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1,584 Possible Causes for Arthralgia, Knee Pain, Malaise, Proteinuria

  • Muckle Wells Syndrome

    The term Muckle-Wells syndrome (MWS) describes an autosomal dominant disorder characterised by various combinations of urticaria, sensorineural deafness, amyloidosis, arthralgia[ncbi.nlm.nih.gov] Even my husband wasn't understanding our sons battle with itching and knee pain. I was told Kids just get these things and since it goes away don't worry.[rareconnect.org] Muckle-Wells syndrome (MWS) is a rare syndrome, characterized by chronic recurrent urticaria, often combined with fever, chills, rigors, malaise, and arthralgia.[ncbi.nlm.nih.gov] Renal involvement, in terms of proteinuria or renal insufficiency, can be observed in up to 25% of patients.[ncbi.nlm.nih.gov]

  • Kawasaki Disease

    However, his fever and arthralgia persisted. He was administered single 5 mg/kg doses of IFX. He became afebrile the next day and his arthralgia improved.[ncbi.nlm.nih.gov] The specific signs and symptoms vary with the stage of disease: Acute stage fever that is refractory to antibiotics general malaise and irritability non-exudative conjunctivitis[radiopaedia.org] Urinalysis may show sterile pyuria proteinuria.[patient.info] We report the case of a 26-year-old paediatric resident with fever, exanthema, ocular changes, arthralgia, and desquamation of palms and soles.[ncbi.nlm.nih.gov]

  • Rheumatic Fever

    High ASO titers, arthralgia, and combination of high ASO titers with arthralgia are the main presenting symptoms in the group with a different diagnosis.[ncbi.nlm.nih.gov] They may include: Fever Painful and tender joints, most often the ankles, knees, elbows or wrists Pain that moves from joint to joint Red, hot or swollen joints Small, painless[arthritis.org] There is sudden onset of fever, joint pain, malaise and loss of appetite. In some cases, epistaxis and abdominal pain may also be present.[symptoma.com] Affected individuals may also develop leukocytosis, moderate anemia, and proteinuria.[medical-dictionary.thefreedictionary.com]

  • Lyme Disease

    In a second case, a 40-year-old male, with a previously known microscopic hematuria, presented with rash, arthralgias, new proteinuria and gross hematuria following a tick[ncbi.nlm.nih.gov] Knee pain may be a symptom of advanced Lyme disease. Image Source: Image reprinted with permission from eMedicine.com, 2008.[emedicinehealth.com] Here, we report a 63-year-old American man living in Japan who presented with malaise, headache, myalgia, and arthralgia.[ncbi.nlm.nih.gov] From 90 days before the diagnosis, malaise and fatigue (OR, 1.7; 95% CI, 1.1-2.6; p   0.05), other nervous system disorders (OR, 2.0; 95% CI, 1.3-3.1; p   0.01), and nontraumatic[ncbi.nlm.nih.gov]

  • Polymyalgia Rheumatica

    The systemic inflammatory systems of WG, including arthralgias, may mimic other conditions such as PMR.[ncbi.nlm.nih.gov] Over the next few days I started getting pain in other knee and hip.[medicinenet.com] […] triple immunosuppressive therapy (which includes tacrolimus, mycophenolate mofetil, and prednisone) for a renal transplant that she had received 10 years ago presented with malaise[ncbi.nlm.nih.gov] We present a case of a patient with history PMR who developed nephrotic range proteinuria and rapidly deteriorating renal function secondary to AA amyloidosis within 18 months[ncbi.nlm.nih.gov]

  • Pyoderma Gangrenosum

    PG patients with IBD had increased occurrence rates of arthralgia or arthritis, anemia, and ANCA-positive status compared to idiopathic PG patients.[ncbi.nlm.nih.gov] Study Persistent Pain After Total Knee Replacement Study Rotator Cuff Stem Cell Clinical Trial Treatment Study for Articular Cartilage Injuries in the Knee Pain Management[rush.edu] Although PSPG can demonstrate fever, malaise, systemic signs, and serology that mimic the sepsis of necrotizing fasciitis, we identify some features that can aid diagnosis[ncbi.nlm.nih.gov] Other less commonly associated features include adult-onset insulin-dependent diabetes mellitus, proteinuria, and abscess formation at the site of parenteral injections (pathergy[orpha.net]

  • Granulomatosis with Polyangiitis

    We report this case that presented with a productive cough, followed by arthralgia, DAH, and GIH.[ncbi.nlm.nih.gov] Joint pain also is a symptom of Wegener's granulomatosis. Pain within the joint is a common cause of shoulder pain, ankle pain, and knee pain.[medicinenet.com] […] considered when patients do not improve despite adequate treatment of otologic symptoms, when patients have unspecific symptoms suggesting systemic disease (e.g. fever, malaise[ncbi.nlm.nih.gov] Renal involvement Focal lesions can give proteinuria and haematuria while diffuse lesions can give acute renal failure.[radiopaedia.org]

  • Q Fever

    The most frequent clinical manifestation of acute form is a self-limited febrile illness which is associated with severe headache, muscle ache, arthralgia and cough.[ncbi.nlm.nih.gov] Here we present a 41-year-old male complaining of body ache, fever, nausea, malaise, bilateral knee pain and vomiting.[ncbi.nlm.nih.gov] Clinical symptoms were nonspecific: myalgia (94%), fever (91%), headache (80%), acute fatigue (64%), and arthralgia (55%).[ncbi.nlm.nih.gov] We report the case of a 36-year-old woman from Iraq who presented with long-standing malaise as well as vague chest and shoulder discomfort and was found to have a saccular[ncbi.nlm.nih.gov]

  • Lead Poisoning

    Both patients exhibited colic, arthralgia, and anemia. Blood lead levels were 73.1 microg/dl and 96.3 microg/dl.[ncbi.nlm.nih.gov] A 28-year-old man suffered from chronic bilateral knee pain accompanied by muscle fibrillations and night cramps.[ncbi.nlm.nih.gov] […] poisoning was discovered in the third trimester in 12 (86%) subjects after the women presented with subtle but characteristic findings of severe lead poisoning, including malaise[ncbi.nlm.nih.gov] During the regular follow-up, renal function remained stable with no proteinuria.[ncbi.nlm.nih.gov]

  • Rheumatoid Arthritis

    However, arthralgia of the bilateral knees developed in March 2015.[ncbi.nlm.nih.gov] Knee and hip replacements are most common. The effects of surgery can help to ease pain and regain joint movement.[familydoctor.org] A 66-year-old man with seronegative, erosive rheumatoid arthritis for 12 years presented with malaise, elevated alkaline phosphatase and gamma-glutamyl transferase, and leg[ncbi.nlm.nih.gov] Her urine full report revealed 2 proteinuria with active sediment (dysmorphic red blood cells [17%] and granular casts). Her 24-hour urinary protein excretion was 2 g.[ncbi.nlm.nih.gov]

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