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27 Possible Causes for Apathy, Green Jaundice, Iron Increased

  • Hemochromatosis

    General symptoms comprise chronic fatigue, weakness, lethargy, and apathy.[emedicine.com] […] or odd colored skin (ashen gray green or reddish) • Abdominal pain (upper right quadrant—in area of the liver) • Joint pain • Rapid weight loss • Gall bladder, pancreas or[irondisorders.org] Recent studies have shown an increased concentration of redox-active iron in plasma in patients with increased transferrin saturation.[ncbi.nlm.nih.gov]

  • Portal Cirrhosis

    Psychometric tests normal Stage I Mild lack of awareness Attention span is shortened Impaired ability to add and subtract Asterixis is possible EEG : triphasic waves Stage II Apathy[amboss.com] Kayser-Fleischer ring—brown-green ring of copper deposit around the cornea, pathognomonic for Wilson’s disease Nail changes: Muehrcke’s nails—paired horizontal white bands[aafp.org] Clinical manifestations Disturbances of consciousness, ranging from mild confusion to coma Multiple neurological and psychiatric disturbances like: Asterixis Fatigue, lethargy, apathy[amboss.com]

  • Liver Failure

    Kayser-Fleischer ring—brown-green ring of copper deposit around the cornea, pathognomonic for Wilson’s disease Nail changes: Muehrcke’s nails—paired horizontal white bands[aafp.org] Serum ferritin levels are frequently elevated, while iron and iron-binding capacity are normal ( 42 , 130 ).[care.diabetesjournals.org] Iron accumulation, which is a common finding in advanced ALD, has also been associated with hepatic fibrosis in ALD and increased mortality in alcoholic cirrhosis ( 18,19[gi.org]

  • Primary Hemochromatosis Type 1

    Clinical Symptoms and Physical Manifestations in Patients with Hereditary Hemochromatosis Abdominal pain Amenorrhea Apathy Arthralgias Ascites Cardiomyopathy Cirrhosis Congestive[aafp.org] […] or odd colored skin (ashen gray green or reddish) • Abdominal pain (upper right quadrant—in area of the liver) • Joint pain • Rapid weight loss • Gall bladder, pancreas or[irondisorders.org] It is believed that encoding hepcidin in liver iron increases when blood enters liver cells.[ivami.com]

  • Hereditary North American Indian Childhood Cirrhosis

    Neurologic manifestations  Changes in consciousness include hypersomnia, reversal of sleep pattern, apathy, slowed speech, decreased spontaneous movement, and eventually[slideshare.net] Hepatoencephalopathy due to combined oxidative phosphorylation defect type 1 Hepatoportal sclerosis Hereditary North American Indian childhood cirrhosis Hereditary fructose intolerance Hyperbiliverdinemia[se-atlas.de] […] of transferrin-bound iron.[doi.org]

  • Neonatal Jaundice

    Other symptoms which should be reported to the pediatrician are disinterest in eating, general apathy, breathing difficulties, or temperature instability.[childbirthsolutions.com] Paediatrics 27 Jun, 2017 0 Patrick Green Introduction Neonatal Jaundice is very common, with 60% of babies being jaundiced at some point.[almostadoctor.co.uk] Abstract Cleavage of the alpha-methene bridge of heme by membrane-bound heme oxygenase yields equimolar amounts of biliverdin, carbon monoxide, and reduced iron.[neoreviews.aappublications.org]

  • Cyanotic Congenital Heart Disease

    Parents should be alarmed by unsatisfactory ponderal gain, cyanosis (permanent or due to the effort of feeding), profuse perspiration, apathy, fast or difficult breathing,[symptoma.com] In these patients, the coincidence of cyanosis and jaundice caused an atypical green-appearing cutaneous discoloration which masked the early clinical detection of biliary[ncbi.nlm.nih.gov] Average Hb and Hct values following 3-month iron treatment increased from 14.8   2.4 g/dl to 16.0   2.0 (P   0.003) and from %45.8   7.5 to %47.6   7.2 (P   0.052), respectively[ncbi.nlm.nih.gov]

  • Chronic Liver Disease

    […] being the West Haven Criteria ( Ferenci et al, 2002 ). trivial lack of awareness; euphoria or anxiety; shortened attention span; impaired performance on basic math lethargy, apathy[sharinginhealth.com] Kayser-Fleischer ring—brown-green ring of copper deposit around the cornea, pathognomonic for Wilson’s disease Nail changes: Muehrcke’s nails—paired horizontal white bands[aafp.org] G&H Does iron overload increase the risk of liver cancer?[gastroenterologyandhepatology.net]

  • Thallium Poisoning

    […] irritability, nausea, vomiting, diarrhoea, swollen abdomen, cellulite, low blood pressure resulting from an imbalance of potassium to sodium ratio, confusion and mental apathy[naturalhealthgroup.com.au] Urine may have a slight green discoloration. Hepatic failure or jaundice occurs in extreme cases.[calpoison.org] Results of the biochemical analysis showed affects on the liver in the form of increased alkaline phosphatase.[oem.bmj.com]

  • Hereditary Hyperekplexia

    […] leukoencephalopathy with axonal spheroids and pigmented glia is a rare autosomal dominant disease characterized by a complex phenotype including progressive dementia, apraxia, apathy[amp.pharm.mssm.edu] Joubert syndrome 17 Cardiac conduction defect, nonspecific Lethal multiple pterygium syndrome Non-small cell lung cancer Acroerythrokeratoderma Renal hypodysplasia/aplasia 2 Hyperbiliverdinemia[amp.pharm.mssm.edu] […] accumulation (NBIA; see this term) characterized by psychomotor delay and regression, increasing neurological involvement with symmetrical pyramidal tract signs and spastic[amp.pharm.mssm.edu]

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