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1,055 Possible Causes for Ankle Edema, Antithrombin III Increased, Discoloration of the Lower Extremity

  • Deep Vein Thrombosis

    A 38-year-old Sri Lankan man presented with acute pancreatitis and later he developed progressive abdominal distention with bilateral ankle edema.[] Antithrombin III (AT) is the most important endogenous anticoagulant, and genetic variability in SERPINC1, gene encoding AT, is low.[] The patient's left lower extremity was discolored, tender, and swollen, although it had not progressed to venous gangrene or dermal necrosis.[]

  • Varicose Veins

    Learn more: Swollen feet, ankles, and hands (edema) during pregnancy Itching during pregnancy Help for common pregnancy skin problems[] On Mammen's “hit list” nearly 20 years ago were included (among inherited abnormalities) decreased protein C, protein S, antithrombin III, plasminogen, and tissue plasminogen[] Severe venous reflux can result in skin discoloration, severe swelling, and lower extremity wounds that do not heal well.[]

  • Henoch-Schönlein Purpura

    A 20-year-old man was admitted to the hospital with a one-day history of fever and acute, painful symmetric polyarthritis that involved the wrists, elbows, and ankles.[] Joint pain – Pain or soreness comes in the joints, usually the knees and ankles. It tends to move around from one area to another.[] Subcutaneous edema (20-50%) Scrotal edema (2-35%) Bloody stools Because HSP can affect all organ systems, a full physical examination is indicated.[]

    Missing: Antithrombin III Increased
  • Cor Pulmonale

    Physical findings may include: Jugular venous distension: Prominent jugular V wave, indicating the presence of tricuspid regurgitation Peripheral (ankle) edema: The best sign[] Hypercoagulability is evaluated by serum levels of proteins S and C, Antithrombin III, Anticardiolipin antibodies, and Homocysteine (Klinger, 2005).[] The physical examination findings evaluated in the study include ankle edema and prominent jugular vein.[]

    Missing: Discoloration of the Lower Extremity
  • Nephrotic Syndrome

    Nephrotic syndrome causes swelling (edema), particularly in your feet and ankles, and increases the risk of other health problems.[] III Increased hepatic synthesis of clotting factors Platelet abnormalities Hyperviscosity caused by hypovolemia Protein undernutrition in children (sometimes with brittle[] ) particularly in the abdomen, but also the ankles, feet and/or face, weight gain, and less but foamy urine output.[]

    Missing: Discoloration of the Lower Extremity
  • Stasis Dermatitis

    Earlier signs, such as prominent superficial veins and pitting ankle edema, are well known.[] Symptoms Swelling around the ankles that usually goes away while you’re asleep but comes back the next day Discoloration of the skin or hyperpigmentation on the lower extremities[] edema and progressing to tan pigmentation, patchy erythema, petechiae, and induration.[]

    Missing: Antithrombin III Increased
  • Glomerulonephritis

    Glomerulonephritis damages the glomeruli, causing symptoms such as blood in the urine, foamy urine, and swelling (edema) around the face, eyes, ankles, legs, and abdomen.[] Antithrombin-III loss results in an increased susceptibility to thrombosis with, e.g., pulmonary embolism, renal vein thrombosis, or cerebral vein thrombosis.[] Early signs and symptoms of the chronic form may include: Blood or protein in the urine (hematuria, proteinuria) High blood pressure Swelling of your ankles or face (edema[]

    Missing: Discoloration of the Lower Extremity
  • Thromboembolism

    III, protein C or protein S High concentrations of factor VIII or XI Increased lipoprotein (a) - test in those 50y with recurrent or a strong FHx MANAGEMENT many different[] Signs/Symptoms Nonspecific; pain, tenderness, swelling, discoloration (paleness or redness) in lower extremities.[] Leiden mutation Prothombin gene mutation (G20210A) hyperhomocysteinemia Antiphospholipid antibody syndrome (lupus anti-coagulant & anti-cardiolipin antibodies) Deficiency of antithrombin[]

    Missing: Ankle Edema
  • Venous Disorder of Lower Extremity

    Diameters of varicose veins can range from 3 mm to 8 mm.2 Edema & leg or ankle swelling with and without skin changes Edema and swollen ankles are the next progressive states[] […] and a decrease in total and free protein S, antithrombin III, and fibrinolytic activity.[] B) an open wound on the lower extremities. C) brownish or grayish discoloration of the skin. D) hard, waxy, hyperpigmented tissue with swelling of the surrounding areas.[]

  • Bronchitis

    Decreased levels of oxygen in the blood can also lead to peripheral edema, or swelling in the legs and ankles.[]

    Missing: Antithrombin III Increased Discoloration of the Lower Extremity