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3,661 Possible Causes for Arthralgia, Immunoglobulin A Decreased, Severe Recurrent Orthostatic Hypotension

  • Amyloidosis

    Amyloidosis - primary; Immunoglobulin light chain amyloidosis; Primary systemic amyloidosis Gertz MA, Buadi FK, Lacy MQ, Hayman SR.[medlineplus.gov] Orthostatic hypotension can be severe and difficult to manage. Fitted waist-high elastic stockings and midodrine are helpful.[doi.org] […] with AL amyloidosis, but AA amyloidosis has also been reported. 39 Hepato/splenomegaly in patients with Schnitzler syndrome (IgM monoclonal gammopathy, urticarial rash, arthralgia[bloodjournal.org]

  • Primary Amyloidosis

    Low immunoglobulin levels in these patients were frequently noted and reflected decreased synthesis, urinary or gastrointestinal loss, or all of these.[annals.org] Orthostatic hypotension can be severe and difficult to manage. Fitted waist-high elastic stockings and midodrine are helpful.[doi.org] […] para-protein (IgM-κ is most common) at the dermoepidermal junction and in capillary walls which probably contributes to development of chronic urticaria, intermittent fever, arthralgia[doi.org]

  • Multiple Myeloma

    Serum concentrations of immunoglobulin G decreased and plasma cells in bone marrow decreased.[ncbi.nlm.nih.gov] The most common symptoms are joint pain (arthralgia), pain and numbness in the fingers and toes in response to cold (Raynaud’s phenomenon), weakness, and purpura.[rarediseases.org] Symptoms include fever, chills, arthralgia, myalgia, facial flushing, facial edema, vomiting, weakness, shortness of breath, hypotension, syncope, chest tightness, or angina[investors.amgen.com]

    Missing: Severe Recurrent Orthostatic Hypotension
  • Hypersensitivity

    […] and immunoglobulin E (IgE)-associated atopic dermatitis in infants and young children.[doi.org] […] antibiotics ( penicillin, amoxicillin, cefaclor, and trimethoprim-sulfamethoxazole ) Infections: Hepatitis B virus Clinical features Fever Rash ( urticarial or purpuric ) Arthralgias[amboss.com] […] life-threatening reaction that results in a systemic illness that usually includes fever and maculopapular rash accompanied by constitutional symptoms (fatigue, malaise, myalgias, and arthralgias[cid.oxfordjournals.org]

    Missing: Severe Recurrent Orthostatic Hypotension
  • Waldenstrom Macroglobulinemia

    Normal immunoglobulin synthesis is decreased, and the person is susceptible to infection, particularly bacterial pneumonia and septicemia.[healthcentral.com] A 68-year-old woman consulted for new-onset oedemas, arthralgias and purpuric lesions in lower limbs.[revistanefrologia.com] Normal immunoglobulins are decreased in half of patients.[msdmanuals.com]

    Missing: Severe Recurrent Orthostatic Hypotension
  • Precursor-Cell Lymphoblastic Leukemia

    The malignant leukemic cells are non-functional and the precursor-B cells do not produce immunoglobulins.[lecturio.com] Bone pain, arthralgia, and/or arthritis may manifest as decreased activity, general fussiness, irritability, or refusal to walk.[clinicaladvisor.com] The decreased red blood cells lead to anemia and pallor, while the decreased normal white blood cells lead to severe recurrent infections.[lecturio.com]

    Missing: Severe Recurrent Orthostatic Hypotension
  • Streptococcal Infection

    "Intravenous immunoglobulin therapy for streptococcal toxic shock syndrome—a comparative observational study. The Canadian Streptococcal Study Group".[clinicaladvisor.com] We report the case of an immunocompetent child who showed monoarticular arthritis and fever, preceded by pharyngitis and arthralgias.[ncbi.nlm.nih.gov] The minor criteria include arthralgia, fever, elevated erythrocyte sedimentation rate, elevated C-reactive protein, or a prolonged PR interval [ 1 ].[casesjournal.biomedcentral.com]

    Missing: Severe Recurrent Orthostatic Hypotension
  • Hypogammaglobulinemia

    The patient had remarkably decreased immunoglobulin levels (IgG 136 mg/dL, IgA 11 mg/dL, and IgM 10 mg/dL) 3 months after hypersensitivity to phenobarbital and phenytoin.[ncbi.nlm.nih.gov] Musculoskeletal symptoms Arthralgia and monoarticular or oligoarticular arthritis of the large joints with sterile effusions occasionally occur.[emedicine.medscape.com] Arthralgia, monoarticular or oligoarticular arthritis of the large joints with sterile effusions and septic arthritis may occur.[patient.info]

    Missing: Severe Recurrent Orthostatic Hypotension
  • Common Variable Immunodeficiency

    Diagnosis is based upon both serum immunoglobulin levels; decreased vaccine response; and exclusion of any other condition that could explain these inadequacies.[mastattack.org] Other findings less frequently reported included rash, arthralgias, myalgias, facial edema, and lymph node or liver test abnormalities, which can also occur in infectious[doi.org] Institution of appropriate therapy with immunoglobulin replacement is important to decrease risk of serious infection.[ncbi.nlm.nih.gov]

    Missing: Severe Recurrent Orthostatic Hypotension
  • Chronic Myeloid Leukemia

    Among adult patients, 15–20% may suffer from mild joint pains. 16 Arthralgia was probably the most debilitating toxicity in our patients, forcing therapy alterations.[haematologica.org] Decreased appetite 6/103 (5.83%) 6 Hyperglycaemia 6/103 (5.83%) 8 Hyperuricaemia 10/103 (9.71%) 20 Hypokalaemia 6/103 (5.83%) 7 Musculoskeletal and connective tissue disorders Arthralgia[clinicaltrials.gov] […] cardiovascular events, in particular peripheral arterial disease, was noted, although many affected patients had predisposing risk factors. 111 About 19% of all patients experience arthralgia[haematologica.org]

    Missing: Severe Recurrent Orthostatic Hypotension

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