontia) and/or malformation [rarediseases.org]

Horner's Syndrome

[…] rocigonzagua@gmail.com Abstract Horner's syndrome (oculosympathetic paresis) is characterised by the classic triad of ipsilateral palpebral ptosis, pupillary miosis and facial anhidrosis [ncbi.nlm.nih.gov]

Abstract Horner's syndrome is the triad of miosis, ptosis, and anhidrosis, resulting from disruption of the sympathetic pathways. [ncbi.nlm.nih.gov]

This classically produces a triad of signs including miosis, hemifacial anhidrosis and partial ptosis. [prep4medicine.com]

Tonic Pupil

Full Text Introduction In 1958, Alexander Ross described a case with anhidrosis and Adie's syndrome. [journalofoptometry.org]

Introduction In 1958, Alexander Ross described a case with anhidrosis and Adie's syndrome. [ncbi.nlm.nih.gov]

Wietholter Tonic pupil, areflexia, and segmental anhidrosis J Neurol, 239 (1992), pp. 231-234 [9] R.K. Shin, S.L. Galletta, T.Y. Ting, K. Armstrong, S.J. [journalofoptometry.org]

Holmes-Adie Syndrome

Full Text Introduction In 1958, Alexander Ross described a case with anhidrosis and Adie's syndrome. [journalofoptometry.org]

Anhidrosis of the entire face is often associated with a lesion at the level of the carotid artery. [stanfordmedicine25.stanford.edu]

Bachman Bilateral Adie's tonic pupil with anhidrosis and hyperthermia Arch Neurol, 41 (1984), pp. 342-343 [10.] J.G. [archbronconeumol.org]

Harlequin Syndrome

The result is usually unilateral lack of flushing and anhidrosis [ 2 ] ( Figure 1 ). [ncbi.nlm.nih.gov]

This was thought to be due to Ross’s syndrome (Adie’s syndrome with anhidrosis). [doi.org]

Abstract Harlequin syndrome is a rare autonomic disorder characterized by unilateral facial flushing and sweating with contralateral anhidrosis induced by exercise, heat, [ncbi.nlm.nih.gov]

Anisocoria

Other associated signs/symptoms included ptosis (100%), heterochromia (28.1%), anhidrosis (9.4%), straight hair on affected/curly on unaffected side (9.4%), and neck mass [ncbi.nlm.nih.gov]

Abstract Four patients with anhidrosis associated with normal sweat glands at skin biopsy are reported. One patient had a positive family history. [ncbi.nlm.nih.gov]

The following findings are of particular concern: Ptosis Anhidrosis Pupils that respond more to accommodation than light Impaired extraocular movements If the difference in [merckmanuals.com]

Neurological Disorder

There is ample evidence that pinpoints neurological disorders as one of the greatest threats to public health. There are several gaps in understanding the many issues related to neurological disorders, but we already know enough about their nature and treatment to be able to shape effective policy responses to[…] [who.int]

Cold-Induced Sweating Syndrome Type 1

Crisponi/CISS1 syndrome (MIM#272430) is a rare autosomal recessive disease characterized by major feeding difficulties, camptodactyly, and anhidrosis in early childhood; and [portal.findresearcher.sdu.dk]

2016, 170A (5): 1236-41 26804344 Crisponi/CISS1 syndrome (MIM#272430) is a rare autosomal recessive disease characterized by major feeding difficulties, camptodactyly, and anhidrosis [read.qxmd.com]

PDF access through Ovid Abstract Crisponi/CISS1 syndrome (MIM#272430) is a rare autosomal recessive disease characterized by major feeding difficulties, camptodactyly, and anhidrosis [insights.ovid.com]

Autosomal Dominant Hereditary Sensory and Autonomic Neuropathy

CLINICAL REPORT Anesthesia in a patient with congenital insensitivity to pain and anhidrosis Anestesia en paciente con insensibilidad congénita al dolor y anhidrosis Carlos [scielo.br]

Congenital — Congenital Insensitivity to Pain with Anhidrosis — Hereditary Sensory Autonomic Neuropathy, Type 4 — HSAN 4 — Insensitivity to Pain, Congenital, with Anhidrosis [mesh.kib.ki.se]

Anhidrosis was documented by the starch-iodine test. [ijpd.in]

Channelopathy-Associated Congenital Insensitivity to Pain

Congenital insensitivity to pain with anhidrosis. [pediatricneurosciences.com]

Cutaneous features are due to anhidrosis and repeated trauma. [e-ijd.org]

Congenital insensitivity to pain with anhidrosis ( CIPA ) has two characteristic features: the inability to feel pain and temperature, and decreased or absent sweating (anhidrosis [ghr.nlm.nih.gov]

Distal Hereditary Motor Neuropathy Type 5A

There was anhidrosis of palms and soles but hyperhidrosis observed over the back [Figure 3] was notable. [e-ijd.org]

Hereditary motor and sensory neuropathy (HMSN) type 4 Hereditary sensory and autonomic neuropathy type IV (HSAN IV) [8], is a condition associated with insensitivity to pain with anhidrosis [explainmedicine.com]

Other Hereditary Sensory Neuropathies Disorder gene locus inheritance onset clinical Absent pain NGF-b 1p13 Recessive Early childhood to Adult Absence of pain No anhidrosis [slideshare.net]

Cholinergic Urticaria

Idiopathic pure sudomotor failure (IPSF) is a subgroup of acquired idiopathic generalized anhidrosis, which is characterized by early age of onset, acute or sudden onset, [ncbi.nlm.nih.gov]

Kay DM, Maibach HI: Pruritus and acquired anhidrosis. Arch Dermatol 1969;100:291–293. [doi.org]

CU patients are occasionally complicated by anhidrosis and/or hypohidrosis. [ncbi.nlm.nih.gov]

Ectodermal Dysplasia

Ectodermal dysplasias are rare conditions with a triad of hypotrichosis, anodontia and anhidrosis. [ncbi.nlm.nih.gov]

CASE REPORT: We describe a case of Allgrove Syndrome presenting with anhidrosis and peculiar dental features resembling those of Ectodermal Dysplasia (ED). [ncbi.nlm.nih.gov]

We could speculate that hypohidrosis or anhidrosis itself might impair skin barrier function and contribute to atopic diathesis. [ncbi.nlm.nih.gov]

Miliaria

Experimental production in volunteers. ( 6062874 ) SULZBERGER M.B....Wiley H.S. 1967 47 Miliaria and anhidrosis. II. [malacards.org]

Tropical anhidrotic asthenia is a skin condition, a rare form of miliaria, with long-lasting poral occlusion, which produces anhidrosis and heat retention. [en.wikipedia.org]

Anhidrosis develops in the affected sites and may last weeks. If generalized, anhidrosis can lead to hyperpyrexia and heat exhaustion. [emedicine.com]

Lumbar Sympathectomy

The patient had anhidrosis of both feet after surgery with Hyperhidrosis Disease Severity Scale score of 1 at the 1-month follow-up. [ncbi.nlm.nih.gov]

All patients had improvement in foot sweating, with 96.6% achieving total anhidrosis. Five early cases had to be converted to an open surgical method. [ncbi.nlm.nih.gov]

After a 3- to 8-month follow-up period, the anhidrosis persisted in all cases (100%). None of the patients experienced sexual dysfunction. [ncbi.nlm.nih.gov]

Lateral Medullary Syndrome

A classic triad of unilateral symptoms (ptosis, anhidrosis, and miosis) might be seen. [stepwards.com]

Damage to the hypothalamospinal fibers disrupts sympathetic nervous system relay and gives symptoms analogous to Horner syndrome (ptosis, anhidrosis, and miosis). [neuroradiologyonthenet.blogspot.com]

Lesions of descending hypothalamic fibers produce an ipsOateral Horner syndrome (i.e., miosis, ptosis, and anhidrosis). [vertigoexercises.us]

Lytic Bone Lesion

Familial Dysautonomia, Type II Hereditary Sensory And Autonomic Neuropathy IV Neuropathy, Congenital Sensory, With Anhidrosis CIPA HSAN IV HSAN4 256800 Genetic Test Registry [ukgtn.nhs.uk]

Anhidrosis may cause affected skin to become abnormally thickened and callused with an exaggeration of normal skin lines (lichenification). [rarediseases.org]

Congenital Trigeminal Anesthesia

E (2014) Bispectral index monitoring in a patient with combination of congenital insensitivity to pain with anhidrosis (CIPA) and Shwachman–Diamond syndrome. [omicsonline.org]

Syphilis CSB Congenital Short Bowel CSHH Congenital Self-healing Histiocytosis CSHRH Congenital Self-healing Reticulohistiocytosis CSNA Congenital Sensory Neuropathy With Anhidrosis [medicabbreviations.com]

Lesions affecting second-order neurons may cause anhidrosis of the ipsilateral face. [emedicine.medscape.com]

Odonto-Onycho-Dermal Dysplasia

It is characterized by classical triad of hypotrichosis, anhidrosis/hypohidrosis, and hypodontia/anodontia. [contempclindent.org]

Loss-of-function mutation of ITPR2 causes generalized anhidrosis in humans and hypohidrosis in mice. J. Clin Invest. 124(11):4773-80. Schuster, J., Khan, T. [nibge.org]

HED is primarily characterized by partial or complete absence of certain sweat glands (eccrine glands), causing lack of or diminished sweating (anhidrosis or hypohidrosis) [rarediseases.org]