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57 Possible Causes for Arterial Blood pH Increased, Bicarbonate Decreased

  • Respiratory Alkalosis

    Measurement of the serum bicarbonate permits definitive diagnosis: acute respiratory alkalosis: serum bicarbonate decreases by 2 mM for every 10 mmHg (or 1.33kPa) decrease[] […] reduces the arterial levels of carbon dioxide that, in turn, elevates the blood pH beyond the normal range (7.35-7.45) Statements Identifiers Sitelinks Wikipedia (13 entries[] RESULTS: For each decrease of 1 mm Hg (0.13 kPa) in the PaCO2, the plasma bicarbonate concentration decreased by 0.41 mmol per liter in the subjects who started with a normal[]

  • Hyperventilation

    […] via a decrease in bicarbonate reabsorption.[] […] the pH of arterial blood (blood flowing through the arteries) and a decrease in the pressure of carbon dioxide in the arteries and alveoli.[] There is approximately a 2% decrease in CBF for every 1 mmHg decrease in PaCO2 levels.[]

  • Metabolic Alkalosis

    It is the result of an increase in bicarbonate production, a decrease in bicarbonate excretion, or a loss of hydrogen ions.[] Patients with ACET treatment significantly decreased their serum bicarbonate (p 0.01 versus baseline) and arterial blood pH (p 0.0001), increased their PaO(2)/FiO(2) ratio[] The hypothesis of this study was that elevated plasma bicarbonate levels decrease respiratory drive and minute ventilation.[]

  • Alkalosis

    The decreased bicarbonate concentration realigns the Henderson-Hasselbalch Equation for the bicarbonate buffer and thus largely corrects the ECF pH.[] Increases in arterial blood pH depress respiratory centers. The resulting alveolar hypoventilation tends to elevate PaCO2 and restore arterial pH toward normal.[] The increased H concentration in blood leads to decrease in pH and acidosis. Normal partial pressure of CO2 in arterial blood is about 40 mm Hg.[]

  • Gram-Negative Septicaemia

    Serum bicarbonate is usually low, and serum and blood lactate levels increase. As shock progresses, metabolic acidosis worsens, and blood pH decreases.[] Hyperventilation with respiratory alkalosis (low Pa co 2 and increased arterial pH) occurs early, in part as compensation for lactic acidemia.[] Serum bicarbonate is usually low, and serum and blood lactate levels increase. As shock progresses, metabolic acidosis worsens, and blood pH decreases.[]

  • Low Chloride

    - Tachycardia - Pitting edema - Dysthythmias - Coma Hyperchloremia Lab Results: - Increased Na chloride - Increased serum Na - Decreased serum pH - Decreased Na bicarbonate[] Hypochloremia Physiological alterations ECF volume contraction Intracellular acidosis Potassium depletion Increased bicarbonate production Decreased serum osmolarity Hypochloremia[] Factors which can cause decreased levels : Drugs : aldosterone, bicarbonates, corticosteroids, cortisone, hydrocortisone, loop diuretics, thiazide diuretics, and triamterene[]

  • Milk-Alkali Syndrome

    In addition, alkalosis following vomiting with volume depletion and excessive concentrations of bicarbonate, further decreases the capacity of the kidneys to excrete serum[] PTH deceases reabsorption of bicarbonate; hence low levels of the hormone promote bicarbonate accumulation, which further leads to a decrease in the PTH levels.[] Activation of calcium-sensing receptors increases calcium reabsorption, absorption of bicarbonate, and natriuresis (maintaining alkalotic state).[]

  • Hypokalemia

    Gastrointestinal complications Hypokalemia decreases gut motility, which can lead to or exacerbate an ileus.[] The diuretic acetazolamide, which causes metabolic acidosis by decreasing bicarbonate reabsorption in the proximal tubule, increases potassium excretion by increasing the[] ) Potassium excretion is decreased by the following factors: Absolute aldosterone deficiency or resistance to aldosterone effects Low sodium delivery to the collecting duct[]

  • Cystic Fibrosis

    Pancreatic disease As a part of normal digestion, stomach acid is neutralized by pancreatic bicarbonate, leading to the optimal pH for pancreatic enzyme action.[] […] which there is abnormal gut motility (eg, Hirschsprung disease, chronic intestinal pseudo-obstruction) have been associated with meconium ileus–like disease, suggesting that decreased[]

  • Salicylate Poisoning

    However , acetazolamide has a tendency to decrease systemic Ph because of bicarbonate loss in urine and can potentially increase the neurotoxicity of salicylate.[] […] via sodium bicarbonate.[] Overall, the suggested approach to fluids in the ACMT document is to dissolve 3 ampules of sodium bicarbonate and 30-40 mEq of potassium chloride into 1 liter of 5% dextrose[]

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