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93 Possible Causes for Anisocytosis, Large Platelets

  • Autosomal Dominant Macrothrombocytopenia

    Platelet anisocytosis, increased percentage of large platelets and absence of leukocyte inclusions were observed in 26/30 (87%) of the examined blood smears.[onlinelibrary.wiley.com] Inspection of blood smears revealed anisocytosis with a small number of giant platelets and electron micrograph images were reminiscent of those from platelets of a patient[bloodjournal.org] An autosomal dominant form of congenital macrothrombocytopenia associated with platelet anisocytosis. It is a disorder of platelet production.[nectarmutation.org]

  • Bernard-Soulier Syndrome

    We report here the case of a BSS patient who presented with persistent thrombocytopenia (31x10 9 /L) and decreased surface expression of GPIb-IX-V on large platelets with anisocytosis[ncbi.nlm.nih.gov] In fact, some authors recommend manual counting of these large platelets, as they are often mistaken as lymphocytes by automatic counters.[symptoma.com] Abstract Bernard-Soulier syndrome is an autosomal recessive coagulopathy characterized by thrombocytopenia, prolonged bleeding time and large platelets.[ncbi.nlm.nih.gov]

  • Gray Platelet Syndrome

    There is variation in platelet size (anisocytosis), even though grey platelet syndrome (GPS) is classified under large platelet syndromes.[patient.info] Gray platelet syndrome (GPS) is a predominantly recessive platelet disorder that is characterized by mild thrombocytopenia with large platelets and a paucity of α-granules[ncbi.nlm.nih.gov] Gray platelet syndrome (GPS) is an autosomal recessive bleeding disorder that is characterized by large platelets that lack α-granules.[ncbi.nlm.nih.gov]

  • Leukoerythroblastic Anemia

    Characteristic changes in peripheral blood include anisocytosis, poikilocytosis, and excessive numbers of RBC and WBC precursors.[msdmanuals.com] platelets This has come up only once, in Question 9.3 from the first paper of 2008 - the same question (and the only question) to discuss leukemoid reaction.[derangedphysiology.com] RBC morphology may show extreme variation (anisocytosis and poikilocytosis) in size and shape. The WBC count may vary.[merckmanuals.com]

  • Microcytic Anemia

    In practice though elliptocytes and anisocytosis are often seen in thalessemia and target cells occasionally in iron deficiency.[en.wikipedia.org] Platelets or thrombocytes These are small parts of large cells called megakaryocytes.[news-medical.net] This is hypochormic microcytic anemia condition Hypochormic as central pallor zone increased in most red cells Microcytic as cells are smaller than normal Anisocytosis (variation[medical-labs.net]

  • Anemia

    […] distribution (the red blood cell distribution width [RDW], a measure of circulating red cell size variability, attempts to quantitate the older descriptor for size heterogeneity:”anisocytosis[cancertherapyadvisor.com] Extremely large spleens cause abdominal pain and a feeling of fullness after eating a small amount of food.[merckmanuals.com] Information about other blood cells (white cells and platelets) is also included in the CBC report.[emedicinehealth.com]

  • Megaloblastic Anemia

    […] pernicious anemia: also atrophic glossitis, atrophic gastritis, neurologic disorders Histology Peripheral blood: normochromic macrocytic anemia, often pancytopenia, significant anisocytosis[atlases.muni.cz] Decreased numbers and immaturity of white blood cells ( leukocytes ) and blood platelets (thrombocytes) may also occur.[diagnose-me.com] The smear shows macro-ovalocytosis, anisocytosis, and poikilocytosis. The RBC distribution width (RDW) is high.[merckmanuals.com]

  • Bleeding Disorder Platelet Type 15

    Laboratory studies show decreased numbers of large platelets and anisocytosis, but the platelets show no in vitro functional abnormalities.[malacards.org] […] data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTN1 Gene - elite association - COSMIC cancer census association via MalaCards Bleeding disorder, platelet-type[genecards.org] The initially adherent platelets release substances into the blood, notably thromboxane and ADP, and this results in the formation of a large platelets aggregate that serves[clinicaladvisor.com]

  • Acquired Idiopathic Sideroblastic Anemia

    […] fatigue, weakness, dyspnea and palpitations on exertion Lab 'Dimorphic' anemia with hypochromic-microcytic and macrocytic features; 40% of erythroblasts are ring sideroblasts, anisocytosis[medical-dictionary.thefreedictionary.com] Sideroblastic Anemia (SA) White cells Normal to decreased Platelets Not remarkable Red cells Commonly microcytic, hypochromic...[5minuteconsult.com] The peripheral blood may present with a dimorphic RBC population in which anisocytosis, poikilocytosis, hypochromia, and basophilic stippling may be observed.[medlabsc.blogspot.com]

  • Normocytic Normochromic Anemia

    […] anemia Lab findings Severe pancytopenia with relative lymphocytosis (lymphocytes live a long time) Normochromic, normocytic RBCs (may be slightly macrocytic) Mild to moderate anisocytosis[slideplayer.com] […] marrow replacement may be suspected on the basis of myeloid metaplasia in the peripheral smear; abnormally shaped erythrocytes and normoblasts, immature granulocytes, and large[cram.com] Characteristic changes in peripheral blood include anisocytosis, poikilocytosis, and excessive numbers of RBC and WBC precursors.[msdmanuals.com]

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