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18 Possible Causes for Arthralgia, Exertional Dyspnea, Testosterone Decreased or Increased

  • Sickle Cell Disease

    He presented with progressive severe dyspnea on exertion and lower extremity edema.[] The low testosterone levels may manifest as decreased muscle mass and bone mineral density, increased fat mass, central obesity, insulin resistance, decreased libido and energy[] […] factors like repeated testicular infarction which may be total or segmental has a probable underlying mechanism of testicular failure, impaired fertility, and reduced serum testosterone[]

  • Obesity

    Because dyspnea with exertion and lower extremity edema are often nonspecific signs of heart disease in obesity, 27–29 it may be difficult to clinically assess an obese individual[] Google Scholar 50 : Oral testosterone supplementation increases muscle and decreases fat mass in healthy elderly males with low-normal gonadal status.[] Side effects included diarrhoea (10%), and one patient each with arthralgia, abdominal pain, and vomiting.[]

  • Hypercholesterolemia

    Patients may have articular symptoms such as tendonitis or arthralgias. Patients have a history of unusual skin lesions.[] […] on exertion, diaphoresis, and abdominal distension. 9 Cardiologist Dr.[] At this time, we suggested that the patient decrease his dose of DHEA, increase his dose of pregnenolone, and visit his doctor to obtain a prescription for micronized testosterone[]

  • Anorexia Nervosa

    A 46-y-old woman with AN who had followed a carbohydrate- and a fat-deficient diet for 10 y was hospitalized for dyspnea on exertion.[] […] the risk of fractures Loss of muscle In females, absence of a period In males, decreased testosterone Gastrointestinal problems, such as constipation, bloating or nausea[] testosterone in males Musculoskeletal Complications [4] [3] [5] Rapid bone loss Increased risk for stress fractures Proximal muscle weakness Osteoporosis Linear growth retardation[]

  • Acromegaly

    Symptoms may include difficulty breathing upon exertion (dyspnea) and/or irregular heartbeats (arrhythmias).[] After therapy, homeostasis model assessment of insulin resistance, fasting insulin level, and insulin AUC decreased despite an increase in IHL and abdominal and thigh adipose[] […] adenoma, profuse sweating, acral growth, coarsening of facial features, and when suspected in conjunction with commonly associated conditions, such as carpal tunnel syndrome, arthralgia[]

  • Acidosis

    Abstract Background A 51-year-old man with HIV infection on highly active antiretroviral therapy presented with abdominal pain and exertional dyspnea.[] […] globulin, resulting in an overall decrease in circulating free testosterone.[] Arthralgias (mostly of large joints or the lower back) occur in about 15% of patients. Increased risk of depression and suicide is much publicized but probably rare.[]

  • Diabetes Mellitus

    There have been postmarketing reports of severe and disabling arthralgia in patients taking DPP-4 inhibitors.[] Many patients with diabetes do not have typical exertional chest pain.[] […] deficiency is also associated with type 2 diabetes.[48][49] Eating disorders may also interact with type 2 diabetes, with bulimia nervosa increasing the risk and anorexia[]

  • Thyrotoxicosis Factitia

    […] to induce long term remission - Monitor patients every 6-12 months after remission, if relapse occurs do RAI therapy - Adverse rxns include pruritic macropapular rashes, arthralgia[] dyspnea increased appetite increased frequency of bowel movements proximal muscle weakness irregular menses Signs of Graves' Disease tremors tachycardia flow murmurs warm[] : Differentiated thyroid carcinoma (papillary, follicular), Graves disease, nontoxic euthyroid or hyperthyroid goiter, Subacute thyroiditis DECREASED: Hypothyroidism, testosterone[]

  • Apathetic Thyrotoxicosis with Thyrotoxic Crisis

    Other rare reactions include neuritis, myalgia, arthralgia, hepatitis, thrombocytopenia, loss of taste, lymphadenopathy, edema, salivary gland enlargement and toxic psychosis[] Albumin Decreased binding Any cause of hypoalbuminaemia Increased binding Genetic variation Tranthyretin Increased binding Genetic variation Competition for binding sites[] "Minor adverse reactions include skin rash, urticaria, nausea, vomiting, epigastric distress, arthralgia, paresthesias, loss of taste, taste perversion, abnormal loss of hair[]

  • HIV Wasting Syndrome

    Common adverse events with rhGH therapy include blood glucose elevations, arthralgia, myalgia, and peripheral edema, but these usually respond to dose reduction or drug discontinuation[] Pneumocystis jiroveci pneumonia: (a) a history of dyspnea on exertion or nonproductive cough of recent onset (within the past 3 months); and (b) chest radiograph evidence[] However, testosterone in pharmacologic doses decreases high-density lipoprotein (HDL) cholesterol levels, and thus might increase risk of cardiovascular disease.[]

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