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20 Possible Causes for Aphthous Stomatitis, Bicytopenia

  • Vitamin B12 Deficiency

    Laboratory data revealed bicytopenia with macrocytic anemia and methylmalonic acid in the urine, consistent with vitamin B12 deficient anemia.[]

  • Adenovirus Infection

    […] encephalopathy, myocarditis, rash) was diagnosed with adenovirus-associated macrophage activation syndrome according to clinical and laboratory parameters (fever, hepatosplenomegaly, bicytopenia[]

  • Drug-induced Neutropenia

    Bicytopenia: adverse effect of risperidone. Current Psychiatry. 2014;13(4):E1. 5. Meylan C, Bondolfi G, Aubert AC, Baumann P.[] Review was limited to articles focusing on leukopenia, neutropenia, agranulocytosis, bicytopenia, and underlying pathophysiological mechanisms.[]

  • Agranulocytosis

    Since there was a possibility of autoimmune etiology for bicytopenia, rheumatology opinion was sought following which CANCA (cytoplasm antineutrophil cytoplasmic antibodies[]

  • Acute Leukemia

    A 43-year-old female presented with leukocytosis and bicytopenia.[] Initial CBC showed bicytopenia, elevated blood urea, creatinine, and serum uric acid, while abdominal ultrasonography revealed bilateral renal enlargement.[]

  • Acute Myelocytic Leukemia

    In contrast to patients with RA and only dyserythropoiesis, patients with multilineage dysplasia have bicytopenia or pancytopenia, a higher incidence of cytogenetic abnormalities[]

  • Bullous Pemphigoid

    For patients on azathioprine, two developed transaminitis and one had bicytopenia.[]

  • Lymphoproliferative Syndrome 1

    […] the male Pt. 1 presented with failure to thrive, mild fever, extensive splenomegaly (12 cm in length, as assessed with ultrasound imaging), generalized lymphadenopathy, bicytopenia[] stomatitis ; Recurrent infections ; Splenomegaly ; Stomatitis ; Thrombocytopenia Associated Genes ITK (Withdrawn symbols: EMT, LYK, PSCTK2 ) Mouse Orthologs Itk (Withdrawn[] stomatitis Immune dysregulation Stomatitis Generalized lymphadenopathy Abdominal pain Sporadic Nausea and vomiting Autoimmune hemolytic anemia Gastrointestinal hemorrhage[]

  • Familial Neutropenia

    RCUD and MDS-U categories in 196 patients with less than 5% marrow blasts, Maassen et al. found 28% RA, 6% RT, 13% RN, 20% patients with no cytopenia, and 34% patients with bicytopenia[] Most patients suffer from frequent aphthous stomatitis and gingival hyperplasia, leading to early loss of permanent teeth.[]

  • Pediatric Systemic Lupus Erythematosus

    Bicytopenia (12.2%) was detected in 6 patients, with anemia and leucopenia as the most common combination in 4 out of the 6 patients.[] Mucocutaneous lesions may include vasculitis and ulceration of the hard palate, aphthous stomatitis, and less frequently ulcers or perforation of the nasal mucosa or septum[]

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