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284 Possible Causes for Anisocytosis, Thrombocytopenia

  • Bleeding Disorder Platelet Type 15

    Thrombocytopenia caused by pregnancy is usually mild and improves soon after childbirth. Immune thrombocytopenia.[mayoclinic.org] Laboratory studies show decreased numbers of large platelets and anisocytosis, but the platelets show no in vitro functional abnormalities.[malacards.org] In addition, the etiology of the thrombocytopenia is often unclear.[anesthesiology.pubs.asahq.org]

  • Microangiopathic Hemolytic Anemia

    In patients with cancer, systemic microvascular metastases and bone marrow involvement can cause microangiopathic hemolytic anemia and thrombocytopenia.[ncbi.nlm.nih.gov] Small schistocytes cause low MCV and high RBC distribution width (the latter reflecting the anisocytosis).[msdmanuals.com] Both the hemolysis and the thrombocytopenia spontaneously improved after the initiation of hemodialysis.[ncbi.nlm.nih.gov]

  • Gray Platelet Syndrome

    GPS is an α-granule defect associated with the development of myelofibrosis and mild to moderate thrombocytopenia.[ncbi.nlm.nih.gov] There is variation in platelet size (anisocytosis), even though grey platelet syndrome (GPS) is classified under large platelet syndromes.[patient.info] We report a case of gray platelet syndrome (GPS) associated with immune thrombocytopenia (ITP) at presentation.[ncbi.nlm.nih.gov]

  • Pancytopenia

    […] mm(3), and severe thrombocytopenia as thrombocyte counts below 20,000/mm(3).[ncbi.nlm.nih.gov] His peripheral blood smear showed marked anisocytosis and poikilocytosis with elevated atypical lymphocytes.[ncbi.nlm.nih.gov] Peripheral blood findings Anisocytosis of varying severity was the commonest morphologic type (58%) followed by normocytic normochromic (34%) and dimorphic picture (8%) in[mjdrdypu.org]

  • Myelodysplasia

    Therapy with granulocyte-colony stimulating factor (G-CSF) and granulocyte-monocyte-colony stimulating factor (GM-CSF) caused splenomegaly and severe thrombocytopenia, which[ncbi.nlm.nih.gov] Anemia is the most common feature, associated usually with macrocytosis and anisocytosis.[merckmanuals.com] Thrombocytopenia typically manifests as petechiae or ecchymoses; epistaxis and gum bleeding suggest severe thrombocytopenia.[emedicine.medscape.com]

  • Chronic Myeloid Leukemia

    […] without thrombocytopenia (p   0.01).[ncbi.nlm.nih.gov] The red cells showed mild anisocytosis and poikilocytosis.[path.upmc.edu] Immune thrombocytopenia (ITP) was also diagnosed in this patient following the detection of antiplatelet autoantibodies.[ncbi.nlm.nih.gov]

  • Leukoerythroblastic Anemia

    Acute Erythroblastic Leukemia Anemia, X-Linked, without Thrombocytopenia aplastic anemia Aplastic Anemia, Idiopathic Bone Marrow Failure Syndromes chronic myeloid leukemia[rgd.mcw.edu] Characteristic changes in peripheral blood include anisocytosis, poikilocytosis, and excessive numbers of RBC and WBC precursors.[merckmanuals.com] […] who presented seven years following apparently successful surgery and adjuvant chemo-radio-therapy, with blood film findings of microangiopathic hemolytic anemia (MAHA), thrombocytopenia[ncbi.nlm.nih.gov]

  • Fetal Erythroblastosis

    Schistocytes, as a sign of disseminated intravascular coagulation and burr cells, are present, as well as neutropenia and thrombocytopenia.[symptoma.com] "Neutropenia and thrombocytopenia in infants with Rh hemolytic disease". The Journal of Pediatrics . 114 (4 Pt 1): 625–31.[en.wikipedia.org] Fetal/neonatal alloimmune thrombocytopenia: pathogenesis, diagnostics and prevention. Arch Immunol Ther Exp (Warsz) . 2015 Nov 12. [Medline] . Koenig JM.[emedicine.medscape.com]

  • Thrombotic Thrombocytopenic Purpura

    Unfortunately, there is no clear guidance for when thrombocytopenia is refractory for a prolonged period of time.[ncbi.nlm.nih.gov] Examination of the peripheral blood smear (Fig. 1 ) showed marked anisocytosis, severe decrease in platelets and the presence of abundant schistocytes.[jitc.biomedcentral.com] Careful analysis revealed the development of heparin-induced thrombocytopenia (HIT) that precluded platelet count (PLT) normalization.[ncbi.nlm.nih.gov]

  • Glucose-6-Phosphate Dehydrogenase Deficiency

    The evolution was marked by a respiratory distress syndrome, a severe hemolytic anemia, associated with thrombocytopenia and kidney failure.[ncbi.nlm.nih.gov] Anisocytosis: unequal red cells sizes as indicated by increased red cell distribution width (RDW) Hemolysis leads to increased cell fragments.[pathophys.org] Paroxysmal nocturnal hemoglobinuria (PNH) Hemolytic-uremic syndrome (HUS)/thrombotic thrombocytopenic purpura (TTP) - look for thrombocytopenia - If enterohemorrhagic Escherichia[cancertherapyadvisor.com]

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