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1,055 Possible Causes for Ankle Edema, Antithrombin III Increased, Discoloration of the Lower Extremity

  • Deep Vein Thrombosis

    A 38-year-old Sri Lankan man presented with acute pancreatitis and later he developed progressive abdominal distention with bilateral ankle edema.[ncbi.nlm.nih.gov] Antithrombin III (AT) is the most important endogenous anticoagulant, and genetic variability in SERPINC1, gene encoding AT, is low.[ncbi.nlm.nih.gov] The patient's left lower extremity was discolored, tender, and swollen, although it had not progressed to venous gangrene or dermal necrosis.[ncbi.nlm.nih.gov]

  • Varicose Veins

    Learn more: Swollen feet, ankles, and hands (edema) during pregnancy Itching during pregnancy Help for common pregnancy skin problems[babycenter.com] On Mammen's “hit list” nearly 20 years ago were included (among inherited abnormalities) decreased protein C, protein S, antithrombin III, plasminogen, and tissue plasminogen[dx.doi.org] Severe venous reflux can result in skin discoloration, severe swelling, and lower extremity wounds that do not heal well.[health.ucsd.edu]

  • Henoch-Schönlein Purpura

    A 20-year-old man was admitted to the hospital with a one-day history of fever and acute, painful symmetric polyarthritis that involved the wrists, elbows, and ankles.[nejm.org] Joint pain – Pain or soreness comes in the joints, usually the knees and ankles. It tends to move around from one area to another.[nationwidechildrens.org] Subcutaneous edema (20-50%) Scrotal edema (2-35%) Bloody stools Because HSP can affect all organ systems, a full physical examination is indicated.[emedicine.com]

    Missing: Antithrombin III Increased
  • Cor Pulmonale

    Physical findings may include: Jugular venous distension: Prominent jugular V wave, indicating the presence of tricuspid regurgitation Peripheral (ankle) edema: The best sign[ncbi.nlm.nih.gov] Hypercoagulability is evaluated by serum levels of proteins S and C, Antithrombin III, Anticardiolipin antibodies, and Homocysteine (Klinger et.al, 2005).[asrn.org] The physical examination findings evaluated in the study include ankle edema and prominent jugular vein.[chronic-obstructive-pulmonary-disease.imedpub.com]

    Missing: Discoloration of the Lower Extremity
  • Nephrotic Syndrome

    Nephrotic syndrome causes swelling (edema), particularly in your feet and ankles, and increases the risk of other health problems.[mayoclinic.com] III Increased hepatic synthesis of clotting factors Platelet abnormalities Hyperviscosity caused by hypovolemia Protein undernutrition in children (sometimes with brittle[merckmanuals.com] ) particularly in the abdomen, but also the ankles, feet and/or face, weight gain, and less but foamy urine output.[nicklauschildrens.org]

    Missing: Discoloration of the Lower Extremity
  • Stasis Dermatitis

    Earlier signs, such as prominent superficial veins and pitting ankle edema, are well known.[ncbi.nlm.nih.gov] Symptoms Swelling around the ankles that usually goes away while you’re asleep but comes back the next day Discoloration of the skin or hyperpigmentation on the lower extremities[verywellhealth.com] edema and progressing to tan pigmentation, patchy erythema, petechiae, and induration.[medical-dictionary.thefreedictionary.com]

    Missing: Antithrombin III Increased
  • Glomerulonephritis

    Glomerulonephritis damages the glomeruli, causing symptoms such as blood in the urine, foamy urine, and swelling (edema) around the face, eyes, ankles, legs, and abdomen.[kidshealth.org] Antithrombin-III loss results in an increased susceptibility to thrombosis with, e.g., pulmonary embolism, renal vein thrombosis, or cerebral vein thrombosis.[lecturio.com] Early signs and symptoms of the chronic form may include: Blood or protein in the urine (hematuria, proteinuria) High blood pressure Swelling of your ankles or face (edema[kidney.org]

    Missing: Discoloration of the Lower Extremity
  • Thromboembolism

    III, protein C or protein S High concentrations of factor VIII or XI Increased lipoprotein (a) - test in those 50y with recurrent or a strong FHx MANAGEMENT many different[lifeinthefastlane.com] Signs/Symptoms Nonspecific; pain, tenderness, swelling, discoloration (paleness or redness) in lower extremities.[strokecenter.org] Leiden mutation Prothombin gene mutation (G20210A) hyperhomocysteinemia Antiphospholipid antibody syndrome (lupus anti-coagulant & anti-cardiolipin antibodies) Deficiency of antithrombin[lifeinthefastlane.com]

    Missing: Ankle Edema
  • Venous Disorder of Lower Extremity

    Diameters of varicose veins can range from 3 mm to 8 mm.2 Edema & leg or ankle swelling with and without skin changes Edema and swollen ankles are the next progressive states[thepremierveincenter.com] […] and a decrease in total and free protein S, antithrombin III, and fibrinolytic activity.[venousdisease.com] B) an open wound on the lower extremities. C) brownish or grayish discoloration of the skin. D) hard, waxy, hyperpigmented tissue with swelling of the surrounding areas.[netce.com]

  • Bronchitis

    Decreased levels of oxygen in the blood can also lead to peripheral edema, or swelling in the legs and ankles.[healthline.com]

    Missing: Antithrombin III Increased Discoloration of the Lower Extremity