Anisopoikilocytosis: Causes & Reasons

Possible Causes for Anisopoikilocytosis

Blood analysis shows reduced Hb levels (< 7 g/dl), mean corpuscular volume (MCV) > 50 < 70 fl, and mean corpuscular Hb (MCH) > 12 < 20 pg, anisopoikilocytosis and presence [orpha.net]

Blood sample Microcytic hypochromic anemia Signs of hemolysis (↓ haptoglobin, ↑ LDH, ↑ indirect bilirubin, ↑ reticulocytes) Blood smear: target cells;, teardrop cells;, anisopoikilocytosis [amboss.com]

Myelodysplasia

A blood smear examination revealed significantly large numbers of schistocytes and marked anisopoikilocytosis. [jstage.jst.go.jp]

Red cell morphology in the peripheral blood may be normal or macrocytic with anisopoikilocytosis. [cancertherapyadvisor.com]

Schistocytosis as well as anisopoikilocytosis in the blood may reflect defective erythrocyte development in the bone marrow. [jstage.jst.go.jp]

Iron Deficiency Anemia

The peripheral smear generally reveals hypochromic red cells with significant anisopoikilocytosis, which is reflected in a high red cell distribution width (RDW). [msdmanuals.com]

Mucopolysaccharidosis Type 2

Blood film: Anisopoikilocytosis, microcytosis, hypochromia with pencil cells (showing iron deficiency). SEUC; urea: 20 mg/dl (2.5–6.4 mg/dl). [amhsr.org]

Hemoglobin Bart's Disease

Peripheral smear shows target cells, teardrop RBCs, polychromasia, moderate anisopoikilocytosis, and basophilic stippling. [clinicaladvisor.com]

Mucopolysaccharidosis

Definition: Systemic lysosomal storage disease caused by a deficiency of alpha-L-iduronidase ( IDURONIDASE ) and characterized by progressive physical deterioration with urinary excretion of DERMATAN SULFATE and HEPARAN SULFATE. There are three recognized phenotypes representing a spectrum of clinical severity[…] [hon.ch]

Hodgkin Lymphoma

The endobronchial localization of Hodgkin's disease is a rare entity which is often confused with endobronchial tuberculosis in our setting. We report the case of a 16 years old female who presented with 6 months history of dry cough, hemoptysis, dyspnea, dysphagia and dysphonia. The chest radiography showed a[…] [ncbi.nlm.nih.gov]

Congenital Hemolytic Anemia

Hereditary pyropoikilocytosis is an inherited red cell membrane disorder with characteristic morphology: striking anisopoikilocytosis with red cell fragmentation and microspherocytes [scholars.northwestern.edu]

Description Hereditary pyropoikilocytosis (HPP) is a recessively inherited form of hemolytic anemia characterized by peripheral blood morphology presenting with striking anisopoikilocytosis [genome.jp]

Presence of marked anisopoikilocytosis, hypochromia and target cells should prompt the clinician to investigate for thalassemia syndromes. [bioline.org.br]

Hemoglobin E Disease

The peripheral blood picture showed severe anisopoikilocytosis of the red blood cells (RBCs) with the presence of a fair number of microcytes, target cells, tear drop cells [jdrntruhs.org]

The general blood picture showed mild anisopoikilocytosis of red blood cells (RBCs) with the presence of microcytes, target cells and hypochromia. [ijpmonline.org]

Aggarwal et al also [6] found microcytic hypochromic picture with anisopoikilocytosis in HbE trait. [medresearch.in]

Hemoglobin Lepore-Beta-Thalassemia Syndrome

His complete blood count revealed mild anemia and peripheral blood smear examination revealed microcytic hypochromic red blood cells, with moderate anisopoikilocytosis and [ejpmr.com]

We had 6 such cases, presenting with severe anemia, marked anisopoikilocytosis, microcytosis, target cells and basophilic stippling. [ijpmonline.org]

Cases diagnosed with beta thalassemia intermedia had variable degree of anemia with anisopoikilocytosis and microcytic hypochromic (MCHC) blood picture. [ijpmonline.org]

Hypocupremia

Serum ceruloplasmin 2.34 mg/dl, serum copper 16 mg/dl and serum Zinc 155 μg/dl and a normocytic normochromic anemia with anisopoikilocytosis. [bioline.org.br]

Serum ceruloplasmin 2.34 mg/dl, serum copper 16 μg/dl and serum Zinc 155 μg/dl and a normocytic normochromic anemia with anisopoikilocytosis. [neurologyindia.com]

Acute Panmyelosis with Myelofibrosis

Acute myelofibrosis differs by its aggressiveness, by the fact that it is more common in children, and by lack of organomegaly or anisopoikilocytosis. [journals.lww.com]

Red blood cells were normocytic normochromic with minimal anisopoikilocytosis. Eight nucleated red blood cells were seen per hundred white blood cells. [ncbi.nlm.nih.gov]

The characteristic peripheral blood changes of anisopoikilocytosis, leukoerythroblastosis, and the presence of significant splenomegaly help in diagnosis. [ajmhs.org]

Dimorphic Anemia

[…] of the RBCs are the characteristic morphologic abnormalities Terminology Iron deficiency anemia (IDA) Microcytic, hypochromic anemia with anisopoikilocytosis Anemia of chronic [pathologyoutlines.com]

[…] colonization and chronic inflammation Low ferritin levels; ferritin is an indicator of iron stores and is the most sensitive and specific biomarker Hypochromia, microcytosis and anisopoikilocytosis [pathologyoutlines.com]

[…] images Images hosted on other servers: Koilonychia Atrophic glossitis Microscopic (histologic) description Peripheral blood smear: Microcytic and hypochromic RBCs with marked anisopoikilocytosis [pathologyoutlines.com]

Woronets Trait

ORPHA:288 Imerslund-Gräsbeck Syndrome Megaloblastic anemia, Neutropenia, Anisopoikilocytosis, Macrocytic anemia, Thrombocytopenia, Oval... [mousephenotype.org]

ORPHA:231226 Lathosterolosis Hepatosplenomegaly, Anisopoikilocytosis, Acanthocytosis, Schistocytosis, Increased mean platelet ... [mousephenotype.org]

ORPHA:766 Dehydrated Hereditary Stomatocytosis 2 Increased mean corpuscular volume, Splenomegaly, Anisopoikilocytosis, Acanthocytosis, Increased m... [mousephenotype.org]

Thiamine-Responsive Megaloblastic Anemia - Diabetes Mellitus - Sensorineural Deafness

The peripheral smear showed anisopoikilocytosis with macrocytosis and microcytosis. [latunisiemedicale.com]

Thiamine-Responsive Megaloblastic Anemia

The peripheral smear showed anisopoikilocytosis with macrocytosis and microcytosis. [latunisiemedicale.com]

Hereditary Pyropoikilocytosis

Hereditary pyropoikilocytosis (HPP) is a severe, congenital hemolytic anemia occurring almost exclusively in black persons and characterized by extreme red blood cell anisopoikilocytosis [ncbi.nlm.nih.gov]

AB - Hereditary pyropoikilocytosis is an inherited red cell membrane disorder with characteristic morphology: striking anisopoikilocytosis with red cell fragmentation and [scholars.northwestern.edu]

Imerslund-Gräsbeck Syndrome

Cabot rings and marked anisopoikilocytosis in Imerslund-Gräsbeck syndrome. Blood. 2018;131(1):153. doi:10.1182/blood-2017-10-809178 DOWNLOADS Since June 15, 2019 COinS [scholarlyexchange.childrensmercy.org]

He had leucopenia, anisopoikilocytosis, megaloblastic erythropoiesis, megakaryocytes with low serum B12 level. His younger sibling was similarly affected. [nlm.medscape.idmu.unboundmedicine.unboundmedicine.com]

Complete blood count and peripheral blood smear examination revealed a normocytic normochromic to microcytic hypochromic anaemia with mild anisopoikilocytosis. [oatext.com]

Stomatocytosis Type 2

Few target cells, anisopoikilocytosis and erythrocytes having a central mouthlike or "stoma" appearance [Figure 1]. [mjdrdypu.org]

A peripheral blood smear showed anisopoikilocytosis with rare stomatocytes and no spherocytes (Figure 1B). [haematologica.org]

Both patients displayed moderate hemolytic anemia, reticulocytosis and abnormal RBC morphology with marked anisopoikilocytosis and stomatocytosis. [nature.com]

Macrocytic Hyperchromic Anemia

The marked anisopoikilocytosis induced by the intramedullary hemolysis secondary to vitamin B12 deficiency, including the presence of teardrop cells and schistocytes, masks [link.springer.com]

Congenital Dyserythropoietic Anemia Type 1B

Anisopoikilocytosis with tear-drop forms, polychromasia, basophilic stippling in peripheral blood smear, erythroid hyperplasia with megaloblastoid changes, binucleated cells [unboundmedicine.com]

Peripheral blood smear examination showed prominent anisopoikilocytosis, basophilic stippling, and the presence of erythroblasts. [cureus.com]

[…] that has been reported mainlyfrom the Central and Western European countries andNorth Africa with very few cases reported from IndianSubcontinent [1].Fig. 1 Blood smear a Anisopoikilocytosis [docslide.com.br]

Hemoglobin E-Thalassemia

The peripheral blood picture showed severe anisopoikilocytosis of the red blood cells (RBCs) with the presence of a fair number of microcytes, target cells, tear drop cells [jdrntruhs.org]

The general blood picture showed mild anisopoikilocytosis of red blood cells (RBCs) with the presence of microcytes, target cells and hypochromia. [ijpmonline.org]

Peripheral smear from a patient with beta-zero thalassemia major showing more marked microcytosis (M) and anisopoikilocytosis (P) than in thalassemia minor. [emedicine.medscape.com]

Refractory Megaloblastic Anemia

• PB smear shows abnormality in all three lines• Red cell anisopoikilocytosis• Large, giant or hypogranular platelets• Abnormal cytoplasmic granularity & nuclear segmentation [slideshare.net]

Peripheral smear revealed anisopoikilocytosis, macro-ovalocytes with decreased TLC and reduced platelets. The liver and kidney function tests were normal. [tropej.oxfordjournals.org]

SECONDARY/THERAPY RELATED MDS• Occur post-chemotherapy or post-radiation therapy, benzene toxins• Mean age of presentation is 10 yrs earlier than primary• PS – Anisopoikilocytosis [slideshare.net]

Refractory Anemia with Excess Blasts

There can also be abnormal platelets (large, giant or hypogranular) and red cell anisopoikilocytosis. Blasts are commonly present. [imagebank.hematology.org]

[…] prognostic group Median survival is ˜ 16-40 months RAEB-2 High-risk group Median survival is ˜ 9-20 months MICROSCOPIC PATHOLOGY Cytologic Features Peripheral blood Anemia with anisopoikilocytosis [basicmedicalkey.com]

Red cell morphology in the peripheral blood may be normal or macrocytic with anisopoikilocytosis. [clinicaladvisor.com]

Refractory Anemia with Excess Blasts in Transformation

There can also be abnormal platelets (large, giant or hypogranular) and red cell anisopoikilocytosis. Blasts are commonly present. [imagebank.hematology.org]

The peripheral blood smear of a patient with MDS will often show anisopoikilocytosis and macrocytosis of the red cells. [pedimds.org]

 Anisopoikilocytosis, large/giant/hypogranular platelets, abnormal cytoplasmic granularity and nuclear segmentation of neutrophils, Auer rods absent.  44. [slideshare.net]

Refractory Anemia

There can also be abnormal platelets (large, giant or hypogranular) and red cell anisopoikilocytosis. Blasts are commonly present. [imagebank.hematology.org]

AML transformation = 10% at 2 yrs This myelodysplastic syndrome presents with a Bi- or Tri-lineage dysplasia in which there is anemia with anisopoikilocytosis, Abnormal PMN [quizlet.com]

Rothmann-Makai Syndrome

A peripheral blood smear revealed anisopoikilocytosis and numerous Howell–Jolly bodies, indicating functional hyposplenism. [tropicalmedandhygienejrnl.net]

Beta Thalassemia

A peripheral blood smear revealed anisopoikilocytosis with hypochromic microcytic red cells, target cells, and basophilic stippling ( Fig. 1A ). [ncbi.nlm.nih.gov]

Blood analysis shows reduced Hb levels (< 7 g/dl), mean corpuscular volume (MCV) > 50 < 70 fl, and mean corpuscular Hb (MCH) > 12 < 20 pg, anisopoikilocytosis and presence [orpha.net]

Peripheral smear from a patient with beta-zero thalassemia major showing more marked microcytosis (M) and anisopoikilocytosis (P) than in thalassemia minor. [emedicine.medscape.com]

Hypochromic Microcytic Anemia with Iron Overload Type 2

Peripheral blood smear examination showed marked anisopoikilocytosis with moderate microcytic hypochromic cells and dimorphic blood picture [Figure 1] a, moderate polychromasia [jahjournal.org]

The peripheral blood shows macrocytic anemia with marked anisopoikilocytosis, polychromasia, and basophilic stippling. [basicmedicalkey.com]

Dihydropyrimidinuria

[…] experimental gene therapy Increased adenosine deaminase (102730) Adenosine deaminase ADA Biochemical profile: Mild hyperuricemia Clinical features: Hemolytic anemia with anisopoikilocytosis [merckmanuals.com]