Aphthous Ulceration: Causes & Reasons

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Possible Causes for Aphthous Ulceration

Aphthous Stomatitis

Background Aphthous stomatitis, also known as recurrent aphthous ulcers or canker sores, is among the most common oral mucosal lesion physicians and dentists observe. [emedicine.com]

Aphthous stomatitis (AS) is also referred to as recurrent aphthous ulcers (RAU) or canker sores. [symptoma.com]

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers). Cochrane Database Syst Rev. 2012 Sep 12. 9:CD005411. [Medline]. [emedicine.com]

Stomatitis

aphthous stomatitis. [55] Still, the frequency of serum immunoglobulin G antibodies to H pylori is not increased in recurrent aphthous ulcers, and the organisms have never [emedicine.medscape.com]

[…] patients with recurrent aphthous stomatitis 62 days ago Read Recurrent aphthous ulcers-a Toll-like receptor-mediated disease? [terkko.helsinki.fi]

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers). Cochrane Database Syst Rev. 2012 Sep 12. 9:CD005411. [Medline]. [emedicine.medscape.com]

Gingivostomatitis

Abstract It is thus apparent from the results of various studies that the conditions called aphthous ulcer (canker sore), herpes labialis, aphthous stomatitis, herpetic stomatitis [ajodo.org]

stomatitis on the labial mucosa.jpg 3 000 × 2 863; 1,15 MB Aphthous stomatitis.jpg 1 280 × 1 280; 130 KB Aphthous ulcer in the back of the mouth.jpg 640 × 606; 98 KB Aphthous [commons.wikimedia.org]

Herpes simplex and aphthous ulcerations: presentation, diagnosis and management--an update. Gen Dent. 2003 Nov-Dec;51(6):510-6. [PubMed: 15055647] 14. [ncbi.nlm.nih.gov]

Herpes Labialis

This activity has undergone a content review and was updated to reflect the latest research and clinical developments regarding herpes labialis and aphthous ulcers. [pharmacytimes.com]

aphthous stomatitis.[5] It is termed major aphthous ulceration (MaAU) or major recurrent aphthous stomatitis (MaRAS). [en.wikipedia.org]

Oral herpes infections should not be confused with canker sores (aphthous ulcers). [dentalresource.org]

Herpes Simplex Gingivostomatitis

Herpes simplex and aphthous ulcerations: presentation, diagnosis and management--an update. Gen Dent. 2003 Nov-Dec; 51 (6):510-6. [ PubMed : 15055647 ] 11. [ncbi.nlm.nih.gov]

The differential diagnosis of recurrent aphthous ulcers is extensive. [journals.lww.com]

Lesions/ulcers for herpetic gingivostomatitis may also be found on the palate and keratinzied gingivae hence aphthous ulcers can be ruled out. [en.wikipedia.org]

Recurrent Oral Ulceration

Aphthous ulcers Also known as apthae, recurrent aphthous stomatitis (RAS), recurrent oral aphthae, Mikulicz ulcers, Sutton’s ulcer, periadenitis mucosa necrotica recurrens [dermcoll.edu.au]

They are also called aphthae, aphthosis, aphthous stomatitis and canker sores. [dermnetnz.org]

The most common presentation of mouth ulcers is with painful, recurrent aphthous stomatitis, also known as aphthosis, aphthae, aphthous ulceration and canker sores. [dermnetnz.org]

Radiation Stomatitis

Most ulcers are due to local causes such as trauma or burns, but recurrent aphthous stomatitis and cancer must always be considered. [nature.com]

ulcers. [mdedge.com]

Aphthous stomatitis, also known as recurrent aphthous ulcers (RAU) or canker sores, is a specific type of stomatitis that presents with shallow, painful ulcers that are usually [medical-dictionary.thefreedictionary.com]

Behçet Disease

Behçet's disease (BD) is a recurrent inflammatory disease involving chronic recurrent oral aphthous ulcers (aphthae), uveitis, skin lesions and genital ulcers. [ncbi.nlm.nih.gov]

Complex aphthosis is characterized by recurrent oral and/or genital aphthous ulcers. [ncbi.nlm.nih.gov]

Behçet disease is a multisystemic chronic inflammatory disorder characterized by recurrent oral aphthous ulcers, genital ulcers, uveitis, and skin lesions. [ncbi.nlm.nih.gov]

Mevalonate Kinase Deficiency

The febrile period is accompanied by lymphadenopathy, arthralgia, abdominal pain, diarrhea, aphthous ulcers, and varying degree of skin involvement. [ncbi.nlm.nih.gov]

At age 4 years he progressed to more typical attacks of periodic attacks of fever, abdominal pain, oral aphthous ulcers, cutaneous rash and leukocytosis. [ncbi.nlm.nih.gov]

ulcers. [ncbi.nlm.nih.gov]

Primary Herpes Simplex Infection

Oral herpes infections should not be confused with canker sores (aphthous ulcers). [dentalresource.org]

(primarily affecting the oral mucosa and lip borders ) Differential diagnoses Shingles ( Herpes zoster ) Aphthous ulcers Herpangina Hand, foot, and mouth disease Candidiasis [amboss.com]

The differential diagnosis of nongenital herpes simplex virus infection includes aphthous ulcers, acute paronychia, varicellazoster virus infection, herpangina, herpes gestationis [aafp.org]

Acatalasia

Altenburg A, El-Haj N, Micheli C, Puttkammer M, Abdel-Naser MB, Zouboulis CC: The treatment of chronic recurrent oral aphthous ulcers. [aerzteblatt.de]

Angular cheilitis, Aphthous ulcer, Behcet's disease, Black hairy tongue, Caviar tongue, Cheilitis exfoliativa, Cheilitis glandularis, Cheilitis granulomatosa, Cutaneous [loot.co.za]

Correspondence Dtsch Arztebl Int 2015; 112(13): 222 ; DOI: 10.3238/arztebl.2015.0222b Article References Metrics The list of important differential diagnoses of aphthous ulcers [aerzteblatt.de]

Muckle-Wells Syndrome

Associated findings may include renal amyloidosis (and renal insufficiency), aminoaciduria, conjunctivitis, abdominal pain, angioedema, meningitis, and aphthous ulceration [accessanesthesiology.mhmedical.com]

While periodic fever adenitis pharyngitis aphthous ulcer (PFAPA) syndrome (aphthous stomatitis, pharyngitis, and adenitis), systemic juvenile idiopathic arthritis (sJIA), [mayocliniclabs.com]

Oral and vaginal aphthous ulcers may be present. Cervical lymphadenopathy is a common manifestation of HIDS, as are severe headache and splenomegaly. [emedicine.medscape.com]

PFAPA Syndrome

Skip to main content Language Options Periodic fever adenitis pharyngitis aphthous ulcer (PFAPA) syndrome P Periodic fever adenitis pharyngitis aphthous ulcer (PFAPA) syndrome [aboutkidshealth.ca]

ulcers, pharyngitis, and cervical adenitis. [jamanetwork.com]

Periodic fever, aphthous stomatitis, pharyngitis, and adenopathy syndrome: clinical characteristics and outcome. [link.springer.com]

Gingivosis

Chlorhexidine 0.12 - 0.2% - rinse mouth for 1 minute BD with 5 ml diluted with 5 - 10 ml water (adult dose) primary cause for mucosal ulceration or inflammation (aphthous [gpnotebook.co.uk]

A purulent lesion in oral vestibule of an S-year-old patient is most likely a) Pyogenic granuloma b) Odontogenic fistula c) Infected aphthous ulcer d) Isolated herpes lesion [mdsclasses.com]

Read more » Canker Sores (Aphthous Stomatitis Or Recurrent Mouth Ulcers) This disease causes painful, round ulcers to develop on the linings of the cheeks and lips, the tongue [colgateprofessional.com]

Upper Gingival Carcinoma

If aphthous ulcers and/or herpetic ulcers occur with regularity (every month or two), there are some predisposing conditions to check out. [fauquierent.net]

Aphthous Ulcer : Benign. [capedental.com]

The most common are aphthous ulcers which are relatively flat but extremely painful ulcers. There may or may not be a red rim around the white center. [fauquierent.net]

Drug-induced Neutropenia

It lasts for approximately 10 days; during this time, gingival inflammation and aphthous ulcer occur. [medical-dictionary.thefreedictionary.com]

[…] of Recurrent Aphthous Ulcers of Major type. [jiaomr.in]

Keeping in mind the previous history of occasional small ulcers which the patient had been experiencing since the last five to seven years, we formulated a provisional diagnosis [jiaomr.in]

Cyclic Neutropenia

Symptoms include: Aphthous ulcers (ulcers in the mouth) Throat inflammation (pharyngitis) Gum inflammation (gingivitis) Skin infections Fever Who Is at Risk? [verywellhealth.com]

This is due to oscillation in the production of neutrophils by bone marrow. 1 The symptoms include fever, aphthous stomatitis, lymphadenopathy, malaise and sometimes severe [jpma.org.pk]

This is due to oscillation in the production of neutrophils by bone marrow.1 The symptoms include fever, aphthous stomatitis, lymphadenopathy, malaise and sometimes severe [jpma.org.pk]

Chemotherapy-induced Mucositis

Also, indicated for diffuse aphthous ulcers. [gelclair.com]

[…] erythematous halo, and they appear clinically identical to idiopathic aphthous stomatitis in otherwise healthy patients. [emedicine.medscape.com]

Oral ulceration: aphthous ulcers, erythema multiforme. Temporomandibular dysfunction. Phase II: Conditioning Neutropenic Phase Oropharyngeal mucositis. [cancer.gov]

Lower Gingival Carcinoma

Aphthous Ulcer : Benign. [capedental.com]

Cancer of the floor of mouth often looks like an ulcer and is painless. Sometimes people mistake this for a canker sore (aphthous ulcer). [cedars-sinai.edu]

Occasionally, a major aphthous ulcer will form and be so painful the patient cannot swallow food with extreme discomfort. [capedental.com]

Celiac Disease

Figure 4: Aphthous ulcers in the buccal mucosa. [jcda.ca]

Jejunal mucosal abnormalities in patients with recurrent aphthous ulceration. [doi.org]

Gluten sensitivity enteropathy in patients with recurrent aphthous stomatitis. BMC Gastroenterol. 2009;9:44. Cheng J, Malahias T, Brar P, Minaya MT, Green PH. [jcda.ca]

Primary HIV Infection

Oral thrush, hairy leukoplakia, and aphthous ulcers may be seen on oropharyngeal examination. [symptoma.com]

The primary role for biopsy is when aphthous ulcers are difficult to distinguish from herpes simplex virus (HSV) lesions. See Aphthous Stomatitis for more details. [reference.medscape.com]

Oral candidiasis, hairy leukoplakia, herpes lesions and aphthous ulcers can be diagnosed clinically. [symptoma.com]

Inflammatory Bowel Disease Type 1

Figure 1a Figure 1b Aphthous ulcers. [doi.org]

[…] in the lining of the gut these early ulcers are called "aphthous" ulcers. [gastro-info.co.nz]

Oral Crohn disease Oral involvement occurs in 8-9% of Crohn disease and may include: Gingival or mucosal swelling Cobblestoning of the buccal mucosa Aphthous ulcers Mucosal [dermnetnz.org]

Relapsing Polychondritis

Skin infection can cause aphthous ulcer and nodules on the entire skin. This chronic disease will often infect 2 or 3 organs at the same time. [diseasespictures.com]

Skin and mucous membranes: 20-30% of people with relapsing polychondritis have skin involvement, including aphthous ulcers, genital ulcers, and a number of non-specific skin [en.wikipedia.org]

ulcers, sterile pustules, livedo reticularis), especially in those cases associated with myelodysplasia.) [clinicaladvisor.com]

Pemphigus

Akintoye SO, Greenberg MS (2005) Recurrent aphthous stomatitis. Dent Clin North Am 49: 31-47, vii-viii. [autoimmunediseases.imedpub.com]

Differential diagnosis The differential diagnoses will include other blistering eruptions of the skin and mucous membranes: Aphthous ulcers (oral lesions). [patient.info]

Recurrent aphthous ulceration (RAU) commonly appears first in childhood or adolescence. [autoimmunediseases.imedpub.com]

Marshall Syndrome

Marshall's syndrome is characterized by the appearance of a periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis in children. [symptoma.com]

PFAPA Periodic Fever, Aphthous stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) is also known as Marshall Syndrome. [autoinflammatory.org]

Pharyngitis, aphthous ulcers, and lymphadenopa-they are reported to occur during attacks and can be prominent features. [saidsupport.org]

Carcinoma of the Oral Cavity

[…] common aphthous ulcer that fails to heal A lump or mass that can be felt on the lip or in the mouth or throat Unusual bleeding, pain, or numbness in the mouth Difficulty [dermnetnz.org]

Cancer of the floor of mouth often looks like an ulcer and is painless. Sometimes people mistake this for a canker sore (aphthous ulcer). [cedars-sinai.edu]

These include: A white patch ( leukoplakia ) and/or red patch (erythroplasia) on the gums, tongue, or lining of the mouth A small sore or indurated ulcer that looks like a [dermnetnz.org]

Carcinoma of the Floor of the Mouth

Cancer of the floor of mouth often looks like an ulcer and is painless. Sometimes people mistake this for a canker sore (aphthous ulcer). [cedars-sinai.edu]

Vague symptoms of soreness in the regional mucosa could be attributed to an aphthous ulcer. [emedicine.medscape.com]

A small ulceration or nodular lesion may remain asymptomatic for long periods, so the patient may not seek medical attention. [emedicine.medscape.com]

Lichen Planus

The first 100 links for keywords "recurrent aphthous ulcers" and "oral lichen planus" were visited and content was downloaded within 24 h. [ncbi.nlm.nih.gov]

Oral or vaginal LP may resemble leukoplakia, and the oral lesions must also be distinguished from candidiasis, carcinoma, aphthous ulcers, pemphigus, mucous membrane (cicatricial [merckmanuals.com]

Oral or vaginal lichen planus may resemble leukoplakia, and the oral lesions must also be distinguished from candidiasis, carcinoma, aphthous ulcers, pemphigus, mucous membrane [msdmanuals.com]

Chikungunya

Painful aphthous -like ulcers that predominantly involve the oral mucosa and groin are also common [8–12]. [dermnetnz.org]

Photosensitive hyperpigmentation and intertriginous aphthous-like ulcers may be present. Vesiculobullous dermatosis can be seen in infants and children. [infectiousdiseaseadvisor.com]

ulcers (Fig., Supplemental Digital Content 1, http://links.lww.com/INF/C112 ). [journals.lww.com]

Erythema Multiforme

In addition to skin lesions, the patient had painful oral aphthous ulcers and fever, which led her to seek medical care in an emergency department. [elsevier.es]

Recurrent aphthous ulcers may mimic recurrent oral EM- aphthous ulcers present as isolated lesions, as compared to diffuse lesions of EM. [biomedpharmajournal.org]

ulcers, and fever. [elsevier.es]