Antinuclear Antibodies: Causes & Reasons

Possible Causes for Antinuclear Antibodies

[…] disease collagen disease that is considered an overlap of three diseases, systemic lupus erythematosus, scleroderma, and polymyositis with very high titers of circulating antinuclear [wikidata.org]

Testing for antinuclear antibodies (ANA), antibodies to extractable nuclear antigen (antibodies to U1 ribonucleoprotein, or RNP), and Smith (Sm) and anti-DNA antibodies Organ [merckmanuals.com]

However, evidence to date has revealed associated side effects, including antinuclear antibody induction and development of a lupus-like syndrome. [ncbi.nlm.nih.gov]

Limited Cutaneous Systemic Scleroderma

The laboratory data showed weakly positive antinuclear antibody (ANA), and Topoisomerase 1 antibody (anti-Scl-70) titers. [ncbi.nlm.nih.gov]

Serology revealed positive antinuclear antibodies with a centromere staining pattern; subsequent rheumatology review revealed extensive telangiectasia with digital ulceration [ncbi.nlm.nih.gov]

Scleroderma sine scleroderma Presentation with pulmonary fibrosis or renal, cardiac, or gastrointestinal disease No skin involvement Raynaud phenomenon may be present Antinuclear [uofmhealth.org]

Chilblain Lupus Erythematosus Type 1

The diagnosis of CHLE was further confirmed by positive antinuclear antibodies as well as by skin biopsy and direct immunofluorescence. [idoj.in]

This joint involvement was accompanied by thrombocytopenia or lymphopenia and antinuclear antibodies. [jamanetwork.com]

[…] described in literature.[ 6 ] In most patients, immunological abnormalities are frequently observed in the form of polyclonal hypergammaglobulinemia, raised rheumatoid factor, antinuclear [ncbi.nlm.nih.gov]

Raynaud Syndrome

antibodies (ANA) and ANA subsets were obtained at initial presentation. [ncbi.nlm.nih.gov]

antibodies, extractable antibodies, cold agglutinins, cryoglobulins, plasma and blood viscosity, erythrocyte aggregation and a nail fold capillaroscopy. [ncbi.nlm.nih.gov]

Subgroup analysis of IPPPG showed statistical significance in patients with negative fluorescent antinuclear antibody (P < .05). [ncbi.nlm.nih.gov]

Raynaud Disease

Antinuclear antibody test is done to analyze for the presence of antinuclear antibodies. [symptoma.com]

Blood tests such as sedimentation rate (ESR) and antinuclear antibodies (ANA) can assist in establishing a diagnosis of connective tissue disease. [evergreenhealth.com]

In addition, antinuclear antibody test is also done to assess the levels of the antibody. [symptoma.com]

Cronkhite-Canada Syndrome

Interestingly, the patient also had colon cancer, as well as portal thrombosis and a high concentration of antinuclear antibody. [ncbi.nlm.nih.gov]

Antinuclear antibodies were elevated. Gastrointestinal endoscopy and colonoscopy revealed the mucosa carpeted with strawberry-like polypoid lesions. [ncbi.nlm.nih.gov]

He had a past history of chronic pityriasis lichenoides, and serum antinuclear antibody was positive. [ncbi.nlm.nih.gov]

Juvenile Idiopathic Arthritis

- systemic JRA : begins w/ high spiking fevers ( > 39.3) & rash; - Labs: - synovial fluid exam : - antinuclear antibody test : - positive antinuclear antibody test is diagnostic [wheelessonline.com]

However, many children with JIA do not have rheumatoid factor or antinuclear antibodies in their blood. [msdmanuals.com]

Children with JIA who have antinuclear antibodies in their blood are at a higher risk of developing iridocyclitis. [msdmanuals.com]

Polyarticular Juvenile Idiopathic Arthritis

Involvement of the small or upper extremity joints at disease diagnosis and MTX initiation was more frequent; antinuclear antibody (ANA) positivity was less frequent; acute [ncbi.nlm.nih.gov]

*The incidence of anterior uveitis increases when antinuclear antibodies (ANA) are present. [amboss.com]

One of the blood tests taken may show a positive result for antinuclear antibodies. Antinuclear antibodies are a type of protein in the blood, called auto-antibodies. [patient.info]

Connective Tissue Disease

[…] for the presence of antinuclear antibodies (ANA) and for cyclic citrullinated peptide (CCP) antibodies. [mayocliniclabs.com]

We describe a 28-year-old man with linear atrophoderma of Moulin (LAM), whose serum immunological markers were abnormal (including antinuclear antibody, ribonucleoprotein, [ncbi.nlm.nih.gov]

Despite arthritis and myositis that required treatment, low level C3 and C4, positive antinuclear antibodies, and elevated anticardiolipin antibodies only once, in a follow-up [ncbi.nlm.nih.gov]

Oligoarthritis

ANA: antinuclear antibody. Figure 5. [jrheum.org]

Retrospective assessments included sex, onset age, disease duration, antinuclear antibodies, HLA-B27, uveitis, ocular complications, second-line therapies, intraarticular [ncbi.nlm.nih.gov]

Risk factors included sex, age at arthritis onset, disease category, and antinuclear antibody (ANA) status. [ncbi.nlm.nih.gov]

Lupus Erythematosus

Abbreviations: ACLA : anticardiolipin antibody ANA : antinuclear antibody APLS : antiphospholipid antibody syndrome ARF : acute rheumatic fever DIL : drug-induced lupus dsDNA [pedsinreview.aappublications.org]

American College of Rheumatology: "Antinuclear Antibodies (ANA)." [webmd.com]

Understand the meaning of a positive antinuclear antibody. Understand the serologic markers associated with SLE. [pedsinreview.aappublications.org]

Systemic Lupus Erythematosus

The only proof to support the SLE is that we observed a weakly positive antinuclear antibody (ANA) in serum at the onset. [ncbi.nlm.nih.gov]

(2) any other autoimmune connective tissue disease, and/or (3) antinuclear antibodies >1/320. [ncbi.nlm.nih.gov]

Systemic Lupus Erythematosus with Organ/System Involvement

These antibodies are mostly antinuclear antibodies (ANA) that react with the body's own DNA leading to the formation of immune complexes that deposit on blood vessel walls [ypo.education]

Nearly all people with lupus have a positive test for antinuclear antibody (ANA). However, having a positive ANA alone does not mean you have lupus. [medlineplus.gov]

Systemic Scleroderma

Antinuclear antibody titer and pattern were measured by indirect immunofluorescence with human epithelial (HEp)-2 cells and tissue sections, whereas anti-Scl-70 antibodies [ncbi.nlm.nih.gov]

RESULTS: Antinuclear antibodies (ANA) were detected in 94.2% of patients. [ncbi.nlm.nih.gov]

While hypercoagulability including positive anticardiolipin antibodies was found in only 1 patient, all patients were antinuclear antibody (ANA) positive and 6 of 8 patients [ncbi.nlm.nih.gov]

Psoriatic Juvenile Idiopathic Arthritis

antibodies. [ncbi.nlm.nih.gov]

Early-onset disease is characterized by female predominance, small joint involvement, dactylitis, and positive antinuclear antibodies. [ncbi.nlm.nih.gov]

[…] no difference in the percentage of patients between the oligoarticular groups who developed extended oligoarthritis or in the percentage of patients who were positive for antinuclear [ncbi.nlm.nih.gov]

Diffuse Cutaneous Systemic Scleroderma

Thus, the severity of organ manifestations varied not only with the form of PSS, but also with the absence/presence of antinuclear antibody. [ncbi.nlm.nih.gov]

In contrast to SSc, Raynaud's phenomenon and cutaneous calcinosis were absent and antinuclear antibodies were negative. [ncbi.nlm.nih.gov]

Sixty eight per cent of the patients with diffuse scleroderma and 62% of those with the CREST syndrome had a positive antinuclear antibody test, which was associated with [ncbi.nlm.nih.gov]

Sjögren Syndrome

Serum antinuclear antibodies (ANA) were elevated (1 : 320). [ncbi.nlm.nih.gov]

The distinction between fibromyalgia patients with low titer antinuclear antibodies and primary SS remains difficult. [ncbi.nlm.nih.gov]

The problems of diagnosis are further compounded by the finding of “positive” antinuclear antibodies in a high percent of the general population. [doi.org]

Insulin-Resistance Syndrome Type B

antibodies or decreased levels of certain complement factors). [rarediseases.info.nih.gov]

Mixed connective tissue disease was diagnosed with high titers of antinuclear antibody, ribonucleoprotein antibody and interstitial lung disease. [ingentaconnect.com]

[…] well-characterized autoimmune disease (systemic lupus erythematosus; see this term), or suggest an immune disease (such as an elevated sedimentation rate, proteinuria, high levels of antinuclear [rarediseases.info.nih.gov]

Drug-Induced Lupus Erythematosus

The antinuclear antibody and antihistone antibody were positive. [doi.org]

[…] who were symptomatic from a drug-induced lupus-like illness (DILE) and asymptomatic patients who had drug-induced antinuclear antibodies (DANA). [ncbi.nlm.nih.gov]

Monocytes, one type of white blood cell, detect the antigen and relay the recognition to T helper cells, creating antinuclear antibodies leading to an immune response. [en.wikipedia.org]

Lupus Encephalitis

It has also been found that ultraviolet light can lead to the formation of antinuclear antibodies. [ncbi.nlm.nih.gov]

Additional tests were positive for antinuclear antibodies (ANA) and anti-DNA antibodies, elevated myoglobin, and low complement 3 and 4. [healio.com]

Serological tests for lupus antibodies include antinuclear antibodies (ANA), antiphospholipid antibodies, and anticardiolipin antibodies will be positive in patients with [symptoma.com]

Localized Scleroderma

Laboratory testing was positive for antinuclear antibody and a high serum creatine kinase level. [ncbi.nlm.nih.gov]

METHODS: In 90 morphea patients the presence of Borrelia-specific serum antibodies was correlated to the age at disease onset and the presence and titers of antinuclear antibodies [lookingatlyme.blogspot.com]

Further work-up revealed a negative antinuclear antibody, anti-double-stranded DNA, anti-Scl-70, and anti-centromere. Borrelia titers were not obtained. [ncbi.nlm.nih.gov]

Polyarthritis

Rheumatoid factor, anticyclic citrullinated protein antibody, antinuclear antibodies, anti-Borrelia, and burgdorferi antibodies were all negative, and myoglobin and calcitonin [ncbi.nlm.nih.gov]

Laboratory Tests ANTINUCLEAR ANTIBODY SLE without antinuclear antibodies comprises less than 2% of cases; therefore, SLE is unlikely in a patient with polyarthritis who tests [aafp.org]

The antinuclear antibody test was negative and MRI results revealed mild cervical intervertebral disk disease (IVDD). [dbpia.co.kr]

Idiosyncratic Drug-Induced Liver Injury

Hepatitis B surface antigen, hepatitis C virus antibody, antinuclear antibody, and antimitochondrial antibody were undetectable. [care.diabetesjournals.org]

Investigations may also need to include an assessment for other causes of hepatitis and may include hepatitis viral serology, antinuclear antibodies, copper and iron levels [patient.info]

C-reactive protein Consider NSAIDs, antihistamines, or systemic corticosteroids; or plasmapheresis if severe. 18 Immune complexes Complement studies Antinuclear antibody, [aafp.org]

Juvenile Seronegative Polyarthritis

Labs (often non-diagnostic) Precautions Rheumatoid Factor and Antinuclear Antibody are negative in more than 80% of juvenile RA Rheumatoid Factor Variably positive, often [fpnotebook.com]

Laboratory tests such as ESR, rheumatoid factor ( RF ), antinuclear antibodies ( ANA ), and the HLA-B27 antigen test are used to classify and determine the prognosis of JIA [amboss.com]

The antinuclear antibody (ANA) test can be of value when clinical findings strongly suggest JRA. [news-medical.net]

Autoimmune Hepatitis

She was positive for antinuclear antibody, double stranded DNA antibody and LKM 1 antibody. [ncbi.nlm.nih.gov]

Blood tests showed high levels of liver enzymes, IgG, IgG4, and antinuclear antibody. [ncbi.nlm.nih.gov]

Characterised by the presence of circulating auto-antibodies (antinuclear antibody, smooth muscle antibody, perinuclear anti-neutrophil cytoplasmic auto-antibody, anti-soluble [bestpractice.bmj.com]

Primary Biliary Cirrhosis

Moreover, several types of antinuclear antibodies have been associated with primary biliary cirrhosis. [ncbi.nlm.nih.gov]

Antibodies against mitochondria are characteristic of PBC and found in about 90% of patients. About 50% of patients with PBC also have antinuclear antibodies. [texasliver.com]

Found in 25% of patients, these antinuclear antibodies must be sought before a strong suspicion of primary biliary cirrhosis with antimitochondrial antibodies negative, as [ncbi.nlm.nih.gov]

Libman-Sacks Disease

antibody. [annalspc.com]

Recognize why antinuclear antibody testing lacks specificity. Know the specific serologic markers for SLE. Discuss the treatment for SLE. [pedsinreview.aappublications.org]

antibody titer. [annalspc.com]

Systemic Juvenile Idiopathic Arthritis

Autoimmune and infective serological tests (eg, viral hepatitis tests, anti-immunodeficiency virus antibody, antinuclear antibody rheumatoid factor and mononuclesosis antibodies [scielo.br]

Results of antinuclear antibody, ANCA, rheumatoid factor, and anti-cyclic citrullinated peptide tests were also negative. [medscape.com]

Labs (often non-diagnostic) Precautions Rheumatoid Factor and Antinuclear Antibody are negative in more than 80% of juvenile RA Rheumatoid Factor Variably positive, often [fpnotebook.com]

Lupus Nephritis

Literature review on antinuclear antibody (ANA)-negative and seronegative LN revealed the following patient presentations: (1) renal-limited or renal and extra-renal manifestations [ncbi.nlm.nih.gov]

This study aimed to determine the clinical manifestations and Antinuclear Antibodies (ANA) profile among Sudanese adults with SLE and lupus nephritis (LN). [ncbi.nlm.nih.gov]

Malleson PN, Sailer M, Mackinnon MJ: Usefulness of antinuclear antibody testing to screen for rheumatic diseases. [karger.com]

Overlap Syndrome

Hematology revealed elevated levels of hepatobiliary enzymes and positive results for antinuclear antibody (ANA) and antimitochondrial (AMA) M2 antibody. [ncbi.nlm.nih.gov]

Autoimmune hepatitis also known as Lupoid hepatitis is an autoimmune liver disease characterized by the presence of autoantibodies including antinuclear antibodies (ANA) and [ncbi.nlm.nih.gov]

Diagnostic work-up was remarkable for a positive antinuclear antibodies (ANA) test and a liver biopsy suggestive of an AIH-PBC overlap syndrome. [ncbi.nlm.nih.gov]