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22 Possible Causes for Arthralgia, Immunoglobulin G Increased, Virus Associated Hemophagocytic Syndrome

  • Sickle Cell Disease

    Sickle RBCs have increased immunoglobulin G (IgG) on the cell surface.[emedicine.com]

  • Chronic Active Hepatitis

    In addition, these patients may have arthralgia, oligomenorrhea, fluctuating jaundice and cushingoid appearance with striae, hirsutism and acne.[hepatitiscentral.com] Bone marrow biopsy showed hypocellularity, histiocytic hyperplasia, and hemophagocytosis consistent with a virus-associated hemophagocytic syndrome (VAHS).[ncbi.nlm.nih.gov] Laboratory testing should show evidence of abnormal liver chemistry tests, increased total immunoglobulin G (IgG) or gamma-globulin levels and autoantibodies.[clinicaladvisor.com]

  • Autoimmune Hepatitis

    At the time of diagnosis of AIH, patients presented with arthralgia, abdominal complaints, cutaneous involvement and fatigue as common symptoms.[ncbi.nlm.nih.gov] Virus-, drug- and lymphoma-associated hemophagocytic syndrome (HPS) was ruled out. Therefore, the patient was diagnosed with autoimmune-associated HPS (AAHS).[ncbi.nlm.nih.gov] It is characterized by inflammatory liver histology, elevated transaminase level, circulating nonorgan-specific autoantibodies, and increased level of immunoglobulin G in[ncbi.nlm.nih.gov]

  • Infectious Mononucleosis

    Arthralgias and myalgias occur but are less common than in other viral infectious diseases and are rarely severe.[patient.info] Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis.[emedicine.medscape.com] Parainfluenza viruses: sudden myalgia/arthralgia with fever in mild case of tonsillitis. Diphtheria.[lecturio.com]

  • Chronic Active Hepatitis B

    In addition, these patients may have arthralgia, oligomenorrhea, fluctuating jaundice and cushingoid appearance with striae, hirsutism and acne.[hepatitiscentral.com] Bone marrow biopsy showed hypocellularity, histiocytic hyperplasia, and hemophagocytosis consistent with a virus-associated hemophagocytic syndrome (VAHS).[ncbi.nlm.nih.gov] Laboratory testing should show evidence of abnormal liver chemistry tests, increased total immunoglobulin G (IgG) or gamma-globulin levels and autoantibodies.[clinicaladvisor.com]

  • Lupus Nephritis

    Both dengue fever and SLE have common manifestations of fever, arthralgia, rash, leucopenia with thrombocytopenia and serositis.[ncbi.nlm.nih.gov] However, she suffered Epstein- Barr virus (EBV)-associated hemophagocytic syndrome (HPS) twice, and in each case she was treated with anticancer drugs and achieved a complete[ncbi.nlm.nih.gov] A 25-year-old woman presented with fever, arthralgia and proteinuria exhibiting leukopenia, hypocomplementemia, increased serum IgG and IgG4, and positive antinuclear and[ncbi.nlm.nih.gov]

  • Infectious Mononucleosis Hepatitis

    Arthralgias and myalgias occur but are less common than in other viral infectious diseases and are rarely severe.[patient.info] Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis.[emedicine.medscape.com] The presentation of “CMV syndrome” (consisting of fever, leukopenia, atypical lymphocytes, hepatomegaly, myalgia, and arthralgia) is the most common manifestation of primary[aafp.org]

  • Hepatosplenomegaly

    […] infectious and parasitic Diseases, usually do not cause difficulty in diagnosis, as they are accompanied by characteristic history, marked symptoms of intoxication, fever, arthralgia[authorstream.com] T-cell lymphoma and the virus-associated hemophagocytic syndrome. Am J Clin Pathol. 1991; 97 :189–194. [ PubMed ] 16.[ncbi.nlm.nih.gov] Relapses of thrombocytopenia with increases of platelet-associated immunoglobulin G and hepatosplenomegaly have been observed approximately every 2 months, and two relapses[ncbi.nlm.nih.gov]

  • Erythema Multiforme

    Systemic side effects of PCV13 include chills, fever, headache, vomiting, fatigue, arthralgia, myalgias, decreased appetite, and diarrhea, whereas its cutaneous adverse reactions[ncbi.nlm.nih.gov] Matsumoto YNaniwa DBanno SSugiura Y The efficacy of therapeutic plasmapheresis for the treatment of fatal hemophagocytic syndrome: two case reports.[jamanetwork.com] […] greater increase in the immunoglobulin G antibodies in paired sera tested 2 to 3 weeks apart can confirm the diagnosis.[clinicaladvisor.com]

  • Dengue Fever

    A 60-year-old Sri Lankan man presented with a history of fever, arthralgia, and generalized malaise of 2 days duration.[ncbi.nlm.nih.gov] ’s records revealed that she met the clinical case definition for hemophagocytic lymphohistiocytosis, a hyperinflammatory syndrome that is sometimes associated with dengue[emedicine.com] Collenberg et al. reported that the prevalence of antibodies against DENV determined by immunoglobulin G indirect ELISA among a sample of pregnant women and blood donors ([doi.org]

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