Antinuclear Antibodies: Causes & Reasons

Possible Causes for Antinuclear Antibodies

Testing for antinuclear antibodies (ANA), antibodies to extractable nuclear antigen (antibodies to U1 ribonucleoprotein, or RNP), and Smith (Sm) and anti-DNA antibodies Organ [merckmanuals.com]

[…] disease collagen disease that is considered an overlap of three diseases, systemic lupus erythematosus, scleroderma, and polymyositis with very high titers of circulating antinuclear [wikidata.org]

However, evidence to date has revealed associated side effects, including antinuclear antibody induction and development of a lupus-like syndrome. [ncbi.nlm.nih.gov]

Chilblain Lupus Erythematosus Type 1

This joint involvement was accompanied by thrombocytopenia or lymphopenia and antinuclear antibodies. [jamanetwork.com]

Serologic workup revealed increased antinuclear antibody titers of 1:320 (reference range, <1:40) and anti-Ro/Sjögren syndrome antigen antibodies of 86 (reference range, < [mdedge.com]

Antinuclear antibody (ANA): Pernio lesions can occur in the setting of lupus erythematosus. [dermaamin.com]

Limited Cutaneous Systemic Scleroderma

The laboratory data showed weakly positive antinuclear antibody (ANA), and Topoisomerase 1 antibody (anti-Scl-70) titers. [ncbi.nlm.nih.gov]

Serology revealed positive antinuclear antibodies with a centromere staining pattern; subsequent rheumatology review revealed extensive telangiectasia with digital ulceration [ncbi.nlm.nih.gov]

Scleroderma sine scleroderma Presentation with pulmonary fibrosis or renal, cardiac, or gastrointestinal disease No skin involvement Raynaud phenomenon may be present Antinuclear [uofmhealth.org]

Raynaud Syndrome

antibodies (ANA) and ANA subsets were obtained at initial presentation. [ncbi.nlm.nih.gov]

antibodies, extractable antibodies, cold agglutinins, cryoglobulins, plasma and blood viscosity, erythrocyte aggregation and a nail fold capillaroscopy. [ncbi.nlm.nih.gov]

Subgroup analysis of IPPPG showed statistical significance in patients with negative fluorescent antinuclear antibody (P < .05). [ncbi.nlm.nih.gov]

Raynaud Disease

Antinuclear antibody test is done to analyze for the presence of antinuclear antibodies. [symptoma.com]

Blood tests such as sedimentation rate (ESR) and antinuclear antibodies (ANA) can assist in establishing a diagnosis of connective tissue disease. [evergreenhealth.com]

In addition, antinuclear antibody test is also done to assess the levels of the antibody. [symptoma.com]

Cronkhite-Canada Syndrome

Interestingly, the patient also had colon cancer, as well as portal thrombosis and a high concentration of antinuclear antibody. [ncbi.nlm.nih.gov]

Antinuclear antibodies were elevated. Gastrointestinal endoscopy and colonoscopy revealed the mucosa carpeted with strawberry-like polypoid lesions. [ncbi.nlm.nih.gov]

He had a past history of chronic pityriasis lichenoides, and serum antinuclear antibody was positive. [ncbi.nlm.nih.gov]

Juvenile Idiopathic Arthritis

This study was conducted to determine the frequency of antinuclear antibodies (ANA) positivity and uveitis in our newly diagnosed juvenile idiopathic arthritis (JIA) patients [ncbi.nlm.nih.gov]

However, many children with JIA do not have rheumatoid factor or antinuclear antibodies in their blood. [msdmanuals.com]

Children with JIA who have antinuclear antibodies in their blood are at a higher risk of developing iridocyclitis. [msdmanuals.com]

Polyarticular Juvenile Idiopathic Arthritis

Involvement of the small or upper extremity joints at disease diagnosis and MTX initiation was more frequent; antinuclear antibody (ANA) positivity was less frequent; acute [ncbi.nlm.nih.gov]

*The incidence of anterior uveitis increases when antinuclear antibodies (ANA) are present. [amboss.com]

Labs (often non-diagnostic) Precautions Rheumatoid Factor and Antinuclear Antibody are negative in more than 80% of juvenile RA Rheumatoid Factor Variably positive, often [fpnotebook.com]

Oligoarthritis

Retrospective assessments included sex, onset age, disease duration, antinuclear antibodies, HLA-B27, uveitis, ocular complications, second-line therapies, intraarticular [ncbi.nlm.nih.gov]

ANA: antinuclear antibody. Figure 5. [jrheum.org]

Gender, race, and antinuclear antibody (ANA) status were not significant risk factors. The visual outcome was favorable, with 90% achieving acuity of 6/12 or better. [ncbi.nlm.nih.gov]

Lupus Erythematosus

Doctors often use a test to check for antinuclear antibodies, the immune substances that attack your tissues. [stlukes-stl.com]

Tests used to diagnose SLE may include: Antinuclear antibody (ANA) Complete blood count (CBC) with differential Chest x-ray Serum creatinine Urinalysis You may also have other [medlineplus.gov]

Abbreviations: ACLA : anticardiolipin antibody ANA : antinuclear antibody APLS : antiphospholipid antibody syndrome ARF : acute rheumatic fever DIL : drug-induced lupus dsDNA [pedsinreview.aappublications.org]

Connective Tissue Disease

[…] for the presence of antinuclear antibodies (ANA) and for cyclic citrullinated peptide (CCP) antibodies. [mayocliniclabs.com]

We describe a 28-year-old man with linear atrophoderma of Moulin (LAM), whose serum immunological markers were abnormal (including antinuclear antibody, ribonucleoprotein, [ncbi.nlm.nih.gov]

Despite arthritis and myositis that required treatment, low level C3 and C4, positive antinuclear antibodies, and elevated anticardiolipin antibodies only once, in a follow-up [ncbi.nlm.nih.gov]

Systemic Lupus Erythematosus

The only proof to support the SLE is that we observed a weakly positive antinuclear antibody (ANA) in serum at the onset. [ncbi.nlm.nih.gov]

(2) any other autoimmune connective tissue disease, and/or (3) antinuclear antibodies >1/320. [ncbi.nlm.nih.gov]

Systemic Lupus Erythematosus with Organ/System Involvement

These antibodies are mostly antinuclear antibodies (ANA) that react with the body's own DNA leading to the formation of immune complexes that deposit on blood vessel walls [ypo.education]

Nearly all people with lupus have a positive test for antinuclear antibody (ANA). However, having a positive ANA alone does not mean you have lupus. [medlineplus.gov]

Psoriatic Juvenile Idiopathic Arthritis

antibodies. [ncbi.nlm.nih.gov]

Early-onset disease is characterized by female predominance, small joint involvement, dactylitis, and positive antinuclear antibodies. [ncbi.nlm.nih.gov]

[…] no difference in the percentage of patients between the oligoarticular groups who developed extended oligoarthritis or in the percentage of patients who were positive for antinuclear [ncbi.nlm.nih.gov]

Sjögren Syndrome

Serum antinuclear antibodies (ANA) were elevated (1 : 320). [ncbi.nlm.nih.gov]

Increased levels of antinuclear antibodies are also seen in both diseases. [lupus.org]

The distinction between fibromyalgia patients with low titer antinuclear antibodies and primary SS remains difficult. [ncbi.nlm.nih.gov]

Diffuse Cutaneous Systemic Scleroderma

Thus, the severity of organ manifestations varied not only with the form of PSS, but also with the absence/presence of antinuclear antibody. [ncbi.nlm.nih.gov]

In contrast to SSc, Raynaud's phenomenon and cutaneous calcinosis were absent and antinuclear antibodies were negative. [ncbi.nlm.nih.gov]

Sixty eight per cent of the patients with diffuse scleroderma and 62% of those with the CREST syndrome had a positive antinuclear antibody test, which was associated with [ncbi.nlm.nih.gov]

Systemic Scleroderma

RESULTS: Antinuclear antibodies (ANA) were detected in 94.2% of patients. [ncbi.nlm.nih.gov]

Antinuclear antibody titer and pattern were measured by indirect immunofluorescence with human epithelial (HEp)-2 cells and tissue sections, whereas anti-Scl-70 antibodies [ncbi.nlm.nih.gov]

While hypercoagulability including positive anticardiolipin antibodies was found in only 1 patient, all patients were antinuclear antibody (ANA) positive and 6 of 8 patients [ncbi.nlm.nih.gov]

Drug-Induced Lupus Erythematosus

The antinuclear antibody and antihistone antibody were positive. [doi.org]

Monocytes, one type of white blood cell, detect the antigen and relay the recognition to T helper cells, creating antinuclear antibodies leading to an immune response. [en.wikipedia.org]

Antinuclear antibodies are present. The patient had no history of SLE prior to using the culprit drug. [oralmaxillo-facialsurgery.blogspot.com]

Insulin-Resistance Syndrome Type B

Serological data showed that Ig G, Ig E and complement levels were near normal, and titer of antinuclear antibodies was decreased. [bmcendocrdisord.biomedcentral.com]

antibodies or decreased levels of certain complement factors). [orpha.net]

Based on the clinical features, presence of antinuclear antibodies, anti-RNP/Sm antibodies, and positive direct Coombs test diagnosis of mixed connective tissue disease/lupus [endocrine-abstracts.org]

Localized Scleroderma

Laboratory testing was positive for antinuclear antibody and a high serum creatine kinase level. [ncbi.nlm.nih.gov]

Anti-DNA and antinuclear antibodies negative, IgG anti Borrelia Burgdorferi antibodies were positive. [omicsonline.org]

Antibodies to B. burgdorferi and high antinuclear antibody titers have been described in patients with morphea, and it has been suggested that Borrelia -associated early-onset [omicsonline.org]

Juvenile Seronegative Polyarthritis

Labs (often non-diagnostic) Precautions Rheumatoid Factor and Antinuclear Antibody are negative in more than 80% of juvenile RA Rheumatoid Factor Variably positive, often [fpnotebook.com]

Laboratory tests such as ESR, rheumatoid factor ( RF ), antinuclear antibodies ( ANA ), and the HLA-B27 antigen test are used to classify and determine the prognosis of JIA [amboss.com]

The antinuclear antibody (ANA) test can be of value when clinical findings strongly suggest JRA. [news-medical.net]

Lupus Encephalitis

It has also been found that ultraviolet light can lead to the formation of antinuclear antibodies. [ncbi.nlm.nih.gov]

Serological tests for lupus antibodies include antinuclear antibodies (ANA), antiphospholipid antibodies, and anticardiolipin antibodies will be positive in patients with [symptoma.com]

Autoimmune Hepatitis

She was positive for antinuclear antibody, double stranded DNA antibody and LKM 1 antibody. [ncbi.nlm.nih.gov]

Blood tests showed high levels of liver enzymes, IgG, IgG4, and antinuclear antibody. [ncbi.nlm.nih.gov]

The diagnosis is established by detecting high titers of autoantibodies such as antinuclear antibodies, anti-smooth muscle antibodies, and elevated immunoglobulins. [ncbi.nlm.nih.gov]

Overlap Syndrome

Autoimmune hepatitis also known as Lupoid hepatitis is an autoimmune liver disease characterized by the presence of autoantibodies including antinuclear antibodies (ANA) and [ncbi.nlm.nih.gov]

Diagnostic work-up was remarkable for a positive antinuclear antibodies (ANA) test and a liver biopsy suggestive of an AIH-PBC overlap syndrome. [ncbi.nlm.nih.gov]

Hematology revealed elevated levels of hepatobiliary enzymes and positive results for antinuclear antibody (ANA) and antimitochondrial (AMA) M2 antibody. [ncbi.nlm.nih.gov]

Systemic Juvenile Idiopathic Arthritis

Autoimmune and infective serological tests (eg, viral hepatitis tests, anti-immunodeficiency virus antibody, antinuclear antibody rheumatoid factor and mononuclesosis antibodies [scielo.br]

Results of antinuclear antibody, ANCA, rheumatoid factor, and anti-cyclic citrullinated peptide tests were also negative. [medscape.com]

Labs (often non-diagnostic) Precautions Rheumatoid Factor and Antinuclear Antibody are negative in more than 80% of juvenile RA Rheumatoid Factor Variably positive, often [fpnotebook.com]

Primary Biliary Cirrhosis

Moreover, several types of antinuclear antibodies have been associated with primary biliary cirrhosis. [ncbi.nlm.nih.gov]

Detection of antinuclear antibodies at a titer of 1/800, anti-SSA, anti-SSB, anti-GP210, anti-microsomial and p-ANCA anti-myeloperoxydase antibodies along with renal, salivary [ncbi.nlm.nih.gov]

Hematology revealed elevated levels of hepatobiliary enzymes and positive results for antinuclear antibody (ANA) and antimitochondrial (AMA) M2 antibody. [ncbi.nlm.nih.gov]

Discoid Lupus Erythematosus

In rare instances, laboratory tests show inflammation associated with low titers of antinuclear antibodies. [escholarship.org]

Antinuclear antibody (ANA) titer was 1/160 with speckled pattern. She was treated by oral hydroxychloroquine (400 mg daily) with moderate improvement after three months. [ncbi.nlm.nih.gov]

Full blood count, CRP, ESR Creatinine, ALT, alkaline phosphatase Urinalysis Serum antinuclear antibody analysis, antibodies to extractable nuclear antigens, DNA antibodies [ebm-guidelines.com]

Adult-Onset Still Disease

antibody as minor criteria. [ncbi.nlm.nih.gov]

Tests for antinuclear antibody and rheumatoid factor were negative. The serum ferritin was 6364.09 ng/ml. [tropicalgastro.com]

Additionally, rheumatoid factor (RF) and antinuclear antibodies (ANA), both performed to exclude conditions such as rheumatoid arthritis (RA) and systemic lupus erythematosus [symptoma.com]

Autoimmune Disease

Based on a slight elevation of antinuclear antibody level, autoimmune disease was suspected to be involved in this patient. [ncbi.nlm.nih.gov]

Serological testing is commonly used to detect autoantibodies, such as antinuclear antibodies (ANA’s) anti-extractable nuclear antigens (ENA’s) and other autoimmune associated [mblintl.com]

Tests used for this purpose include: Antinuclear antibody tests – tests that looks for antibodies that attack the nuclei of cells in your body (antinuclear antibodies) Autoantibody [diabetes.co.uk]

Pemphigus Erythematosus

antibody findings corresponded to pemphigus erythematosus. [ncbi.nlm.nih.gov]

All four patients had positive antinuclear antibody tests (ANA), but anti-deoxyribonucleic acid (DNA) and anti-extractable nuclear antigens (ENA) were negative. [ncbi.nlm.nih.gov]

Pemphigus antibodies, occasionally antinuclear antibodies. Diagnosis This section has been translated automatically. Light stairs ( MED), DIF after UV provocation. [altmeyers.org]