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3,217 Possible Causes for Arthralgia, Immunoglobulin M Decreased, Susceptibility to Hematologic Malignancies Increased

  • Common Variable Immunodeficiency

    […] serum levels of immunoglobulin G (IgG) and immunoglobulin A (IgA) are characteristic of the disorder, about 50% of CVID patients also have decreased immunoglobulin M (IgM[medigoo.com] […] to infections, autoimmune diseases, hematologic malignancy, or death caused by infection in other family members should increase the provider’s index of suspicion for CVID[mdedge.com] Other findings less frequently reported included rash, arthralgias, myalgias, facial edema, and lymph node or liver test abnormalities, which can also occur in infectious[doi.org]

  • Celiac Disease

    After three weeks she developed other symptoms such as arthralgias, malar rash, being finally diagnosed with SLE and possible autoimmune hepatitis.[ncbi.nlm.nih.gov] BACKGROUND: Familial Mediterranean fever and celiac disease share some common clinical features such as abdominal pain, diarrhea, arthralgia and arthritis.[ncbi.nlm.nih.gov] […] cutaneous vasculitis) mucosal (aphtose), hepatic (cytolysis), neurophysical (fatigue, troubles of behaviour, cerebral syndrome, neuropathy) and osteo-articulitis (osteopenia, arthralgias[ncbi.nlm.nih.gov]

    Missing: Susceptibility to Hematologic Malignancies Increased
  • Chronic Myeloid Leukemia

    Among adult patients, 15–20% may suffer from mild joint pains. 16 Arthralgia was probably the most debilitating toxicity in our patients, forcing therapy alterations.[haematologica.org] Decreased appetite 6/103 (5.83%) 6 Hyperglycaemia 6/103 (5.83%) 8 Hyperuricaemia 10/103 (9.71%) 20 Hypokalaemia 6/103 (5.83%) 7 Musculoskeletal and connective tissue disorders Arthralgia[clinicaltrials.gov] […] cardiovascular events, in particular peripheral arterial disease, was noted, although many affected patients had predisposing risk factors. 111 About 19% of all patients experience arthralgia[haematologica.org]

    Missing: Susceptibility to Hematologic Malignancies Increased
  • Amyloidosis

    […] with AL amyloidosis, but AA amyloidosis has also been reported. 39 Hepato/splenomegaly in patients with Schnitzler syndrome (IgM monoclonal gammopathy, urticarial rash, arthralgia[bloodjournal.org] Clinical features : The most frequent manifestations include cutaneous purpura and urticaria; in many cases there are weakness and arthralgias.[kidneypathology.com] Scores on the mNIS 7 and the QOL-DN showed improvement in those receiving inotersen (P 0.001). [101] Doxycycline A pilot study demonstrated reduction in arthralgia and increased[emedicine.com]

    Missing: Susceptibility to Hematologic Malignancies Increased
  • Hypogammaglobulinemia

    Serum immunoglobulin determination at Walter Reed General Hospital revealed an immunoglobulin G level of 150 mg per 100 ml and absence of immunoglobulins A and M.[pubs.rsna.org] Musculoskeletal symptoms Arthralgia and monoarticular or oligoarticular arthritis of the large joints with sterile effusions occasionally occur.[emedicine.medscape.com] Arthralgia, monoarticular or oligoarticular arthritis of the large joints with sterile effusions and septic arthritis may occur.[patient.info]

    Missing: Susceptibility to Hematologic Malignancies Increased
  • Streptococcal Infection

    (Important article describing the in vitro ability of clindamycin and linezolid to decrease superantigen toxin levels) Kaul, R, McGeer, A, Norrby-Teglund, A, Kotb, M, Schwartz[clinicaladvisor.com] We report the case of an immunocompetent child who showed monoarticular arthritis and fever, preceded by pharyngitis and arthralgias.[ncbi.nlm.nih.gov] The minor criteria include arthralgia, fever, elevated erythrocyte sedimentation rate, elevated C-reactive protein, or a prolonged PR interval [ 1 ].[casesjournal.biomedcentral.com]

    Missing: Susceptibility to Hematologic Malignancies Increased
  • Rheumatoid Arthritis

    At that point, hepatitis E virus (HEV) infection was diagnosed with a positive anti-HEV immunoglobulin M (IgM) antibody and HEV-ribonucleotide acid (RNA) of 6280 copies/mL[ncbi.nlm.nih.gov] It can cause arthralgias and weakness in intrinsic muscles of the hand.[ncbi.nlm.nih.gov] Six weeks later, along with steroid dose reduction, the symptoms of arthralgia was observed, which was managed with methotrexate.[ncbi.nlm.nih.gov]

    Missing: Susceptibility to Hematologic Malignancies Increased
  • Malignant Melanoma

    Common adverse events associated with vemurafenib were arthralgia, rash, fatigue, alopecia, keratoacanthoma or squamous-cell carcinoma, photosensitivity, nausea, and diarrhea[ncbi.nlm.nih.gov] Overall, BRAF inhibitors were well tolerated; common adverse events are arthralgia, rash, fatigue, alopecia, keratoacanthoma or cutaneous squamous-cell carcinoma, photosensitivity[ncbi.nlm.nih.gov] Eight patients (22.9%) had AEs leading to discontinuation of study drug; the most common AEs were arthralgia and myalgia (5.7% each).[doi.org]

    Missing: Susceptibility to Hematologic Malignancies Increased
  • Nephrotic Syndrome

    Six weeks later, along with steroid dose reduction, the symptoms of arthralgia was observed, which was managed with methotrexate.[ncbi.nlm.nih.gov] Fluid retention may cause Dyspnea (pleural effusion or laryngeal edema) Arthralgia (hydrarthrosis) Abdominal pain (ascites or, in children, mesenteric edema) Corresponding[merckmanuals.com]

    Missing: Susceptibility to Hematologic Malignancies Increased
  • Multiple Myeloma

    Targeted therapy : Targeted therapy with proteasome inhibitors is given to decrease how much immunoglobulin M is in the blood and treat amyloidosis.[cancer.gov] The most common symptoms are joint pain (arthralgia), pain and numbness in the fingers and toes in response to cold (Raynaud’s phenomenon), weakness, and purpura.[rarediseases.org] The amount of normal immunoglobulins in the sample may be visibly decreased as well.[labtestsonline.org]

    Missing: Susceptibility to Hematologic Malignancies Increased

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