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12 Possible Causes for Antinuclear Autoantibodies, Degeneration of Epidermal Basal Cells

  • Systemic Lupus Erythematosus

    Systemic lupus erythematosus is characterised by the presence of antinuclear autoantibodies (ANA).[hungary.pure.elsevier.com] […] of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with[medical-dictionary.thefreedictionary.com] […] for antinuclear antibodies.[ncbi.nlm.nih.gov]

  • Discoid Lupus Erythematosus

    Wallace ; Antinuclear autoantibodies in cutaneous lupus erythematosus: biochemical and cell biological characterization of Ro/SSA / Anna von Mikecz -- Part I: Introduction[worldcat.org] […] hydropic degeneration of the basal cell layer, thickening of the basement membrane zone, telangiectasia, superficial and deep perivascular and periadnexal lymphocytic inflammatory[scielo.br] Routine laboratory tests were normal, tests for autoantibodies (antinuclear antibody, extractable nuclear antigen, and anti-Ro/ SSA and anti-La/SSB) were negative and immunohistochemistry[scielo.br]

  • Lupus Erythematosus

    Presence of antinuclear antibodies. Certain autoantibodies (anti-dsDNA and anti-Sm) have great specificity for the diagnosis of SLE, but lack sensitivity.[accessmedicine.mhmedical.com] […] of basal cells; 4) a predominantly lymphocytic infiltrate along the dermal-epidermal junction, around the fair follicles and eccrine ducts, in an interstitial pattern; 14[scielo.br] (2) 98% of SLE patients have antinuclear antibodies (ANA) but are non-specific anti-double-stranded DNA (dsDNA) seen in around 70% of cases is highly specific for SLE other[gpnotebook.co.uk]

  • Cutaneous Lupus Erythematosus

    Wallace ; Antinuclear autoantibodies in cutaneous lupus erythematosus: biochemical and cell biological characterization of Ro/SSA / Anna von Mikecz -- Part I: Introduction[worldcat.org] […] of basal cells; 4) a predominantly lymphocytic infiltrate along the dermal-epidermal junction, around the fair follicles and eccrine ducts, in an interstitial pattern; 14[scielo.br] Subacute cutaneous lupus erythematosus occurs in genetically predisposed individuals, most often in patients with the anti-Ro (SS-A) autoantibody, a positive antinuclear antibody[aocd.org]

  • Vasculitis

    […] antibodies, anti-DNA, anti-Ro, and anti-La antibodies, cryoglobulins, anticardiolipin, and antineutrophil cytoplasmic autoantibodies (ANCA) (indirect immunofluorescence test[jamanetwork.com] There is sparse scattered lymphocytic infiltration centred around the basal layer /- vacuolar degeneration of the basal layer.[dermnetnz.org] IgG vs Neutrophil Cytoplasmic Antigens Wegener's Granulomatosis or Polyarteritis Nodosa Antinuclear antibodies Serum M-Protein: Rare Pathology Biopsy necessary for diagnosis[neuromuscular.wustl.edu]

  • Lichen Sclerosus

    Autoantibodies 316 Not always reported or sought. Thyroid antimicrosomal, gastric parietal cell, and antinuclear autobodies most common.[cirp.org] […] with hydropic degeneration of basal cell, flattening of rete ridges, pronounced edema, and homogenization of collagen in upper dermis with lymphocytic infiltrate in mid-dermis[ncbi.nlm.nih.gov] […] have been reported to be more common in patients with LS, including thyroid antimicrosomal, antigastric parietal cell, and antinuclear antibodies. 250, 255, 263 Anti-adrenal[cirp.org]

  • Actinic Lichen Planus

    Autoantibodies 316 Not always reported or sought. Thyroid antimicrosomal, gastric parietal cell, and antinuclear autobodies most common.[cirp.org] Histology classically demonstrates hyperkeratosis, epidermal thinning, vacuolar degeneration of the basal cell layer, lymphohistiocytic band-like infiltrate, variable Civatte[jcadonline.com] […] of the basal cell layer with pigment incontinence and keratinocyte apoptosis.[e-ijd.org]

  • Chilblain Lupus Erythematosus

    Patients with SLE can have a wide variety of autoantibodies against nuclear and cytoplasmic cellular components.[medical-dictionary.thefreedictionary.com] In particular, skin histopathology of DLE shows classical features: vacuolar degeneration of basal cell layer; thickened basement membrane; orthokeratosis with follicular[ped-rheum.biomedcentral.com] The presence of high levels of antinuclear antibody (ANA) in SLE patients with glomerulonephritis indicates a pathogenic role for that antibody.[medical-dictionary.thefreedictionary.com]

  • Dyschromatosis symmetrica hereditaria

    Recommended laboratory tests include a complete blood count; sedimentation rate; comprehensive metabolic panel, including liver function tests; and autoantibody tests (antinuclear[what-when-how.com] Light microscopy and ultrastructural studies have also revealed vac-uolar degeneration of basal and parabasal keratinocytes and revealed epidermal and dermal lymphohistiocytic[what-when-how.com] Antithyroid, gastric antiparietal cell, and antinuclear antibodies are most commonly demonstrated.[what-when-how.com]

  • Bullous Systemic Lupus Erythematosus

    The most common type of autoantibody that develops in people with lupus is called an antinuclear antibody (ANA) because it reacts with parts of the cell's nucleus (command[webmd.com] […] of the epidermal basal layer.[mussenhealth.us] For example, antinuclear antibodies (ANAs) are detected in almost all affected individuals.[emedicine.medscape.com]

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