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4,125 Possible Causes for Arthralgia, Corneal Opacity, Early-Onset Coronary Artery Stenosis

  • Mucopolysaccharidosis 1 H-S

    onset severe regurgitation and stenosis coronary artery disease cardiomegaly: initially hypertrophic then dilated Other features include prominent perivascular spaces hepatosplenomegaly[radiopaedia.org] Less commonly reported infusion reactions included nausea, diarrhea, feeling hot or cold, vomiting, pruritus, arthralgia and urticaria.[aldurazyme.com] Corneal opacity is seen between two and four years of age and requires keratoplasty to restore sight.[orpha.net]

  • Pseudo-Hurler Polydystrophy

    onset severe regurgitation and stenosis coronary artery disease cardiomegaly: initially hypertrophic then dilated Other features include prominent perivascular spaces hepatosplenomegaly[radiopaedia.org] opacity 0007957 Hyperlordosis Prominent swayback 0003307 Inguinal hernia 0000023 5%-29% of people have these symptoms Abnormal aortic valve morphology 0001646 Cleft palate[rarediseases.info.nih.gov] Ophthalmologic findings include corneal opacities on slit-lamp examination noted as diffuse stromal granularities.[emedicine.medscape.com]

  • Mucopolysaccharidosis 1H

    onset severe regurgitation and stenosis coronary artery disease cardiomegaly: initially hypertrophic then dilated Other features include prominent perivascular spaces hepatosplenomegaly[radiopaedia.org] Hurler syndrome patients have progressive mental degeneration, a broad forehead with heavy eyebrows, enlarged and deformed skull, small stature, corneal opacities, hepatosplenomegaly[medicinenet.com] There is dwarfism, many skeletal deformities, corneal opacity, heart abnormalities, mental retardation and early death. The condition was once known as ‘gargoylism’.[medical-dictionary.thefreedictionary.com]

  • Winchester Syndrome

    Arthralgia and loss of function of joints in the hands is a documented complaint. Initially, findings may be almost identical to those of rheumatic arthritis.[symptoma.com] The syndrome is characterized by short stature, coarse face, corneal opacities, generalized osteolysis and progressive painful arthropathy with joint stiffness and contractures[ncbi.nlm.nih.gov] Abstract The Winchester syndrome, a rare inherited disorder, is characterized by dwarfism, carpal-tarsal osteolysis, rheumatoid-like small joint destruction, corneal opacities[ncbi.nlm.nih.gov]

    Missing: Early-Onset Coronary Artery Stenosis
  • Mucopolysaccharidosis

    The most frequently reported adverse reactions included: chills, vomiting, nausea, arthralgia, diarrhea, tachycardia, abdominal pain, blood pressure increased, and oxygen[biomarin.com] Regardless of phenotype, all patients had various degrees of infiltrated facies, short stature, dysostosis multiplex, joint contractures, and corneal opacity typical of the[ncbi.nlm.nih.gov] The symptoms usually include hearing impairment, carpal tunnel syndrome, joint stiffness, discrete corneal opacities, and papilledema.[icd9data.com]

    Missing: Early-Onset Coronary Artery Stenosis
  • Gaucher Disease

    […] and EU Summary of Product Characteristics (SmPC) were evaluated with regard to frequency, drug-relatedness, severity, seriousness, duration, and timing of onset: headache, arthralgia[ncbi.nlm.nih.gov] Ophthalmic evaluation in a 57-year-old white patient demonstrated corneal opacities scattered throughout the cornea.[ncbi.nlm.nih.gov] […] infusion reactions such as urticaria, arthralgia, headache, and chest pain due to IV administration.[symptoma.com]

    Missing: Early-Onset Coronary Artery Stenosis
  • Mucopolysaccharidosis 1

    The most frequently reported adverse reactions included: chills, vomiting, nausea, arthralgia, diarrhea, tachycardia, abdominal pain, blood pressure increased, and oxygen[biomarin.com] Typical symptoms are stiff joints, corneal opacities, carpal tunnel syndrome and mild skeletal changes. Aortic valve disease can be present.[orpha.net] Less commonly reported infusion reactions included nausea, diarrhea, feeling hot or cold, vomiting, pruritus, arthralgia and urticaria.[aldurazyme.com]

    Missing: Early-Onset Coronary Artery Stenosis
  • Mucopolysaccharidosis 6

    A large head, short neck, corneal opacity, open mouth associated with an enlarged tongue, enlargement of skull, and a long antero-posterior dimension are the main characteristic[unboundmedicine.com] [rarediseases.org] Eyes Corneal Opacity A large head, short neck, corneal opacity , open mouth associated with an enlarged tongue, enlargement of skull, and a long antero-posterior[symptoma.com] Corneal opacities can be detected with slitlamp examination. Restricted joint movement, including claw-hand deformities, appears in the first few years of life.[emedicine.medscape.com]

    Missing: Early-Onset Coronary Artery Stenosis
  • Congenital Syphilis

    Although rare, bow legs, recurrent fever, anemia, and inflammatory arthralgias may be manifestations of late CS.[ncbi.nlm.nih.gov] Eyes revealed dense corneal opacities with complete loss of vision in right eye. Left eye was normal. Patient was edentulous.[ijdvl.com] DGI often results in petechial or pustular acral skin lesions, asymmetrical arthralgia, tenosynovitis, or septic arthritis.[cdc.gov]

    Missing: Early-Onset Coronary Artery Stenosis
  • Cockayne Syndrome

    Cataracts and cloudiness of the cornea (corneal opacity) are common. The loss of and damage to nerves of the optic nerve, causing optic atrophy can occur.[en.wikipedia.org] Both eyes had low visual acuity, corneal epithelial degeneration, punctate opacities of the lens, and retina disorders.[ncbi.nlm.nih.gov] Severe keratitis, which may cause opacity of the cornea and corneal vascularization Increased pigmentation of the eyelids with loss of lashes Atrophy of the skin of the lids[ojrd.biomedcentral.com]

    Missing: Early-Onset Coronary Artery Stenosis

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