Antinuclear Antibodies: Causes & Reasons

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Possible Causes for Antinuclear Antibodies

Mixed Connective Tissue Disease

Testing for antinuclear antibodies (ANA), antibodies to extractable nuclear antigen (antibodies to U1 ribonucleoprotein, or RNP), and Smith (Sm) and anti-DNA antibodies Organ [merckmanuals.com]

[…] disease collagen disease that is considered an overlap of three diseases, systemic lupus erythematosus, scleroderma, and polymyositis with very high titers of circulating antinuclear [wikidata.org]

However, evidence to date has revealed associated side effects, including antinuclear antibody induction and development of a lupus-like syndrome. [ncbi.nlm.nih.gov]

Limited Cutaneous Systemic Scleroderma

The laboratory data showed weakly positive antinuclear antibody (ANA), and Topoisomerase 1 antibody (anti-Scl-70) titers. [ncbi.nlm.nih.gov]

Serology revealed positive antinuclear antibodies with a centromere staining pattern; subsequent rheumatology review revealed extensive telangiectasia with digital ulceration [ncbi.nlm.nih.gov]

Scleroderma sine scleroderma Presentation with pulmonary fibrosis or renal, cardiac, or gastrointestinal disease No skin involvement Raynaud phenomenon may be present Antinuclear [uofmhealth.org]

Chilblain Lupus Erythematosus Type 1

Antinuclear antibody (ANA): Pernio lesions can occur in the setting of lupus erythematosus. [dermaamin.com]

The diagnosis of CHLE was further confirmed by positive antinuclear antibodies as well as by skin biopsy and direct immunofluorescence. [idoj.in]

[…] described in literature.[ 6 ] In most patients, immunological abnormalities are frequently observed in the form of polyclonal hypergammaglobulinemia, raised rheumatoid factor, antinuclear [ncbi.nlm.nih.gov]

Raynaud Syndrome

antibodies (ANA) and ANA subsets were obtained at initial presentation. [ncbi.nlm.nih.gov]

antibodies, extractable antibodies, cold agglutinins, cryoglobulins, plasma and blood viscosity, erythrocyte aggregation and a nail fold capillaroscopy. [ncbi.nlm.nih.gov]

Subgroup analysis of IPPPG showed statistical significance in patients with negative fluorescent antinuclear antibody (P < .05). [ncbi.nlm.nih.gov]

Raynaud Disease

Antinuclear antibody test is done to analyze for the presence of antinuclear antibodies. [symptoma.com]

Blood tests such as sedimentation rate (ESR) and antinuclear antibodies (ANA) can assist in establishing a diagnosis of connective tissue disease. [evergreenhealth.com]

In addition, antinuclear antibody test is also done to assess the levels of the antibody. [symptoma.com]

Polyarthritis

Rheumatoid factor, anticyclic citrullinated protein antibody, antinuclear antibodies, anti-Borrelia, and burgdorferi antibodies were all negative, and myoglobin and calcitonin [ncbi.nlm.nih.gov]

Laboratory Tests ANTINUCLEAR ANTIBODY SLE without antinuclear antibodies comprises less than 2% of cases; therefore, SLE is unlikely in a patient with polyarthritis who tests [aafp.org]

Ascertainment of antinuclear antibodies is a very sensitive but little specific approach to SLE diagnosis. [symptoma.com]

Cronkhite-Canada Syndrome

Interestingly, the patient also had colon cancer, as well as portal thrombosis and a high concentration of antinuclear antibody. [ncbi.nlm.nih.gov]

He had a past history of chronic pityriasis lichenoides, and serum antinuclear antibody was positive. [ncbi.nlm.nih.gov]

Anti-Saccharomyces cerevisiae and antinuclear antibodies were present in three cases. [ncbi.nlm.nih.gov]

Juvenile Idiopathic Arthritis

This study was conducted to determine the frequency of antinuclear antibodies (ANA) positivity and uveitis in our newly diagnosed juvenile idiopathic arthritis (JIA) patients [ncbi.nlm.nih.gov]

However, many children with JIA do not have rheumatoid factor or antinuclear antibodies in their blood. [merckmanuals.com]

Children with JIA who have antinuclear antibodies in their blood are at a higher risk of developing iridocyclitis. [merckmanuals.com]

Polyarticular Juvenile Idiopathic Arthritis

Involvement of the small or upper extremity joints at disease diagnosis and MTX initiation was more frequent; antinuclear antibody (ANA) positivity was less frequent; acute [ncbi.nlm.nih.gov]

*The incidence of anterior uveitis increases when antinuclear antibodies (ANA) are present. [amboss.com]

Labs (often non-diagnostic) Precautions Rheumatoid Factor and Antinuclear Antibody are negative in more than 80% of juvenile RA Rheumatoid Factor Variably positive, often [fpnotebook.com]

Connective Tissue Disease

[…] for the presence of antinuclear antibodies (ANA) and for cyclic citrullinated peptide (CCP) antibodies. [mayocliniclabs.com]

We describe a 28-year-old man with linear atrophoderma of Moulin (LAM), whose serum immunological markers were abnormal (including antinuclear antibody, ribonucleoprotein, [ncbi.nlm.nih.gov]

Despite arthritis and myositis that required treatment, low level C3 and C4, positive antinuclear antibodies, and elevated anticardiolipin antibodies only once, in a follow-up [ncbi.nlm.nih.gov]

Oligoarthritis

Retrospective assessments included sex, onset age, disease duration, antinuclear antibodies, HLA-B27, uveitis, ocular complications, second-line therapies, intraarticular [ncbi.nlm.nih.gov]

ANA: antinuclear antibody. Figure 5. [jrheum.org]

Gender, race, and antinuclear antibody (ANA) status were not significant risk factors. The visual outcome was favorable, with 90% achieving acuity of 6/12 or better. [ncbi.nlm.nih.gov]

Lupus Erythematosus

Abbreviations: ACLA : anticardiolipin antibody ANA : antinuclear antibody APLS : antiphospholipid antibody syndrome ARF : acute rheumatic fever DIL : drug-induced lupus dsDNA [pedsinreview.aappublications.org]

Autoantibodies called antinuclear antibodies (those that bind to the nucleic acid and protein constituents of cell nuclei) are found in nearly all individuals with systemic [britannica.com]

Understand the meaning of a positive antinuclear antibody. Understand the serologic markers associated with SLE. [pedsinreview.aappublications.org]

Diffuse Cutaneous Systemic Scleroderma

Thus, the severity of organ manifestations varied not only with the form of PSS, but also with the absence/presence of antinuclear antibody. [ncbi.nlm.nih.gov]

In contrast to SSc, Raynaud's phenomenon and cutaneous calcinosis were absent and antinuclear antibodies were negative. [ncbi.nlm.nih.gov]

Sixty eight per cent of the patients with diffuse scleroderma and 62% of those with the CREST syndrome had a positive antinuclear antibody test, which was associated with [ncbi.nlm.nih.gov]

Vasculitis

The main immunological tests are Antinuclear antibody (ANA – for SLE a connective tissue diseases) and Anti-neutrophil cytoplasmic antibody (ANCA – Wegener’s granulomatosis [mft.nhs.uk]

Analysis of the patient's serum revealed the presence of antinuclear antibodies that were already present before starting PD-1 blockade. [ncbi.nlm.nih.gov]

Immunological findings may sometimes include raised ESR/CRP, depressed levels of complement factors suggesting consumption, and the presence of antinuclear antibodies and [mft.nhs.uk]

Systemic Scleroderma

RESULTS: Antinuclear antibodies (ANA) were detected in 94.2% of patients. [ncbi.nlm.nih.gov]

Antinuclear antibody titer and pattern were measured by indirect immunofluorescence with human epithelial (HEp)-2 cells and tissue sections, whereas anti-Scl-70 antibodies [ncbi.nlm.nih.gov]

While hypercoagulability including positive anticardiolipin antibodies was found in only 1 patient, all patients were antinuclear antibody (ANA) positive and 6 of 8 patients [ncbi.nlm.nih.gov]

Systemic Lupus Erythematosus

The only proof to support the SLE is that we observed a weakly positive antinuclear antibody (ANA) in serum at the onset. [ncbi.nlm.nih.gov]

(2) any other autoimmune connective tissue disease, and/or (3) antinuclear antibodies >1/320. [ncbi.nlm.nih.gov]

Systemic Lupus Erythematosus with Organ/System Involvement

Antinuclear antibody An abnormal titer of antinuclear antibody by immunofluorescence or an equivalent assay at any point in time and in the absence of drugs known to be associated [pedclerk.bsd.uchicago.edu]

Although a positive antinuclear antibodies (ANA) lab result is generally required to make the diagnosis, there are many children with positive ANAs who do not have lupus. [resources.lupus.org]

Idiosyncratic Drug-Induced Liver Injury

Hepatitis B surface antigen, hepatitis C virus antibody, antinuclear antibody, and antimitochondrial antibody were undetectable. [care.diabetesjournals.org]

Investigations may also need to include an assessment for other causes of hepatitis and may include hepatitis viral serology, antinuclear antibodies, copper and iron levels [patient.info]

C-reactive protein Consider NSAIDs, antihistamines, or systemic corticosteroids; or plasmapheresis if severe. 18 Immune complexes Complement studies Antinuclear antibody, [aafp.org]

Psoriatic Juvenile Idiopathic Arthritis

antibodies. [ncbi.nlm.nih.gov]

Early-onset disease is characterized by female predominance, small joint involvement, dactylitis, and positive antinuclear antibodies. [ncbi.nlm.nih.gov]

[…] no difference in the percentage of patients between the oligoarticular groups who developed extended oligoarthritis or in the percentage of patients who were positive for antinuclear [ncbi.nlm.nih.gov]

Sjögren Syndrome

The distinction between fibromyalgia patients with low titer antinuclear antibodies and primary SS remains difficult. [ncbi.nlm.nih.gov]

The problems of diagnosis are further compounded by the finding of “positive” antinuclear antibodies in a high percent of the general population. [doi.org]

SLE was finally diagnosed based on bilateral lower limb skin rash, gonarthritis and omarthritis, low level of complement, antinuclear antibody 1:640 and positive antibodies [ncbi.nlm.nih.gov]

Insulin-Resistance Syndrome Type B

antibodies or decreased levels of certain complement factors). [orpha.net]

Based on the clinical features, presence of antinuclear antibodies, anti-RNP/Sm antibodies, and positive direct Coombs test diagnosis of mixed connective tissue disease/lupus [endocrine-abstracts.org]

Twelve patients had leukopenia, high titers of antinuclear antibodies (speckled pattern), and hypoalbuminemia; 11 had elevated serum levels of IgG and high erythrocyte sedimentation [annals.org]

Drug-Induced Lupus Erythematosus

The antinuclear antibody and antihistone antibody were positive. [doi.org]

Monocytes, one type of white blood cell, detect the antigen and relay the recognition to T helper cells, creating antinuclear antibodies leading to an immune response. [en.wikipedia.org]

[…] who were symptomatic from a drug-induced lupus-like illness (DILE) and asymptomatic patients who had drug-induced antinuclear antibodies (DANA). [ncbi.nlm.nih.gov]

Lupus Encephalitis

It has also been found that ultraviolet light can lead to the formation of antinuclear antibodies. [ncbi.nlm.nih.gov]

Serological tests for lupus antibodies include antinuclear antibodies (ANA), antiphospholipid antibodies, and anticardiolipin antibodies will be positive in patients with [symptoma.com]

Leukocytoclastic Vasculitis

Tests to consider include a complete blood count, urinalysis, serum chemistry panel, rheumatoid factor, hepatitis panel, HIV serology, antinuclear antibodies, and chest radiograph [aocd.org]

eosinophil counts; M-component; cryoglobulins; antinuclear antibodies; IgM/IgA rheumatoid factor; anti-cardiolipin antibodies; and anti-neutrophil cytoplasmic antibodies [care.diabetesjournals.org]

Serologic tests for antineutrophil cytoplasmic autoantibodies, antinuclear antibodies, complement, rheumatoid factor, and C-reactive protein were negative. [journals.lww.com]

Localized Scleroderma

Laboratory testing was positive for antinuclear antibody and a high serum creatine kinase level. [ncbi.nlm.nih.gov]

Anti-DNA and antinuclear antibodies negative, IgG anti Borrelia Burgdorferi antibodies were positive. [omicsonline.org]

Antibodies to B. burgdorferi and high antinuclear antibody titers have been described in patients with morphea, and it has been suggested that Borrelia -associated early-onset [omicsonline.org]

Juvenile Seronegative Polyarthritis

Labs (often non-diagnostic) Precautions Rheumatoid Factor and Antinuclear Antibody are negative in more than 80% of juvenile RA Rheumatoid Factor Variably positive, often [fpnotebook.com]

Laboratory tests such as ESR, rheumatoid factor ( RF ), antinuclear antibodies ( ANA ), and the HLA-B27 antigen test are used to classify and determine the prognosis of JIA [amboss.com]

The antinuclear antibody (ANA) test can be of value when clinical findings strongly suggest JRA. [news-medical.net]

Nitrofurantoin Toxicity

Prolonged elevation of liver enzyme concentrations together with the presence of increased antibody titers (anti-smooth muscle antibody, antinuclear antibody) was suggestive [ncbi.nlm.nih.gov]

Auto-immune laboratory findings including the antinuclear antibody and rheumatoid factor tests were negative. [f1000research.com]

antibodies (ANA) are more common in subacute (80%) versus acute (60%). [microbiologynutsandbolts.co.uk]

Lupus Nephritis

Antinuclear antibodies were strongly positive, including anti-double stranded DNA. Renal biopsy confirmed severe grade IV lupus nephritis. [ncbi.nlm.nih.gov]

Autoantibody tests were positive for antinuclear antibodies and anti-double-stranded DNA, and complement levels were markedly reduced. [ncbi.nlm.nih.gov]

The clinical picture, the negativity of antihistone antibodies, the nondisappearance of antinuclear antibodies after discontinuation of the drug, and the clinical stability [ncbi.nlm.nih.gov]

Autoimmune Hepatitis

She was positive for antinuclear antibody, double stranded DNA antibody and LKM 1 antibody. [ncbi.nlm.nih.gov]

Blood tests showed high levels of liver enzymes, IgG, IgG4, and antinuclear antibody. [ncbi.nlm.nih.gov]

The diagnosis is established by detecting high titers of autoantibodies such as antinuclear antibodies, anti-smooth muscle antibodies, and elevated immunoglobulins. [ncbi.nlm.nih.gov]

Bilateral Leg Weakness

Antinuclear antibody, rheumatoid factor, and erythrocyte sedimentation rate tests showed no abnormalities. [healio.com]

Antinuclear antibody was negative. Immunoglobulin A was 245 mg/dL. LP revealed clear and colorless cerebrospinal fluid (CSF) and RBC 1 mm 3. [clinicaladvisor.com]

antinuclear antibodies, and rheumatoid factor were all normal or negative. [n.neurology.org]