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17 Possible Causes for Apathy, Cardiac Arrhythmia, Persistent Lactic Acidosis

  • Cardiogenic Shock

    lactic acidosis, low cardiac output, high doses of catecholamines, kidney and/or liver failure) and of cardiac arrest without “no flow” in patients with advanced chronic[] Carditis can complicate Lyme disease in an estimated 5% of cases, and cardiogenic shock and severe cardiac arrhythmias are described with electrocardiographic abnormalities[] The occurrence of serious cardiac arrhythmias is rare in lithium intoxication.[]

  • Hypoglycemia

    Feeling of numbness, pins and needles (paresthesia) Negativism, irritability, belligerence, combativeness, rage Personality change, emotional lability Fatigue, weakness, apathy[] Nocturnal hypoglycemia has been associated with cardiac arrhythmias resulting in sudden death[ 73 ].[] In AN various cardiac complications may occur: hypotension, bradycardia, life-threatening ventricular arrhythmias, pericardial effusion, reduction of left ventricular mass[]

  • Acidosis

    Neurological: “hypercapnic encephalopathy”include 1. irritability, inability to concentrate, 2. headache, anorexia, 3. apathy, confusion, combativeness, hallucinations, delirium[] Hyperlactatemia is defined as a persistent, mild to moderate (2-4 mmol/L) increase in blood lactate concentration without metabolic acidosis , whereas lactic acidosis is characterized[] In mild cases the symptoms may be overlooked; in severe cases symptoms are more obvious and may include muscle twitching, involuntary movement, cardiac arrhythmias, disorientation[]

  • MELAS Syndrome

    Weakness, lethargy, and apathy are common. Many of the symptoms result from stroke-like episodes.[] MELAS syndrome was suspected postoperatively owing to persistent lactic acidosis and neurological symptoms.[] The recently published report, titled “Arrhythmia as a cardiac manifestation in MELAS syndrome” appeared in the journal Molecular Genetics and Metabolism Reports .[]

  • Lactic Acidosis

    As such, the concept of a lactic acidosis remains evidence of 1920s academic and scientific inertia that, out of simple convenience and apathy, still remains today.[] […] interval: 2.5-20.6; P CONCLUSION: In the absence of risk factors associated with persistent lactic acidosis, such as shock or acute kidney or liver injury, continued peri-operative[] In mild cases the symptoms may be overlooked; in severe cases symptoms are more obvious and may include muscle twitching, involuntary movement, cardiac arrhythmias, disorientation[]

  • Spastic Quadriplegic Cerebral Palsy Type 2

    Leukoencephalopathy Cerebral cortical atrophy Developmental regression Sensorineural hearing impairment Hearing impairment Coma Hallucinations Hypoglycemia Absent speech Apathy[] In addition, patients do not develop severe metabolic crises in the neonatal period as observed in other organic acidurias, but may show persistent lactic acidosis, most likely[] ARRHYTHMIAS, AND NEURODEGENERATION; MECRCN Recurrent metabolic encephalomyopathic crises-rhabdomyolysis-cardiac arrhythmia-intellectual disability syndrome is a rare, genetic[]

  • Leigh's Disease

    Four of the 15 had some form of mental retardation such as loss of speech, progressive apathy, lethargy or frank dementia.[] All children developed progressive neurological deterioration and persistent metabolic lactic acidosis, which was treated with sodium bicarbonate, and the 1st patient needed[] Symptoms – Infantile: Reye-like syndrome, enlarged liver, hypoglycemia, enlarged heart, and cardiac arrhythmia. Causes: Autosomal recessive.[]

  • Septic Shock

    . – Consciousness usually maintained, but anxiety, confusion, agitation or apathy are common. – Oliguria or anuria.[] acidosis, persistent, oliguria, low BP and a narrow PP, tachycardia, and skin/extremity findings of low flow.[] We also found a statistically significant decrease in the rate of cardiac arrhythmias in the norepinephine group as compared to the dopamine group: pooled RR: 0.43 (95% CI[]

  • Congenital Intrinsic Factor Deficiency

    Our patient also showed classical neurological symptoms of B12 deficiency: irritability, failure to thrive, apathy, anorexia and developmental regression. 7 Causes of the[] PO2 will typically be low, and if this condition persists, there will be progression to metabolic acidosis with accumulation of lactic acid.[] Other uncommon side effects include skin rash, hot flushes, nausea, dizziness and cardiac arrhythmias.[]

  • Episodic Mitochondrial Myopathy - Optic Atrophy - Reversible Leukoencephalopathy

    Weakness, lethargy, and apathy may be present early.[] Patient 2 was born prematurely and had persistent, severe lactic acidosis from birth on.[] arrhythmias.[]

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