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10 Possible Causes for Arthralgia, Pleural Effusion, Severe Recurrent Orthostatic Hypotension

  • Amyloidosis

    Orthostatic hypotension can be severe and difficult to manage. Fitted waist-high elastic stockings and midodrine are helpful.[doi.org] […] with AL amyloidosis, but AA amyloidosis has also been reported. 39 Hepato/splenomegaly in patients with Schnitzler syndrome (IgM monoclonal gammopathy, urticarial rash, arthralgia[bloodjournal.org] KEYWORDS: Congo red; amyloidosis; pleural effusion[ncbi.nlm.nih.gov]

  • Primary Amyloidosis

    Orthostatic hypotension can be severe and difficult to manage. Fitted waist-high elastic stockings and midodrine are helpful.[doi.org] […] para-protein (IgM-κ is most common) at the dermoepidermal junction and in capillary walls which probably contributes to development of chronic urticaria, intermittent fever, arthralgia[doi.org] A chest X-ray showed right-sided moderate pleural effusion. A thoracocentesis revealed an exudative pleural effusion.[ncbi.nlm.nih.gov]

  • Capillary Leak Syndrome

    . - A man aged 61 had recurrent attacks of severe shock.[ntvg.nl] The most common side effects of IL-11 are arthralgias and myalgias, fatigue, nausea, and headache.[cancerjournal.net] Besides fever, body ache and bleeding manifestations, ascites was present in 84% cases, pleural effusion in 76% cases, and both ascites and pleural effusion in 60% of cases[who.int]

  • Systemic Amyloidosis

    recurrent inflammation. 57 Supportive treatment of specific symptoms Although symptoms of dysautonomia are rare in AA amyloidosis, severe orthostatic hypotension may lead[ncbi.nlm.nih.gov] […] para-protein (IgM-κ is most common) at the dermoepidermal junction and in capillary walls which probably contributes to development of chronic urticaria, intermittent fever, arthralgia[doi.org] Thus, despite a lack of biopsy-proven amyloid deposition, we suggest that these effusions may be secondary to pleural amyloid deposition.[ncbi.nlm.nih.gov]

  • Optic Nerve Edema-Splenomegaly Syndrome

    Complications such as severe orthostatic hypotension, recurrent infections or venous thromboses should be evaluated on the basis of resultant impairment. C.[secure.ssa.gov] Ankle arthralgias are common.[autoinflammatory-search.org] Additional symptoms associated with POEMS syndrome include fluid buildup in the lungs (pleural effusion), and abnormal accumulation of fluid in the skin of the arms and legs[rarediseases.org]

  • Acute Pandysautonomia

    Patient 6 had a history of recurrent ileus and severe abdominal pain.[journals.plos.org] Additional features of the cryoglobulinemic syndrome include purpura, skin ulcers, arthralgias, sicca syndrome, Raynaud’s phenomenon, glomerulonephritis, and lymphadenopathy[mjhid.org] Illustrative cases Patient 1: A 75-year-old man who had been affected by AAG for at least 15 years and who had severe orthostatic hypotension (supine, 102/64 mmHg; sitting[journals.plos.org]

  • Autosomal Dominant Hereditary Sensory and Autonomic Neuropathy

    Severe autonomic dysfunctions occur: alacrymia (loss of tear secretion), dysphagia, hypothermia, orthostatic hypotension, loss of fungiform papillas on tongue.[tankonyvtar.hu] […] for 3/12 in four or more joints Minor criteria Current/historic Brighton score of 1, 2 or 3/9 (0, 1, 2, 3/9 if 50 years old) Arthralgia for minimum of 3 months in 1–3 joints[medical-dictionary.thefreedictionary.com] There are appropriate responses to pleural effusions, esophageal irritation, and menstrual cramping.[ojrd.biomedcentral.com]

  • Familial Dysautonomia

    The latter leads to severe hypotension and may later trigger syncopes due to orthostatic hypotension.[symptoma.com] […] for 3/12 in four or more joints Minor criteria Current/historic Brighton score of 1, 2 or 3/9 (0, 1, 2, 3/9 if 50 years old) Arthralgia for minimum of 3 months in 1–3 joints[medical-dictionary.thefreedictionary.com] There are appropriate responses to pleural effusions, esophageal irritation, and menstrual cramping.[doi.org]

  • Antineoplastic Agent

    Multiple myeloma, erythema nodosum leprosum and the following orphan indications: graft versus host disease, mycobacterial infection, recurrent aphthous ulcers, severe recurrent[en.wikipedia.org] Other adverse effects included myalgias, arthralgias, alopecia, diarrhea, nausea, vomiting, mucositis, and peripheral neuropathy.[ncbi.nlm.nih.gov] Rare side-effects include pleural effusions and diffuse alveolar damage or ARDS.[annonc.oxfordjournals.org]

  • Fentanyl

    Severe Hypotension: ACTIQ may cause severe hypotension including orthostatic hypotension and syncope in ambulatory patients.[actiq.com] […] reported: abnormal healing, dehydration [ Ref ] Endocrine Uncommon (0.1% to 1%): Hot flush [ Ref ] Musculoskeletal Common (1% to 10%): Fall/accidental injury, back pain, arthralgia[web.archive.org] Effusions / Pleural Diseases / Pleural Effusions 1 Not Available RecruitingTreatment Nausea / Pain NOS 1 Not Available RecruitingTreatment Post Laparotomy Pain Treatment[drugbank.ca]

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