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33 Possible Causes for Aplastic Anemia, Hepatosplenomegaly, Leukocyte Alkaline Phosphatase Increased

  • Viral Hepatitis

    HPV-B19 DNA has been found in liver samples from 67% of patients with non-A and non-E FHF and aplastic anemia, in 50% of patients with cryptogenic FHF without aplastic anemia[doi.org] Hepatosplenomegaly and laboratory evidence of mild to moderate hepatic dysfunction are the predominant features, with increased aminotransferases and alkaline phosphatase[doi.org] At Mayo Clinic, we reported two cases of a less severe form of hepatitis-associated aplastic anemia 79.[doi.org]

  • Leukoerythroblastic Anemia

    ANEMIA LEUKOERYTHROBLASTIC Anemia, leukoerythroblastic Leukoerythroblastosis Myelophthisic anemia (disorder) myelophthisis edit English myelophthisic anemia aplastic anemia[wikidata.org] alkaline phosphatase (LAP) score is increased Treatment Reduced intensity allogeneic stem cell transplant if intermediate to high risk or palliation of extramedullary hematopoiesis[pathologyoutlines.com] Usually there is hepatosplenomegaly due to myeloid metaplasia in which, in addition to leukoblastic cells, erythroblasts are constantly prominent and giant cells[jamanetwork.com]

  • Primary Myelofibrosis

    Aplastic anemia This is a condition where there is loss or suppression of production of RBCs.[news-medical.net] alkaline phosphatase (LAP) score is increased Treatment Reduced intensity allogeneic stem cell transplant if intermediate to high risk or palliation of extramedullary hematopoiesis[pathologyoutlines.com] The main clinical manifestations of PMF are anemia, bleeding, hepatosplenomegaly, fatigue, and fever.[ncbi.nlm.nih.gov]

  • Chronic Lymphocytic Leukemia

    Risk of aplastic anemia in patients using antiepileptic drugs. Epilepsia 47(7),1232–1236 ( 2006 ). Google Scholar 115 Chateauvieux S, Eifes S, Morceau F et al.[dx.doi.org] III Lymphocytosis; lymphadenopathy; hepatosplenomegaly, anemia IV Lymphocytosis, lymphadenopathy; hepatosplenomegaly, thrombocytopenia anemia CHRONIC LYMPHOCYTIC LEUKEMIA[medical-dictionary.thefreedictionary.com] anemia, European Journal of Haematology, 76, 6, (502-509), (2006).[doi.org]

  • Acute Lymphoblastic Leukemia

    Aplastic anemia, viral infections such as infectious mononucleosis, and vitamin B 12 and folate deficiency should be considered in the differential diagnosis of severe pancytopenia[web.archive.org] Massive hepatosplenomegaly as a presentation of ALL has not been described previously in any patient population.[ncbi.nlm.nih.gov] anemia.[cancertherapyadvisor.com]

  • Myeloproliferative Disease

    Abstract Long-term exposure to benzene has been associated with several blood malignancies, including aplastic anemia, myeloproliferative neoplasms, and different leukemias[ncbi.nlm.nih.gov] A myeloproliferative disorder manifested by thrombocytosis, a high leukocyte alkaline phosphatase (LAP) score and an increased red blood cell mass was found in a 64-yr-old[ncbi.nlm.nih.gov] Marked myeloid proliferation, anemia, thrombocytopenia and hepatosplenomegaly were present; leukocyte alkaline phosphatase and fetal hemoglobin were moderately elevated.[ncbi.nlm.nih.gov]

  • Myelodysplasia

    Aplastic Anemia and Myelodysplasia Association of Canada The Aplastic Anemia & Myelodysplasia Association of Canada (AAMAC) is a volunteer-run organization supporting patients[mds-alliance.org] An 18-month-old boy presented with fever, hepatosplenomegaly, jaundice, pancytopenia, hyperferritinemia, hypertriglyceridemia and evidence of hemophagocytosis and trilineage[ncbi.nlm.nih.gov] […] neonates) and at the other end of the spectrum, neonates with TAM may be very sick with disseminated leukaemic infiltration (10–20 % of neonates) presenting with massive hepatosplenomegaly[doi.org]

  • Polycythemia Vera

    An anonymous 17-question survey was emailed to members of the Myeloproliferative Neoplasm (MPN) Research Foundation database and Aplastic Anemia and MDS International Foundation[ncbi.nlm.nih.gov] alkaline phosphatase (LAP) score greater than 100 with increased blood serum levels of vitamin B 12 Laboratory testing BLOOD TESTS.[medical-dictionary.thefreedictionary.com] CNL is a rare myeloproliferative disorder characterized by a persistent increase of mature peripheral neutrophils, myeloid hyperplasia in bone marrow, hepatosplenomegaly,[kjim.org]

  • Agranulocytosis

    Analgesic use 29 to 180 days before admission was compared between 113 cases of aplastic anemia and 1724 controls.[jamanetwork.com] Physical examination revealed severe intoxication, dehydration, icteric skin, mucosis and massive hepatosplenomegaly.[ncbi.nlm.nih.gov] A total of 325 cases of agranulocytosis and 185 cases of aplastic anemia were enrolled, along with 2,500 controls.[bu.edu]

  • Acute Myelocytic Leukemia

    Aplastic anemia May have history of medications that cause aplastic anemia, such as chloramphenicol and nonsteroidal anti-inflammatory drugs.[online.epocrates.com] Although reduced leukocyte alkaline phosphatase activity is seen in CML, this is not a specific finding. CML has the following three clinical phases: Chronic phase.[cancer.gov] In all three patients, radionuclide imaging with technetium-99m sulfur colloid showed hepatosplenomegaly, decreased liver uptake, and increased splenic activity.[ncbi.nlm.nih.gov]

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