Possible Causes for antinuclear antibodies Raynaud Syndrome antibodies (ANA) and ANA subsets were obtained at initial presentation. [ncbi.nlm.nih.gov] antibodies, extractable antibodies, cold agglutinins, cryoglobulins, plasma and blood viscosity, erythrocyte aggregation and a nail fold capillaroscopy. [ncbi.nlm.nih.gov] Subgroup analysis of IPPPG showed statistical significance in patients with negative fluorescent antinuclear antibody (P .05). [ncbi.nlm.nih.gov] Raynaud Disease Antinuclear antibody test is done to analyze for the presence of antinuclear antibodies. [symptoma.com] Blood tests such as sedimentation rate (ESR) and antinuclear antibodies (ANA) can assist in establishing a diagnosis of connective tissue disease. [evergreenhealth.com] In addition, antinuclear antibody test is also done to assess the levels of the antibody. [symptoma.com] Mixed Connective Tissue Disease […] disease collagen disease that is considered an overlap of three diseases, systemic lupus erythematosus, scleroderma, and polymyositis with very high titers of circulating antinuclear [wikidata.org] However, evidence to date has revealed associated side effects, including antinuclear antibody induction and development of a lupus-like syndrome. [ncbi.nlm.nih.gov] Testing for antinuclear antibodies (ANA), antibodies to extractable nuclear antigen (antibodies to U1 ribonucleoprotein, or RNP), and Smith (Sm) and anti-DNA antibodies Organ [merckmanuals.com] Cronkhite-Canada Syndrome Interestingly, the patient also had colon cancer, as well as portal thrombosis and a high concentration of antinuclear antibody. [ncbi.nlm.nih.gov] Antinuclear antibodies were elevated. Gastrointestinal endoscopy and colonoscopy revealed the mucosa carpeted with strawberry-like polypoid lesions. [ncbi.nlm.nih.gov] He had a past history of chronic pityriasis lichenoides, and serum antinuclear antibody was positive. [ncbi.nlm.nih.gov] Limited Cutaneous Systemic Scleroderma The laboratory data showed weakly positive antinuclear antibody (ANA), and Topoisomerase 1 antibody (anti-Scl-70) titers. [ncbi.nlm.nih.gov] Serology revealed positive antinuclear antibodies with a centromere staining pattern; subsequent rheumatology review revealed extensive telangiectasia with digital ulceration [ncbi.nlm.nih.gov] Scleroderma sine scleroderma Presentation with pulmonary fibrosis or renal, cardiac, or gastrointestinal disease No skin involvement Raynaud phenomenon may be present Antinuclear [uofmhealth.org] Juvenile Idiopathic Arthritis This study was conducted to determine the frequency of antinuclear antibodies (ANA) positivity and uveitis in our newly diagnosed juvenile idiopathic arthritis (JIA) patients [ncbi.nlm.nih.gov] One case in each group had antinuclear antibody positivity. It can be concluded that ALL can masquerade as systematic onset of JRA. [ncbi.nlm.nih.gov] Morbach_H@klinik.uni-wuerzburg.de Abstract The frequent appearance of antinuclear antibodies in patients with juvenile rheumatoid arthritis (JRA) indicates a loss of tolerance [ncbi.nlm.nih.gov] Chilblain Lupus Erythematosus Type 1 Antinuclear antibody (ANA): Pernio lesions can occur in the setting of lupus erythematosus. [dermaamin.com] The diagnosis of CHLE was further confirmed by positive antinuclear antibodies as well as by skin biopsy and direct immunofluorescence. [idoj.in] […] described in literature.[ 6 ] In most patients, immunological abnormalities are frequently observed in the form of polyclonal hypergammaglobulinemia, raised rheumatoid factor, antinuclear [ncbi.nlm.nih.gov] Polyarticular Juvenile Idiopathic Arthritis Involvement of the small or upper extremity joints at disease diagnosis and MTX initiation was more frequent; antinuclear antibody (ANA) positivity was less frequent; acute [ncbi.nlm.nih.gov] Nine (42.9%) MTX and 48 ADA MTX (72.7%) pts were positive for antinuclear antibodies at registry enrollment. [acrabstracts.org] Usefulness of antinuclear antibody testing to screen for rheumatic diseases. Arch Dis Child. 1997;77(4):299–304. doi:10.1136/adc.77.4.299 [CrossRef] Rabinovich CE. [healio.com] Connective Tissue Disease We describe a 28-year-old man with linear atrophoderma of Moulin (LAM), whose serum immunological markers were abnormal (including antinuclear antibody, ribonucleoprotein, [ncbi.nlm.nih.gov] Despite arthritis and myositis that required treatment, low level C3 and C4, positive antinuclear antibodies, and elevated anticardiolipin antibodies only once, in a follow-up [ncbi.nlm.nih.gov] A pathological diagnosis suggested careful follow-up with extensive immunological screening which then detected Raynaud's phenomenon and positivity of antinuclear antibodies [ncbi.nlm.nih.gov] Lupus Erythematosus Before gastrectomy, laboratory examination results showed renal dysfunction, hypocomplementemia, antinuclear antibodies (ANAs) positivity, and elevated serum IgG and IgG4 [ncbi.nlm.nih.gov] Abbreviations: ACLA : anticardiolipin antibody ANA : antinuclear antibody APLS : antiphospholipid antibody syndrome ARF : acute rheumatic fever DIL : drug-induced lupus dsDNA [pedsinreview.aappublications.org] Understand the meaning of a positive antinuclear antibody. Understand the serologic markers associated with SLE. [pedsinreview.aappublications.org] Oligoarthritis Retrospective assessments included sex, onset age, disease duration, antinuclear antibodies, HLA-B27, uveitis, ocular complications, second-line therapies, intraarticular [ncbi.nlm.nih.gov] ANA: antinuclear antibody. Figure 5. [jrheum.org] Gender, race, and antinuclear antibody (ANA) status were not significant risk factors. The visual outcome was favorable, with 90% achieving acuity of 6/12 or better. [ncbi.nlm.nih.gov] Polyarthritis Rheumatoid factor, anticyclic citrullinated protein antibody, antinuclear antibodies, anti-Borrelia, and burgdorferi antibodies were all negative, and myoglobin and calcitonin [ncbi.nlm.nih.gov] Specificity increases with consistent results on more than 1 test and with high titre.4 The presence of antinuclear antibodies at a low titre may be associated with more severe [cmaj.ca] Specificity increases with consistent results on more than 1 test and with high titre. 4 The presence of antinuclear antibodies at a low titre may be associated with more [cmaj.ca] Systemic Lupus Erythematosus The only proof to support the SLE is that we observed a weakly positive antinuclear antibody (ANA) in serum at the onset. [ncbi.nlm.nih.gov] (2) any other autoimmune connective tissue disease, and/or (3) antinuclear antibodies 1/320. [ncbi.nlm.nih.gov] KEYWORDS: Antinuclear antibody; Jaccoud arthropathy; Lupus nephritis; Malar rash; Pericarditis; Pleuritis; Systemic lupus erythematosus [ncbi.nlm.nih.gov] Psoriatic Juvenile Idiopathic Arthritis antibodies. [ncbi.nlm.nih.gov] Early-onset disease is characterized by female predominance, small joint involvement, dactylitis, and positive antinuclear antibodies. [ncbi.nlm.nih.gov] […] no difference in the percentage of patients between the oligoarticular groups who developed extended oligoarthritis or in the percentage of patients who were positive for antinuclear [ncbi.nlm.nih.gov] Sjögren Syndrome Serum antinuclear antibodies (ANA) were elevated (1 : 320). [ncbi.nlm.nih.gov] The distinction between fibromyalgia patients with low titer antinuclear antibodies and primary SS remains difficult. [ncbi.nlm.nih.gov] The problems of diagnosis are further compounded by the finding of “positive” antinuclear antibodies in a high percent of the general population. [doi.org] Drug-Induced Lupus Erythematosus Monocytes, one type of white blood cell, detect the antigen and relay the recognition to T helper cells, creating antinuclear antibodies leading to an immune response. [en.wikipedia.org] […] who were symptomatic from a drug-induced lupus-like illness (DILE) and asymptomatic patients who had drug-induced antinuclear antibodies (DANA). [ncbi.nlm.nih.gov] The syndrome is characterised by arthralgia, myalgia, pleurisy, rash and fever in association with antinuclear antibodies in the serum. [ncbi.nlm.nih.gov] Localized Scleroderma Laboratory testing was positive for antinuclear antibody and a high serum creatine kinase level. [ncbi.nlm.nih.gov] Laboratory testing was positive for antinuclear antibody test at 1: 640 but negative for anti-SS-A/B, anti-U1-RNP, anti-DNA, anti-Sm, anticentromere, anti-topoisomerase I [ncbi.nlm.nih.gov] Antinuclear antibodies (ANA), anti-histone and rheumatoid factor are detected in high rate of morphea cases. Scleroderma-related antibodies are usually absent. [ncbi.nlm.nih.gov] Autoimmune Hepatitis She was positive for antinuclear antibody, double stranded DNA antibody and LKM 1 antibody. [ncbi.nlm.nih.gov] Blood tests showed high levels of liver enzymes, IgG, IgG4, and antinuclear antibody. [ncbi.nlm.nih.gov] The diagnosis is established by detecting high titers of autoantibodies such as antinuclear antibodies, anti-smooth muscle antibodies, and elevated immunoglobulins. [ncbi.nlm.nih.gov] Systemic Lupus Erythematosus with Organ/System Involvement Abbreviations: ACLA : anticardiolipin antibody ANA : antinuclear antibody APLS : antiphospholipid antibody syndrome ARF : acute rheumatic fever DIL : drug-induced lupus dsDNA [pedsinreview.aappublications.org] Antinuclear antibody An abnormal titer of antinuclear antibody by immunofluorescence or an equivalent assay at any point in time and in the absence of drugs known to be associated [pedclerk.bsd.uchicago.edu] Although a positive antinuclear antibodies (ANA) lab result is generally required to make the diagnosis, there are many children with positive ANAs who do not have lupus. [resources.lupus.org] Insulin-Resistance Syndrome Type B antibodies or decreased levels of certain complement factors). [orpha.net] Based on the clinical features, presence of antinuclear antibodies, anti-RNP/Sm antibodies, and positive direct Coombs test diagnosis of mixed connective tissue disease/lupus [endocrine-abstracts.org] Serological data showed that Ig G, Ig E and complement levels were near normal, and titer of antinuclear antibodies was decreased. [bmcendocrdisord.biomedcentral.com] Diffuse Cutaneous Systemic Scleroderma Thus, the severity of organ manifestations varied not only with the form of PSS, but also with the absence/presence of antinuclear antibody. [ncbi.nlm.nih.gov] In contrast to SSc, Raynaud's phenomenon and cutaneous calcinosis were absent and antinuclear antibodies were negative. [ncbi.nlm.nih.gov] Sixty eight per cent of the patients with diffuse scleroderma and 62% of those with the CREST syndrome had a positive antinuclear antibody test, which was associated with [ncbi.nlm.nih.gov] Systemic Scleroderma Antinuclear antibody titer and pattern were measured by indirect immunofluorescence with human epithelial (HEp)-2 cells and tissue sections, whereas anti-Scl-70 antibodies [ncbi.nlm.nih.gov] RESULTS: Antinuclear antibodies (ANA) were detected in 94.2% of patients. [ncbi.nlm.nih.gov] While hypercoagulability including positive anticardiolipin antibodies was found in only 1 patient, all patients were antinuclear antibody (ANA) positive and 6 of 8 patients [ncbi.nlm.nih.gov] Lupus Encephalitis It has also been found that ultraviolet light can lead to the formation of antinuclear antibodies. [ncbi.nlm.nih.gov] Serological tests for lupus antibodies include antinuclear antibodies (ANA), antiphospholipid antibodies, and anticardiolipin antibodies will be positive in patients with [symptoma.com] Additional tests were positive for antinuclear antibodies (ANA) and anti-DNA antibodies, elevated myoglobin, and low complement 3 and 4. [healio.com] Overlap Syndrome Autoimmune hepatitis also known as Lupoid hepatitis is an autoimmune liver disease characterized by the presence of autoantibodies including antinuclear antibodies (ANA) and [ncbi.nlm.nih.gov] Diagnostic work-up was remarkable for a positive antinuclear antibodies (ANA) test and a liver biopsy suggestive of an AIH-PBC overlap syndrome. [ncbi.nlm.nih.gov] Hematology revealed elevated levels of hepatobiliary enzymes and positive results for antinuclear antibody (ANA) and antimitochondrial (AMA) M2 antibody. [ncbi.nlm.nih.gov] Lupus Nephritis Literature review on antinuclear antibody (ANA)-negative and seronegative LN revealed the following patient presentations: (1) renal-limited or renal and extra-renal manifestations [ncbi.nlm.nih.gov] This study aimed to determine the clinical manifestations and Antinuclear Antibodies (ANA) profile among Sudanese adults with SLE and lupus nephritis (LN). [ncbi.nlm.nih.gov] Malleson PN, Sailer M, Mackinnon MJ: Usefulness of antinuclear antibody testing to screen for rheumatic diseases. [karger.com] Primary Biliary Cirrhosis Moreover, several types of antinuclear antibodies have been associated with primary biliary cirrhosis. [ncbi.nlm.nih.gov] Detection of antinuclear antibodies at a titer of 1/800, anti-SSA, anti-SSB, anti-GP210, anti-microsomial and p-ANCA anti-myeloperoxydase antibodies along with renal, salivary [ncbi.nlm.nih.gov] Hematology revealed elevated levels of hepatobiliary enzymes and positive results for antinuclear antibody (ANA) and antimitochondrial (AMA) M2 antibody. [ncbi.nlm.nih.gov] Juvenile Seronegative Polyarthritis Labs (often non-diagnostic) Precautions Rheumatoid Factor and Antinuclear Antibody are negative in more than 80% of juvenile RA Rheumatoid Factor Variably positive, often [fpnotebook.com] Laboratory tests such as ESR, rheumatoid factor ( RF ), antinuclear antibodies ( ANA ), and the HLA-B27 antigen test are used to classify and determine the prognosis of JIA [amboss.com] The antinuclear antibody (ANA) test can be of value when clinical findings strongly suggest JRA. [news-medical.net] Juvenile-Onset Still Disease However, the classic blood tests for rheumatoid arthritis (rheumatoid factor) and systemic lupus erythematosus (antinuclear antibodies) are usually negative. [medicinenet.com] Autoimmune and infective serological tests (eg, viral hepatitis tests, anti-immunodeficiency virus antibody, antinuclear antibody rheumatoid factor and mononuclesosis antibodies [scielo.br] Results of antinuclear antibody, ANCA, rheumatoid factor, and anti-cyclic citrullinated peptide tests were also negative. [medscape.com] Discoid Lupus Erythematosus Antinuclear antibody (ANA) titer was 1/160 with speckled pattern. She was treated by oral hydroxychloroquine (400 mg daily) with moderate improvement after three months. [ncbi.nlm.nih.gov] In rare instances, laboratory tests show inflammation associated with low titers of antinuclear antibodies. [escholarship.org] Full blood count, CRP, ESR Creatinine, ALT, alkaline phosphatase Urinalysis Serum antinuclear antibody analysis, antibodies to extractable nuclear antigens, DNA antibodies [ebm-guidelines.com] Vasculitis The main immunological tests are Antinuclear antibody (ANA – for SLE a connective tissue diseases) and Anti-neutrophil cytoplasmic antibody (ANCA – Wegener’s granulomatosis [mft.nhs.uk] Analysis of the patient's serum revealed the presence of antinuclear antibodies that were already present before starting PD-1 blockade. [ncbi.nlm.nih.gov] Immunological findings may sometimes include raised ESR/CRP, depressed levels of complement factors suggesting consumption, and the presence of antinuclear antibodies and [mft.nhs.uk]
