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79 Possible Causes for Anisopoikilocytosis, Macrocytic Anemia

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  • Myelodysplasia

    Medical Importance The myelodysplastic syndromes are clonal hematopoietic disorders that commonly cause macrocytic anemia in older patients.[hematology.org] Red cell morphology in the peripheral blood may be normal or macrocytic with anisopoikilocytosis.[clinicaladvisor.com] Initial stages of MDS may be characterized by macrocytic anemia with mild thrombocytopenia or neutropenia.[symptoma.com]

  • Congenital Dyserythropoietic Anemia

    This report describes a case of congenital dyserythropoietic anemia (CDA) type I diagnosed in a 22-year-old woman with a two year history of macrocytic anemia.[ncbi.nlm.nih.gov] Anisopoikilocytosis with tear-drop forms, polychromasia, basophilic stippling in peripheral blood smear, erythroid hyperplasia with megaloblastoid changes, binucleated cells[ncbi.nlm.nih.gov] […] and hallux varus deformity of the great toe of the right foot was diagnosed to have congenital dyserythropoietic anemia on the basis of the hematological (macrocytosis, anisopoikilocytosis[ncbi.nlm.nih.gov]

  • Refractory Megaloblastic Anemia

    Examples include causesof splenomegaly, indications for splenectomy, differential diagnosis of normocytic anemia,macrocytic anemia, hypochromic anemia, thrombocytopenia, bone[books.google.de] Peripheral smear revealed anisopoikilocytosis, macro-ovalocytes with decreased TLC and reduced platelets. The liver and kidney function tests were normal.[tropej.oxfordjournals.org] TOC HEME Approach to Macrocytic /Megaloblastic Anemia By means of morphologic and biochemical criteria, macrocytic anemias can be divided into two groups: The megaloblastic[enotes.tripod.com]

  • Acute Erythroblastic Leukemia

    : hypogranulation, hyposegmentation Megakaryocytes: small, non-lobulated cells Older patients Asymptomatic, or BM failure Macrocytic anemia Low-grade: support, follow.[quizlet.com] Peripheral blood findings in AEL are generally non-specific and include anisopoikilocytosis, as in this case (Figure 1), basophilic stippling, schistocytes, and anisochromia[path.upmc.edu] An excellent example was case 352 Image 1D , a 20-year-old man who had jaundice and severe macrocytic anemia.[academic.oup.com]

  • Megaloblastic Anemia

    macrocytic anemia.[livehealthy.chron.com] [ macrocytosis is the earliest sign in Vit B12 deficiency and can be detected even before the onset of anaemia ] - In severe anaemia in addition to macrocytosis, marked anisopoikilocytosis[slideshare.net] TOC HEME Approach to Macrocytic /Megaloblastic Anemia By means of morphologic and biochemical criteria, macrocytic anemias can be divided into two groups: The megaloblastic[enotes.tripod.com]

  • Congenital Hemolytic Anemia

    The Type I cases showed the following features: normocytic or slightly macrocytic anemia with mild hypochromia and some stippling; a decreased or normal osmotic fragility[bloodjournal.org] Hereditary pyropoikilocytosis is an inherited red cell membrane disorder with characteristic morphology: striking anisopoikilocytosis with red cell fragmentation and microspherocytes[scholars.northwestern.edu] Diamond–Blackfan anemia Acquired: PRCA Sideroblastic anemia Myelophthisic Blood tests MCV Normocytic Microcytic Macrocytic MCHC Normochromic Hypochromic Other Methemoglobinemia[en.wikipedia.org]

  • Refractory Anemia with Excess Blasts

    A 19-month-old boy was referred to our institution because of chronic macrocytic anemia and severe thrombocytopenia. At age 17 months, he had developed petechiae.[ncbi.nlm.nih.gov] There can also be abnormal platelets (large, giant or hypogranular) and red cell anisopoikilocytosis. Blasts are commonly present.[imagebank.hematology.org] […] prognostic group Median survival is 16-40 months RAEB-2 High-risk group Median survival is 9-20 months MICROSCOPIC PATHOLOGY Cytologic Features Peripheral blood Anemia with anisopoikilocytosis[basicmedicalkey.com]

  • Extramedullary Hematopoiesis

    Common causes of EMH include spherocytic anemia, erythroblastosis of newborn, thalassemia, pernicious anemia in period of relapse, macrocytic anemia of hepatic origin, carcinoma[lungindia.com] […] granulocyte and megakaryocytic series along with fibrillary and adipose elements Click here to view Further confirmation done by the peripheral blood film, which showed mild anisopoikilocytosis[lungindia.com]

  • Myeloid Metaplasia

    Examples include causesof splenomegaly, indications for splenectomy, differential diagnosis of normocytic anemia,macrocytic anemia, hypochromic anemia, thrombocytopenia, bone[books.google.com] Images hosted on PathOut server: Peripheral blood: Moderate anisopoikilocytosis with dacrocytes and elliptocytes Postsplenectomy patient has marked increase in normoblasts[pathologyoutlines.com] , Fanconi anemia , Sideroblastic anemia Blood tests Normocytic - Microcytic - Macrocytic - Normochromic - Hypochromic Other Methemoglobinemia Coagulation / platelets / coagulopathy[wikidoc.org]

  • Primary Myelofibrosis

    Images hosted on PathOut server: Peripheral blood: Moderate anisopoikilocytosis with dacrocytes and elliptocytes Postsplenectomy patient has marked increase in normoblasts[pathologyoutlines.com] The anisopoikilocytosis, nucleated red cells, and myeloid immaturity in the blood film characteristic of myelofibrosis are not present in patients with thrombocythemia.[patient-help.com] The absence of a high frequency of teardrop-shaped red cells, nucleated red cells, and striking anisopoikilocytosis in the blood film mitigates against primary myelofibrosis[patient-help.com]

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