Apathy & Progressive Memory Impairment: Causes & Reasons

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Patient File

Sex unknown, Age unknown

Reported Symptoms

Apathy, Progressive Memory Impairment,

Negated

None

Unsure

None

Possible Causes

Alzheimer Disease

Apathy represents a form of executive cognitive dysfunction. [ncbi.nlm.nih.gov]

The proband presented at age 42 years with a 3-year history of progressive short-term memory impairment and depression. [ncbi.nlm.nih.gov]

Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment of memory and other cognitive functions. [ncbi.nlm.nih.gov]

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Alcohol Dementia

ARD patients often have symptoms of both forms, i.e. impaired ability to plan, apathy, and memory loss. ARD may occur with other forms of dementia (mixed dementia). [en.wikipedia.org]

Allowing someone with Alzheimer’s to drink too much can cause further memory impairment and speed up the progression of their disease. [carefecthomecareservices.com]

Researchers have also reported that imbibing a daily glass or wine or other alcoholic drink may slow the progression to Alzheimer’s in people with mild cognitive impairment [alzinfo.org]

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Brain Concussion

Stern listed symptoms of CTE: "Changes in mood, like depression and apathy. "Changes in behavior — such as impulse control problems, rage and aggression. [nbcnews.com]

CTE is marked by "memory loss, confusion, impaired judgment, impulse control problems, aggression, depression, and, eventually, progressive dementia," according to Boston [rt.com]

The symptoms of CTE may include memory loss, confusion, impaired judgment, impulse control problems, aggression, depression, anxiety, suicidality, parkinsonism (movement symptoms [alz.org]

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Dementia

Apathy, depression, irritability, agitation, and anxiety are the most frequently detected neuropsychiatric symptoms of AD. [ncbi.nlm.nih.gov]

As dementia progresses, memory loss and cognitive impairment broaden in scope until the individual can no longer remember basic social and survival skills or function independently [britannica.com]

A 42-year-old woman presented with a 6-month history of diffuse headache of moderate intensity and gradual onset of generalized weakness, imbalance, apathy, memory decline [ncbi.nlm.nih.gov]

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Binswanger Disease

Patients with this disease usually present with apathy, agitation, and bilateral corticospinal or bulbar signs Tags: binswanger', s-disease, subcortical-dementia, white-matter-atrophy [medicalvideos.com]

memory impairment, mild mental disorder, personality changes (apathy, delusions), mental depression, slurred speech, a simple calculation error, the answer to my question [e.uuuwell.com]

[…] the forgetfulness of Alzheimer's disease), changes in speech, an unsteady gait, clumsiness or frequent falls, changes in personality or mood (most likely in the form of apathy [ninds.nih.gov]

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Normal Pressure Hydrocephalus

Among 46 patients with suspicion of iNPH (77.6 6.7years; 34.8% women), 30 (65.2%) presented apathy (defined by a score 14 on the Starkstein apathy scale). [ncbi.nlm.nih.gov]

We report the case of a 39-year-old white woman with systemic lupus erythematosus who developed magnetic gait, speech difficulties, progressive memory impairment, urinary [ncbi.nlm.nih.gov]

The thinking difficulties can eventually progress into a dementia. [medfriendly.com]

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Parkinson Disease

Apathy was identified in 31.6%; apathy without depression was present in 33.3% of patients. [ncbi.nlm.nih.gov]

Cognitive impairment affecting executive functions such as attention, recognition, working memory, and problem solving may also appear in the pre-motor phase and progressively [biolegend.com]

[…] neurologic disease that results in the irreversible loss of neurons, particularly in the cortex and hippocampus. 5 The clinical hallmarks are progressive impairment in memory [doi.org]

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Organic Personality Disorder

emotional instability, marked apathy, or impaired impulse control, caused by a specific organic factor and not associated with delirium, prominent mood disturbance, delusions [medical-dictionary.thefreedictionary.com]

Course, prognosis & treatment• Slowly progress memory impairment• Aphasia, apraxia and agnosia also present• May later develop motor & gait disturbances;may become bedridden [slideshare.net]

The symptoms of apathy and irritability are common between these two groups of patients. [en.wikipedia.org]

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Multi-Infarct Dementia

[…] include: Forgetfulness (but not as severe as Alzheimer's disease) Urinary incontinence Difficulty walking Clumsiness Changes in personality or mood (most likely in the form of apathy [alzheimers.emedtv.com]

During the 2 years before admission, he had suffered from insomnia, depressed mood and progressive memory disturbance. [ncbi.nlm.nih.gov]

Psychiatric disorders are also common and include depression, apathy and personality changes. [orpha.net]

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Bipolar Disorder

Some symptoms of OSA are the same as the symptoms of depression: daytime drowsiness, cognitive dysfunction, decreased drive, apathy, depressed mood, anhedonia. [ncbi.nlm.nih.gov]

[…] and its progression. [doi.org]

[…] experienced on most days: depressed mood loss of interest or pleasure in activities that used to be enjoyable weight loss or gain difficulty sleeping or sleeping too much apathy [camh.ca]

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Kluver-Bucy Syndrome

A 70-year-old man with progressive behavioral symptoms of hyperorality, hypersexuality, hypermetamorphosis, visual agnosia, hyperphagia, and apathy who died at age 77 of asphyxiation [ncbi.nlm.nih.gov]

[…] significantly decreased her ability to make new declarative memories and maintain adequate academic progress. [ncbi.nlm.nih.gov]

A couple days after admission, our patient became alert and presented hypersexuality, hypermetamorphosis, increased oral tendency, behavior changes including apathy with loss [ncbi.nlm.nih.gov]

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Boxer's Dementia

Emotional symptoms that can follow TBI include emotional instability, depression, anxiety, hypomania, mania, apathy, irritability, and anger. [en.wikipedia.org]

REUTERS/Ajay Verma CTE is common in ex-boxers and has been linked to progressive memory, behavioral and motor impairment. [reuters.com]

Patients may show extreme behavioral changes such as inappropriate actions, loss of empathy, lack of judgement, apathy, repetitive compulsive behavior, decline in personal [onhealth.com]

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Organic Brain Syndrome

Progression of Dementia Phase 1 Forgetfulness: progressive memory impairment Recent and short term memory effected Deficits in attention, orientation, and concentration Will [quizlet.com]

[…] age, characterized by early, slowly progressing changes of character and social deterioration, followed by impairment of intellect, memory, and language functions, with apathy [apps.who.int]

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Frontal Lobe Neoplasm

Personality and abrupt emotional changes (aggression, apathy, impulsive behavior), and an overall decline of the functions for which the frontal lobe is crucial - planning [symptoma.com]

Although radiation therapy may lead to longer survival, the side effects of radiation, such as impaired thinking and memory, limit its practical use in people with these tumors [aans.org]

[…] arising the meningeal layer between the hemispheres of the brain) Common Symptoms - Seizures, lower extremity weakness, headache, personality changes, dementia, increasing apathy [neurosurgery.ucla.edu]

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Huntington Disease

Apathy severity increases in the motormanifest stages of Huntington's disease. HDGECs can adequately assess their level of apathy on a self-report questionnaire. [ncbi.nlm.nih.gov]

Impaired memory and cognition: Progressive loss of memory is a key feature of Huntington’s disease. Initially, there is a loss of short-term memory. [symptoma.com]

As the disease progresses, the ability to speak may be impaired, memory may fade, and the involuntary jerky muscle movements (chorea) become more severe. [rarediseases.org]

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Encephalopathy

PATIENT CONCERNS: We presented a case of a 63-year-old female patient with paroxysmal dizziness, unsteady gait, emotion apathy, progressive cognitive impairment, and unusual [ncbi.nlm.nih.gov]

Symptoms An altered mental state may include: Sudden or progressive changes in memory Inability to concentrate Impaired thinking Abnormal drowsiness Mood changes Progressive [winchesterhospital.org]

[…] occur in many other conditions, but in the few people with proven CTE, symptoms have included: Difficulty thinking (cognitive impairment) Impulsive behavior Depression or apathy [mayoclinic.org]

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Carbon Monoxide Poisoning

Both patients demonstrated cognitive impairment, apathy, and hypokinesia on admission. [ncbi.nlm.nih.gov]

On the 27th day of exposure, the patient developed disorientation and memory impairment. [ncbi.nlm.nih.gov]

This late stage is more common in those aged over 40. [ 3 ] Neurological or neuropsychiatric features including disorientation, apathy, mutism, irritability, inability to [patient.info]

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Pernicious Anemia

As the disease progresses, muscle spasms and problems with balance and walking may develop. Memory impairment, tremors, confusion, depression or paranoia may also occur. [livehealthy.chron.com]

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Frontotemporal Dementia

[…] and disinhibition; PSA primary severe apathy; SA D severe apathy and disinhibition. [n.neurology.org]

The second patient presented with progressive memory impairment and marked personality changes after a transient ischaemic attack. [ncbi.nlm.nih.gov]

雑誌名 Psychogeriatrics 11 ページ : 46-53 関連する報告書査読あり [雑誌論文] Risk of progression from mild memory impairment to clinically diagnosable Alzheimer disease in a Japanese community [kaken.nii.ac.jp]

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CADASIL Syndrome

Psychiatric disorders are also common and include depression, apathy and personality changes. [orpha.net]

She later developed progressive memory impairment and gait ataxia. She has a family history of hearing loss, migraine, early-onset dementia and gait imbalance. [neurology.org]

Migraine headaches are an early symptom of this condition, which progresses to strokes and mini-strokes, depression, apathy, motor disability and excutive dysfunction (an [corleycadasil.btck.co.uk]

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Kleine-Levin Syndrome

Defects in the dorsomedial prefrontal cortex may cause apathy. [ncbi.nlm.nih.gov]

Memory impairments may persist after an episode ... I think this is true with Jake, so is something to be aware of... [kleinelevinsyndrome.co.uk]

[…] characterized by episodes lasting from 1 to several weeks, and comprises neurological (hypersomnia, confusion, slowness, amnesia) and neuropsychiatric symptoms (derealization and apathy [ncbi.nlm.nih.gov]

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Creutzfeldt Jakob Disease

Whether symptoms develop gradually or abruptly, mental decline progresses, often producing such symptoms as neglect of personal hygiene, apathy, and irritability. [web.archive.org]

Mild cognitive impairment Creutzfeldt-Jakob disease : A rare progressive brain disorder. Dementia : General memory loss. [uhhospitals.org]

Clinical features Early in the illness, patients usually experience psychiatric or sensory symptoms, which most commonly take the form of depression, apathy or anxiety, and [web.archive.org]

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Toxic Encephalopathy

Fluctuations of alertness and attention; Decreased concentration and coherent thought/skilled movements; Disorientation, memory, language, irritability and agitation, restlessness, apathy [quizlet.com]

The patient and his family noticed impaired short-term memory function and changes in affect in his early forties, which progressed until after he stopped working and was [ncbi.nlm.nih.gov]

Wernicke's encephalopathy a neurological disorder characterized by confusion, apathy, drowsiness, ataxia of gait, nystagmus, and ophthalmoplegia; it is due to thiamine deficiency [medical-dictionary.thefreedictionary.com]

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Neurological Disorder

Symptoms of Degenerative Diseases: Anxiety Apathy Agitation Inhibition loss Memory loss Forgetfulness Constant mood changes Brain injuries Many cases of a neurological disorder [vinnhospital.com]

Again, this disease is progressive, impairs memory and behaviour and is the sixth leading cause of death in America with no cure in sight so far. [blog.thryveinside.com]

FvFTD, exemplified here, often presents first to a psychiatrist, typically with a blunting of emotions, apathy, and egocentricity. [jnnp.bmj.com]

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Progressive Supranuclear Palsy

RESULTS: The three groups differed significantly at the Apathy Rating Scale score and at several neuropsychological domains. [ncbi.nlm.nih.gov]

Abstract Cognitive impairment is integral to the syndrome of progressive supranuclear palsy. [ncbi.nlm.nih.gov]

Behavioral changes, such as depression, anxiety, apathy, and irritability, were reported. [ncbi.nlm.nih.gov]

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Classic Progressive Supranuclear Palsy Syndrome

[…] resting tremo -swallowing difficulties -postural instabillity with falling down (backwards) -Downward gaze abnormalities -forgetfulness -bradyphrenia -personality changes like apathy [quizlet.com]

Memory impairment in patients with progressive supranuclear palsy. Arch Neurol. 1989;46(7):765–767. 49. Dubois B, Pillon B, Legault F, Agid Y, Lhermitte F. [dovepress.com]

Affected individuals often show alterations of mood and behavior, including depression and apathy as well as progressive mild dementia. [primumn0nn0cere.wordpress.com]

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Herpes Simplex Encephalitis

Profound neurological symptomatology also encompasses memory loss, speech impairment or aphasia, anosmia, limb weakness or even hemiparesis. [symptoma.com]

Patients may progress to a lethargy, confusion, and delirium. [symptoma.com]

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Whipple Disease

Introduction Whipple's disease (WD) is a rare condition caused by infection with Gram-positive bacilli ( Tropheryma whipplei ) characterised by fever, diarrhoea, arthropathy, apathy [jmedicalcasereports.com]

Some people with this disorder may experience a decrease in intellectual abilities, and an impairment of memory, judgment, and/or abstract thought. [rarediseases.org]

Occasionally, the loss of intellectual skills progresses to dementia. [rarediseases.org]

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Wernicke-Korsakoff Syndrome

The case of an alcoholic man is reported who survived a suicidal hanging attempt, and subsequently suffered of amnesia, dementia, apathy and behavioural abnormalities. [ncbi.nlm.nih.gov]

[…] dementia Problems with muscular coordination Personality changes, including impaired memory, judgment, and thinking Impaired vision Insomnia Depression Lethargy As CJD progresses [goinggentleintothatgoodnight.com]

The effect of alcohol abuse on the body can produce several additional psychological and physical signs, detected by doctors or family members and often including: Apathy [dementia.org]

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Mercury Poisoning

[…] gut dysbiosis caused by mercury (17) Alzheimer’s Disease Amylotrophic Lateral Sclerosis (ALS) Ankylosing spondylitis Aneurysm Anger Anorexia (9, 15) Anxiety (9, 17, 18) Apathy [liveto110.com]

Continued exposure leads to progressive tremor and erethism, a syndrome characterized by red palms, emotional lability, and memory impairment. [doi.org]

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