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4,139 Possible Causes for Arthralgia, Leg Edema, Severe Recurrent Orthostatic Hypotension

  • Amyloidosis

    Orthostatic hypotension can be severe and difficult to manage. Fitted waist-high elastic stockings and midodrine are helpful.[doi.org] […] with AL amyloidosis, but AA amyloidosis has also been reported. 39 Hepato/splenomegaly in patients with Schnitzler syndrome (IgM monoclonal gammopathy, urticarial rash, arthralgia[bloodjournal.org] Patients may experience symptoms such as foamy urine or leg edema.[nyp.org]

  • Temporal Arteritis

    […] ophthalmic artery and its branches are affected, is characterized by the formation of giant cells, and may be accompanied by fever, malaise, fatigue, anorexia, weight loss, and arthralgia[merriam-webster.com] In NAION, patients will usually not note any associated systemic symptoms such as headache, jaw claudication, scalp tenderness, weight loss, anorexia, fever, or myalgias/arthralgias[eyewiki.aao.org]

    Missing: Severe Recurrent Orthostatic Hypotension
  • Primary Amyloidosis

    Orthostatic hypotension can be severe and difficult to manage. Fitted waist-high elastic stockings and midodrine are helpful.[doi.org] […] para-protein (IgM-κ is most common) at the dermoepidermal junction and in capillary walls which probably contributes to development of chronic urticaria, intermittent fever, arthralgia[doi.org] This may result in a condition called nephrotic syndrome, where there is excess protein in the urine and the lower legs can become swollen (also called “edema”).[amyloidosis.org]

  • Systemic Amyloidosis

    recurrent inflammation. 57 Supportive treatment of specific symptoms Although symptoms of dysautonomia are rare in AA amyloidosis, severe orthostatic hypotension may lead[ncbi.nlm.nih.gov] […] para-protein (IgM-κ is most common) at the dermoepidermal junction and in capillary walls which probably contributes to development of chronic urticaria, intermittent fever, arthralgia[doi.org] During this observation period, the level of IgE gradually increased and, at 2 years after the initial diagnosis, bilateral leg edema and ascites with marked hepatosplenomegaly[ncbi.nlm.nih.gov]

  • Acute Nephritis

    The disease started with arthralgia, headache, fever, malaise, and lymphadenopathy. During the following 2 weeks, signs of mild nephritis developed.[ncbi.nlm.nih.gov] Swelling facial swelling swelling around the eye socket arms, hands, feet, legs ( dependent edema ) abdomen generalized General aches and pains ( joint pain, muscle aches[medical-dictionary-search-engines.com] […] article on Rash and acute nephritic syndrome due to candesartan by Morton et al. [1] Their patient was 73 years old, and showed non-palpable purpura, no abdominal pain or arthralgia[bmj.com]

    Missing: Severe Recurrent Orthostatic Hypotension
  • Acute Renal Failure

    In about one-third of cases, there is a history of maculopapular erythematous rash, fever, arthralgias, or a combination of these symptoms. 13 Eosinophiluria may be found[aafp.org] Arms and legs (extremities). The physican and nursing staff will check the patients arms and legs for edema at the time of diagnosis and throughout treatment.[encyclopedia.com] Features of underlying systemic disease (rashes, arthralgia).[patient.info]

    Missing: Severe Recurrent Orthostatic Hypotension
  • Gouty Arthritis

    Common AEs included back pain, headache, hypertension, arthralgia and gamma‐glutamyl transferase increase.[doi.org] Gout Triggers Medical or health triggers of gout: Joint injury Surgery or sudden, severe illness Infection Taking certain diuretic medications for high blood pressure, leg[arthritis.org] […] swelling (edema) or heart failure Taking the drug cyclosporine Starting a uric acid-lowering treatment Chemotherapy Lifestyle triggers of gout: Crash diets and fasting Drinking[arthritis.org]

    Missing: Severe Recurrent Orthostatic Hypotension
  • Polyarthritis

    Although bisphosphonates are safety drugs, they have numerous side-effects such as arthralgia, elevated erythrocyte sedimentation rate and C-reactive protein, gastrointestinal[ncbi.nlm.nih.gov] Marked erythema and edema of the MCP and metatarsophalangeal joints (Figure 2) and bilateral ankles were observed.[mdedge.com] Alphavirus Polyarthritis Syndrome has an incubation period of 3–21 days, depending on the specific virus, with either a gradual or sudden onset of fever, arthralgias, headache[en.wikipedia.org]

    Missing: Severe Recurrent Orthostatic Hypotension
  • Pneumonia

    Arthralgia and myalgia are often reported. Severe complications include pancreatitis, peritonitis, pericarditis, myocarditis, endocarditis and glomerulonephritis.[patient.info] (swelling of the legs, in general, of the "pitting" variety, wherein the skin is slow to return to normal when pressed upon), raised jugular venous pressure and hepatomegaly[en.wikipedia.org] Adverse effects Number and seriousness of adverse effects, including cases of malaise, nausea, fever, arthralgias, rash, headache and more generalised and serious signs.[doi.org]

    Missing: Severe Recurrent Orthostatic Hypotension
  • Biliary Cirrhosis

    Europe & North American Presentation – heterogeneous Variable – no symptoms/signs to fulminant hepatic failure Malaise, anorexia, nausea, vomiting, abdominal pain, itching Arthralgia[slideshare.net] (edema) and in the abdomen (ascites) Yellow color in the skin, mucous membranes, or eyes (jaundice) Redness on the palms of the hands In men, impotence, shrinking of the[medlineplus.gov] A trial of corticosteroids in patients with idiopathic granulomatous hepatitis who are symptomatic, with fever, myalgias, and arthralgias, may be helpful.[clevelandclinicmeded.com]

    Missing: Severe Recurrent Orthostatic Hypotension

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