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11 Possible Causes for Arthralgia, Exanthema, Systemic Autoinflammation

  • Erythema Nodosum

    Ahmet Gül, Behçet Disease, Textbook of Autoinflammation, 10.1007/978-3-319-98605-0_35, (647-665), (2019).[doi.org] In this case report, we suggest arthralgia, EN, and Achilles tendinitis could coexist with AGPB.[ncbi.nlm.nih.gov] […] skin syndrome, Impetigo, Boil, Carbuncle ) · Strep ( Impetigo ) · Corynebacterium ( Erythrasma ) Viral skin disease Wart · Molluscum contagiosum · Erythema infectiosum · Exanthema[wikidoc.org]

  • Cryopyrin-Associated Periodic Syndrome

    Hoffman, Autoinflammation: translating mechanism to therapy, Journal of Leukocyte Biology, 90, 1, (37-47), (2011). Keith A. Sikora and Alexei A.[doi.org] […] syndrome caused by mutations of the CIAS1 gene (currently named NLRP3), and is characterized by periodic attacks of an urticaria-like rash, fever, head-ache, conjunctivitis and arthralgia[ncbi.nlm.nih.gov] Past history: at the age of 20, he complained of arthralgia/arthritis and bilateral hypoacusis.[ncbi.nlm.nih.gov]

  • Familial Mediterranean Fever

    Intrinsic apoptosis seemed irrelevant for confining synovial autoinflammation, but regulation through pyroptosis or the adaptive immune system remains possible. arthritis[pediatrics.aappublications.org] He had frequent and severe arthralgias, despite colchicine, then etanercept and adalimumab, impairing his quality of life.[ncbi.nlm.nih.gov] Clinical differential diagnoses encompass erysipelas, erysipelas-like rashes after joint replacements, mercury exanthemas and malignant counter-parts (e.g. erysipelas melanomatosa[oatext.com]

  • Vasculitis

    To date, several cases of systemic lupus erythematosus, Aicardi-Goutieres syndrome, familial chilblain lupus, retinal vasculopathy-cerebral leukodystrophy have been reported[ncbi.nlm.nih.gov] Abstract IgA vasculitis (IgAV) commonly occurs in young children, who present with a tetrad of purpura, abdominal pain, arthralgia and nephritis.[ncbi.nlm.nih.gov] […] disease include fever lasting over 5 days, bilateral congestion of the conjunctiva, erythema of the lips, buccal mucosa and the tongue, cervical lymphadenopathy, polymorphous exanthema[symptoma.com]

  • Sweet Syndrome

    French, Autoinflammation behind the curtain, British Journal of Dermatology, 178, 3, (581-582), (2018). Pedro Secchin, Maria K. Gomes, Danielle C.[doi.org] Her course of disease was complicated by arthralgias, episcleritis, headaches, and erythema nodosum-like subcutaneous involvement.[ncbi.nlm.nih.gov] It presents clinically with polymorphic skin lesions, fever, arthralgia, and peripheral leukocytosis. In general, it is associated with infections, malignancy and drugs.[ncbi.nlm.nih.gov]

  • CINCA Syndrome

    […] autoinflammatory conditions characterized by chronic systemic inflammation due to an abnormal regulation of the innate immune system.[ncbi.nlm.nih.gov] In terms of joint involvement, recurrent flares that may be accompanied with overgrowth of the patella are most frequently reported, together with arthralgia that can be severe[symptoma.com] She reported experiencing daily episodes of urticaria-like rashes, fevers, and arthralgia since birth.[joii-journal.springeropen.com]

  • Pericarditis

    More recently, there has been evidence that the innate immune system and autoinflammation contribute to acute and recurrent pericarditis. [6, 7] Chronic idiopathic pericarditis[emedicine.com] An early set of symptoms - a prodrome - of fever (usually 39 C), malaise and myalgia and/or arthralgia is common.[escardio.org] […] complex with a key role in innate immunity) lead to overproduction of pro-inflammatory cytokines such as IL-1β, triggering different inflammatory symptoms, such as fever, exanthema[analesdepediatria.org]

  • Ichthyosis and Male Hypogonadism

    […] autosomal dominant systemic disorder characterized by recurrent blistering skin lesions with a dense inflammatory infiltrate and variable involvement of other tissues, including[mendelian.co] […] acute appendicitis 【急性中毒性表皮剥離(剥脱)】*epidermolysis acuta toxica[L] (略 EAT) 【急性洞炎】*acute sinusitis 【急性脳症】*acute encephalopathy 【急性副鼻腔炎】*acute paranasal sinusitis 【急性発疹】*acute exanthema[medo.jp] […] gestational age Recurrent pneumonia Elevated serum creatine phosphokinase Obesity Metaphyseal widening Respiratory distress Myopia Proteinuria Premature birth Brachydactyly Arthralgia[mendelian.co]

  • Anonychia Congenita Totalis

    […] with infantile enterocolitis (AIFEC) Immunoglobulin G4-related disease Eosinophilic sinusitis Nervous system diseases Neurodegenerative diseases Alzheimer’s disease Lewy[csirnotes.com] Thickened skin Type I diabetes mellitus Absent eyebrow Autoimmune hemolytic anemia Myositis Thrombocytosis Severe combined immunodeficiency Lymphopenia Pain Fever Arthritis Arthralgia[mendelian.co] […] subitum [sixth disease] B08.20 Exanthema subitum [sixth disease], unspecified B08.21 Exanthema subitum [sixth disease] due to human herpesvirus 6 B08.22 Exanthema subitum[eicd10.com]

  • Neonatal Inflammatory Skin and Bowel Disease 2

    Autoinflammation, LipoDystrophy, and Dermatosis syndrome (ALDD) ALDD is a systemic inflammatory condition starting within the first months of life, and comprising elevated[ojrd.biomedcentral.com] Ankle arthralgias are common.[autoinflammatory-search.org] Roseola infantum or exanthema subitum – Human herpesvirus 6 or 7 infection – High fever for 3-4 days – Followed by seizures – Generalized rash (trunk to extremities, face[learn.pediatrics.ubc.ca]

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