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108 Possible Causes for Arthralgia, Failure to Thrive, Risk of Cancer Possibly Increased

  • Farber Disease

    Severe cognitive disability, failure to gain motor skills, failure to thrive, and joint contractures developed.[ncbi.nlm.nih.gov] If you or your doctor thinks that you are at increased risk of developing cancer or may have an inherited risk of cancer, we can provide an estimate of your risk as accurately[dana-farber.org] METHODS: Here we describe a 2-year-old female, a product of a non-consanguineous Emirati union, who was quite well until 8 months of age when presented with failure to thrive[ncbi.nlm.nih.gov]

  • Hypothyroidism

    There is an association between chronic thyroiditis and thyroid nodules, but whether this association is related to an increased risk of thyroid cancer is controversial. 7[web.archive.org] Musculoskeletal system: muscle stiffness, weakness, cramps, mialgias, arthralgias, joint stiffness and effusions, Carpal Tunnel syndrome and delayed linear bone growth in[flexikon.doccheck.com] Infants and children may present more often with lethargy and failure to thrive. Women who have hypothyroidism may present with menstrual irregularities and infertility.[web.archive.org]

  • Hyper IgD Syndrome

    Risk factors Factors that increase the risk of developing thyroid cancer include: Being female Being older Having a history of radiation treatments to the head and neck Complications[mayoclinic.org] Hyper-IgD syndrome is a periodic fever syndrome that presents with recurrent episodes of high fever accompanied by lymphadenopathy, abdominal distress, arthralgias or arthritis[ncbi.nlm.nih.gov] […] to thrive,systemic organ involvement and neurocognitive delays.[autoinflammatory.org]

  • Hypervitaminosis A

    The Physicians' Health Study did not find an increased lung cancer risk in participants taking beta-carotene supplements, possibly because only 11% of physicians in the study[ods.od.nih.gov] Chronic HA affects multiple systems, with features such as arthralgia, bone pain, hair loss, desquamation of skin, eczematous lesions, photosensitivity, and petechiae.[symptoma.com] The patient is a 4-year-old girl with pancreatic-insufficient CF, gastroesophageal reflux, oral aversion, and failure to thrive requiring gastrostomy tube placement.[ncbi.nlm.nih.gov]

  • Arthritis

    risk of infection and possibly cancer Hypogammaglobulinemia Neutropenia Reactivation of hepatitis B IL-6 inhibitors ‡ Sarilumab 200 mg sc once q 2 wk Dosage can be reduced[merckmanuals.com] The characteristics present are chronic synovitis, arthralgia, impaired joint mobility in at least one joint, and erosion with destruction of cartilage and subchondral bone[ncbi.nlm.nih.gov] In young children, gastrointestinal presentations are common and include chronic diarrhea, failure to thrive, and abdominal distention; however, extraintestinal manifestations[ncbi.nlm.nih.gov]

  • Gaucher Disease

    As enzyme replacement and substrate reduction therapies are expensive and still associated with inflammation, increased risk of cancer and Parkinson disease, targeting C5aR1[ncbi.nlm.nih.gov] […] and EU Summary of Product Characteristics (SmPC) were evaluated with regard to frequency, drug-relatedness, severity, seriousness, duration, and timing of onset: headache, arthralgia[ncbi.nlm.nih.gov] The various symptoms and the age when they are most likely to present are as follows: [4] Newborn Congenital ichthyosis Organomegaly Failure to thrive Brain stem dysfunction[emedicine.medscape.com]

  • Hypopituitarism

    Earlier population and case control studies reported that upper quartile of circulating IGF-I is associated with a higher risk of developing cancer suggesting possible involvement[ncbi.nlm.nih.gov] Within days, he developed severe fatigue, myalgias and arthralgias.[ncbi.nlm.nih.gov] , fatigue Children/infants – failure to thrive Posterior pituitary (hypothalamic) Central diabetes insipidus Adults – polydipsia, polyuria, nocturia Children – vomiting, diarrhea[arupconsult.com]

  • Sjögren Syndrome

    A possible complication of Sjögren’s syndrome is an increased risk of developing lymphoma, a cancer of the lymphatic system, which is related to the immune system.[healthline.com] The most difficult challenge in diagnosis and therapy is patients with symptoms of fibromyalgia (arthralgia, myalgia, fatigue) and oral and ocular dryness in the presence[ncbi.nlm.nih.gov] Failure to thrive is an early symptom of the Imerslund Gräsbeck syndrome. Am J Pediatr Hematol Oncol 1994;16:177-80. 7. Stones DK, Ferreira M.[indianjnephrol.org]

  • Rheumatoid Arthritis

    risk of infection and possibly cancer Hypogammaglobulinemia Neutropenia Reactivation of hepatitis B IL-6 inhibitors ‡ Sarilumab 200 mg sc once q 2 wk Dosage can be reduced[merckmanuals.com] It can cause arthralgias and weakness in intrinsic muscles of the hand.[ncbi.nlm.nih.gov] Many ROHHAD patients have had clinical testing that has ruled out a PWS diagnosis, and key features of PWS, especially neonatal hypotonia and failure to thrive, are not observed[ojrd.biomedcentral.com]

  • Paraneoplastic Syndrome

    In the NSCLC and SCLC cohorts, the increased risk of potential PNS was greater in the first year following cancer diagnosis than in the subsequent years.[journals.plos.org] Sweet’s Syndrome  Acute febrile neutrophilic dermatosis  Associated with leukemia  Acute tender red nodules or plaques  Fever, arthralgia, oral lesions, eye involvement[slideshare.net] Infants and children with a small PDA are generally asymptomatic; infants with a large PDA present with signs of heart failure (eg, failure to thrive, poor feeding, tachypnea[merckmanuals.com]

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