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26 Possible Causes for Areflexia, Hypertonicity of the Lower Limbs, Sensation Normal

  • Autosomal Recessive Lower Motor Neuron Disease with Childhood Onset

    DSMA4 is characterized by childhood onset, generalized muscle weakness and atrophy with denervation and normal sensation. Bulbar symptoms and pyramidal signs are absent.[uniprot.org] limbs, hypertonic urinary bladder, and impaired vibration sense.[clinicalgate.com] Paralysis spread to become generalized, except for the cranial nerves, and by age 16 years, patients were tetraplegic with areflexia, contractures, and scoliosis, and required[pediatricneurologybriefs.com]

  • Lower Motor Neuron Syndrome with Late-Adult Onset

    sensation -normal nerve conduction velocities -denervation on EMG -dec. # of motor units -muscle biopsy shows atrophic fibers & fiber grouping -seen in MRI -present: lower[brainscape.com] limbs, hypertonic urinary bladder, and impaired vibration sense.[clinicalgate.com] […] and cognition – normalSensation and cognition – normal -Lower motor neuron diseaseLower motor neuron disease - Wasting- Wasting - Fasciculation- Fasciculation - - Flaccid[slideshare.net]

  • Autosomal Recessive Spastic Paraplegia Type 49

    Vibration sense was described as normal at the ankles. Pinprick sensation was decreased in both feet.[academic.oup.com] The lower limb spasticity is the prominent finding on examination, particularly in the hamstrings, quadriceps, and ankles.[jnnp.bmj.com] […] mesenchymal dysgenesis Harlequin syndrome Microcoria, congenital Pseudoxanthoma elasticum, forme fruste Laurin-Sandrow syndrome Spinocerebellar ataxia 34 Cerebellar ataxia, areflexia[checkrare.com]

  • Paraparesis

    Sensory examination showed loss of vibration in lower limbs with normal sensation to pinprick, fine touch and propioception.[n.neurology.org] The lower limb spasticity is the prominent finding on examination, particularly in the hamstrings, quadriceps, and ankles.[jnnp.bmj.com] Here, we report an atypical manifestation in a 21-month-old boy presenting with flaccid paraparesis and areflexia.[ncbi.nlm.nih.gov]

  • X-linked Parkinsonism-Spasticity Syndrome

    There was a mild impairment of vibration sense, but proprioception and superficial sensation were normal.[journals.plos.org] The lower limb spasticity is the prominent finding on examination, particularly in the hamstrings, quadriceps, and ankles.[jnnp.bmj.com] Clinical neuromuscular manifestations include areflexia, sensory-motor neuropathy, and variable weakness and atrophy.[ojrd.biomedcentral.com]

  • Autosomal Dominant Spastic Paraplegia Type 31

    Peripheral nerves are normal in patients with pure HSP. 38. Vibratory sensation is often mildly diminished in the distal lower extremities. 39.[slideshare.net] The lower limb spasticity is the prominent finding on examination, particularly in the hamstrings, quadriceps, and ankles.[jnnp.bmj.com] Areflexia follows with development of pes cavus and hammertoes.[disorders.eyes.arizona.edu]

  • Spastic Paraplegia

    There was a mild impairment of vibration sense, but proprioception and superficial sensation were normal.[journals.plos.org] The lower limb spasticity is the prominent finding on examination, particularly in the hamstrings, quadriceps, and ankles.[jnnp.bmj.com] Affected individuals also have abnormal or absent reflexes (areflexia).[ghr.nlm.nih.gov]

  • Cerebral Palsy

    […] earlier than 18 months of age) For the mother Any adverse effects severe enough to stop treatment Postpartum haemorrhage (however reported by the trialists) Mode of birth (normal[doi.org] All had spasticity affecting predominantly the lower limbs, although 2 also had mild hypertonia and ataxia of the upper limbs.[ncbi.nlm.nih.gov] An unusual variant of acute idiopathic polyneuritis (syndrome of ophthalmoplegia, ataxia and areflexia). N Engl J Med. 1956;255:57–65.[dx.doi.org]

  • Pure Hereditary Spastic Paraplegia

    Weakness: Some patients Distal Hands & Feet Fasciculations Sensation: Normal or Reduced (Panmodal; Posterior column) Bladder: Often normal Progression Over few years or Slow[neuromuscular.wustl.edu] […] bladder) and extensor plantar responses with weakness of a pyramidal distribution in the lower limbs.[ruralneuropractice.com] There was total areflexia of all four limbs and plantar reflexes were absent.[cags.org.ae]

  • Autosomal Recessive Spastic Paraplegia Type 20

    […] is normal • Moderate CPK • AUTOSOMAL RECESIVE SMN1 gene deletions on Chr. 5 (SMN1 is spliced without Exon 7) SMN2 is usually spliced out but when it is there it can help[quizlet.com] limb spasticity, pyramidal weakness, hyperreflexia and hypertonic bladder involvement.[medicbind.com] […] typical phenotype is progressive spinal and cerebellar ataxia (loss of sensory ganglion cells and degeneration of the posterior columns and spinocerebellar tracts), with areflexia[elsevier.es]

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