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284 Possible Causes for Anisocytosis, Thrombocytopenia

  • Bleeding Disorder Platelet Type 15

    Thrombocytopenia caused by pregnancy is usually mild and improves soon after childbirth. Immune thrombocytopenia.[] Laboratory studies show decreased numbers of large platelets and anisocytosis, but the platelets show no in vitro functional abnormalities.[] In addition, the etiology of the thrombocytopenia is often unclear.[]

  • Microangiopathic Hemolytic Anemia

    In patients with cancer, systemic microvascular metastases and bone marrow involvement can cause microangiopathic hemolytic anemia and thrombocytopenia.[] Small schistocytes cause low MCV and high RBC distribution width (the latter reflecting the anisocytosis).[] Both the hemolysis and the thrombocytopenia spontaneously improved after the initiation of hemodialysis.[]

  • Gray Platelet Syndrome

    GPS is an α-granule defect associated with the development of myelofibrosis and mild to moderate thrombocytopenia.[] There is variation in platelet size (anisocytosis), even though grey platelet syndrome (GPS) is classified under large platelet syndromes.[] We report a case of gray platelet syndrome (GPS) associated with immune thrombocytopenia (ITP) at presentation.[]

  • Pancytopenia

    […] mm(3), and severe thrombocytopenia as thrombocyte counts below 20,000/mm(3).[] His peripheral blood smear showed marked anisocytosis and poikilocytosis with elevated atypical lymphocytes.[] Peripheral blood findings Anisocytosis of varying severity was the commonest morphologic type (58%) followed by normocytic normochromic (34%) and dimorphic picture (8%) in[]

  • Myelodysplasia

    Therapy with granulocyte-colony stimulating factor (G-CSF) and granulocyte-monocyte-colony stimulating factor (GM-CSF) caused splenomegaly and severe thrombocytopenia, which[] Anemia is the most common feature, associated usually with macrocytosis and anisocytosis.[] Thrombocytopenia typically manifests as petechiae or ecchymoses; epistaxis and gum bleeding suggest severe thrombocytopenia.[]

  • Chronic Myeloid Leukemia

    […] without thrombocytopenia (p   0.01).[] The red cells showed mild anisocytosis and poikilocytosis.[] Immune thrombocytopenia (ITP) was also diagnosed in this patient following the detection of antiplatelet autoantibodies.[]

  • Leukoerythroblastic Anemia

    Acute Erythroblastic Leukemia Anemia, X-Linked, without Thrombocytopenia aplastic anemia Aplastic Anemia, Idiopathic Bone Marrow Failure Syndromes chronic myeloid leukemia[] Characteristic changes in peripheral blood include anisocytosis, poikilocytosis, and excessive numbers of RBC and WBC precursors.[] […] who presented seven years following apparently successful surgery and adjuvant chemo-radio-therapy, with blood film findings of microangiopathic hemolytic anemia (MAHA), thrombocytopenia[]

  • Fetal Erythroblastosis

    Schistocytes, as a sign of disseminated intravascular coagulation and burr cells, are present, as well as neutropenia and thrombocytopenia.[] "Neutropenia and thrombocytopenia in infants with Rh hemolytic disease". The Journal of Pediatrics . 114 (4 Pt 1): 625–31.[] Fetal/neonatal alloimmune thrombocytopenia: pathogenesis, diagnostics and prevention. Arch Immunol Ther Exp (Warsz) . 2015 Nov 12. [Medline] . Koenig JM.[]

  • Thrombotic Thrombocytopenic Purpura

    Unfortunately, there is no clear guidance for when thrombocytopenia is refractory for a prolonged period of time.[] Examination of the peripheral blood smear (Fig. 1 ) showed marked anisocytosis, severe decrease in platelets and the presence of abundant schistocytes.[] Careful analysis revealed the development of heparin-induced thrombocytopenia (HIT) that precluded platelet count (PLT) normalization.[]

  • Glucose-6-Phosphate Dehydrogenase Deficiency

    The evolution was marked by a respiratory distress syndrome, a severe hemolytic anemia, associated with thrombocytopenia and kidney failure.[] Anisocytosis: unequal red cells sizes as indicated by increased red cell distribution width (RDW) Hemolysis leads to increased cell fragments.[] Paroxysmal nocturnal hemoglobinuria (PNH) Hemolytic-uremic syndrome (HUS)/thrombotic thrombocytopenic purpura (TTP) - look for thrombocytopenia - If enterohemorrhagic Escherichia[]

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