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95 Possible Causes for Arthralgia, Hypoglycemia, Variable Hypoglycemia

  • Adrenal Insufficiency

    Type 2 PGAD is transmitted as an autosomal disorder with variable penetrance.[] Hypoglycemia occurred in three patients (10%) during the fasting day but not during the nonfasting day (P 0.23). Hypoglycemia was asymptomatic in two cases.[] […] vomiting and diarrhoea CVS: dehydration, hypotension, refractory shock, poor response to inotropes/pressors fever confusion CHRONIC ADRENAL INSUFFICIENCY GENERAL: weight loss, arthralgia[]

  • Diabetes Mellitus Type 1

    There was no significant between-group difference in the number of severe hypoglycemia events. (p 0.1276).[] The main concern is hypoglycemia, which can cause sudden incapacitation.[] […] overall hypoglycemia rate in type 2 DM.[]

  • Addison's Disease

    Abstract A 19-yr-old intact female variable flying fox ( Pteropus hypomelanus ) presented with lethargy, behavior changes, and substantial weight loss.[] ACTH stimulation tests and Insulin-induced hypoglycemia tests, imaging studies with CT scan and MRI may follow.[] […] has an insidious onset and presents with many non-specific symptoms and signs: - Weakness and fatigability (99%), anorexia (99%), nausea/vomiting, abdominal pain, myalgias/arthralgias[]

  • Growth Hormone Deficiency

    Hypoglycemia was present in 56 per cent of those with isolated HGH deficiency and in all with HGH and ACTH deficiencies.[] Glucagon injection during hypoglycemia resulted in a further decrease of blood glucose.[] A total of 55.2% of patients were reported to have experienced adverse events (AEs), including arthralgia, myalgia, abdominal distension and hypoaesthesia, and 4.5% had adverse[]

  • Myxedema

    Serum potassium levels are extremely variable. Blood glucose levels are generally in the normal range, but severe hypoglycemia can occur.[] High mortality (30-60%) How do patients present (clinical diagnosis) AMS Hypothermia Hypotension Respiratory Failure Hypoglycemia Hyponatremia Potential physical exam findings[] Hypoglycemia – The reduction on the metabolic rate affects the conversion of carbohydrates into glucose leading to hypoglycemia.[]

  • Wolcott-Rallison Syndrome

    The severity is variable and may lead to chronic liver dysfunction, which complicates the diabetic management with recurrent hypoglycemia due to impaired gluconeogenesis.[] Affected individuals also experience early onset pain and stiffness in affected joints (early-onset arthritis) that can develop in chronic joint pain (arthralgia) and damage[] At any age, hypoglycemia should be prevented because the disease can decompensate, even if this requires maintaining the level of glucose above the objectives generally recommended[]

  • Overlap Syndrome

    FIGURE 4 Continuous glucose monitoring shows blood glucose variability with hyper- and hypoglycemia.[] A clinical examination revealed Raynaud phenomenon, arthralgia, distal skin sclerosis, and microbleeds in the nailfold capillaries.[] Her review of systems was unremarkable, with no chronic fatigue, anorexia, abdominal pain, arthralgias or other symptoms suggestive of autoimmune disorders.[]

  • Sepsis

    This conclusion is supported by the wide variability in hypoglycemia rates reported with protocols [ 205, 206, 207, 212, 213 ].[] , and complications arising from hypoglycemia[ 5 ].[] Physical problems may include lethargy, muscle weakness, breathlessness, chest pains, oedema, arthralgia, poor appetite, visual disturbance, sensory disturbance and recurrent[]

  • Diabetes Mellitus

    Associated Complications: CNS : retinopathy, peripheral neuropathies, and autonomic neuropathy (decreased heart rate variability, orthostatic hypotension, gastroparesis,[] There have been postmarketing reports of severe and disabling arthralgia in patients taking DPP-4 inhibitors.[] The neonate did not experience hypoglycemia or other complications. Placental biopsy revealed normal findings.[]

  • Acute Lymphoblastic Leukemia Type L1

    . : Hypoglycemia and glycemic variability among children with acute lymphoblastic leukemia during maintenance therapy. Leuk Lymphoma. 2011; 52 (9): 1704–10.[] Bone pain, arthralgia, and occasionally arthritis mimic juvenile rheumatoid arthritis, rheumatic fever, other collagen diseases, or osteomyelitis.[] […] injury caused by radiotherapy and chemotherapy in patients with acute leukemia, as well as gastrointestinal toxicity caused by 5-FU, reduce the paclitaxel-related myalgia and arthralgia[]

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