Create issue ticket

11 Possible Causes for Arthralgia, Progressive Polyneuropathy, Severe Recurrent Orthostatic Hypotension

  • Amyloidosis

    Tafamidis is a TTR stabilizer that is orally administered and, by interfering with amyloid fibril formation and deposition, is capable of slowing progression of TTR polyneuropathy[ncbi.nlm.nih.gov] Orthostatic hypotension can be severe and difficult to manage. Fitted waist-high elastic stockings and midodrine are helpful.[doi.org] […] with AL amyloidosis, but AA amyloidosis has also been reported. 39 Hepato/splenomegaly in patients with Schnitzler syndrome (IgM monoclonal gammopathy, urticarial rash, arthralgia[bloodjournal.org]

  • Primary Amyloidosis

    Hou X, Aguilar MI, Small DH (2007) Transthyretin and familial amyloidotic polyneuropathy. Recent progress in understanding the molecular mechanism of neurodegeneration.[doi.org] Orthostatic hypotension can be severe and difficult to manage. Fitted waist-high elastic stockings and midodrine are helpful.[doi.org] […] para-protein (IgM-κ is most common) at the dermoepidermal junction and in capillary walls which probably contributes to development of chronic urticaria, intermittent fever, arthralgia[doi.org]

  • Systemic Amyloidosis

    Hou X, Aguilar MI, Small DH (2007) Transthyretin and familial amyloidotic polyneuropathy. Recent progress in understanding the molecular mechanism of neurodegeneration.[doi.org] recurrent inflammation. 57 Supportive treatment of specific symptoms Although symptoms of dysautonomia are rare in AA amyloidosis, severe orthostatic hypotension may lead[ncbi.nlm.nih.gov] […] para-protein (IgM-κ is most common) at the dermoepidermal junction and in capillary walls which probably contributes to development of chronic urticaria, intermittent fever, arthralgia[doi.org]

  • Acute Pandysautonomia

    The serial electrophysiologic studies revealed progressive periphear axonal polyneuropathy.[jkna.org] Patient 6 had a history of recurrent ileus and severe abdominal pain.[journals.plos.org] Additional features of the cryoglobulinemic syndrome include purpura, skin ulcers, arthralgias, sicca syndrome, Raynaud’s phenomenon, glomerulonephritis, and lymphadenopathy[mjhid.org]

  • Dysautonomia

    MNGIE is characterized by the association of progressive external ophthalmoplegia (PEO), myopathy, polyneuropathy and leukoencephalopathy.[tankonyvtar.hu] […] rapid heartbeat (tachycardia), excessive sweating (hyperhidrosis), perspiration depletion (anhidrosis), nerve pain or numbness (paresthesia or neuropathy), and joint pain (arthralgia[clinicalposters.com] Severe autonomic dysfunctions occur: alacrymia (loss of tear secretion), dysphagia, hypothermia, orthostatic hypotension, loss of fungiform papillas on tongue.[tankonyvtar.hu]

  • Pure Autonomic Failure

    This progressive neurological disease is very debilitating and can eventually lead to respiratory failure.[njfaint.com] First, patients with PAF did not have severe urinary disturbances, which would lessen the risk of recurrent urinary infections, and they also did not have life threatening[jnnp.bmj.com] […] foreign body in the eye, increased lacrimation (tear production), blepharitis (inflammation of the eyelids), dry eye, ocular hyperaemia (red eye), eye pruritis (itching), arthralgia[sv.glosbe.com]

  • Autosomal Dominant Hereditary Sensory and Autonomic Neuropathy

    […] and signs progress.[clevelandclinicmeded.com] Severe autonomic dysfunctions occur: alacrymia (loss of tear secretion), dysphagia, hypothermia, orthostatic hypotension, loss of fungiform papillas on tongue.[tankonyvtar.hu] […] for 3/12 in four or more joints Minor criteria Current/historic Brighton score of 1, 2 or 3/9 (0, 1, 2, 3/9 if 50 years old) Arthralgia for minimum of 3 months in 1–3 joints[medical-dictionary.thefreedictionary.com]

  • Familial Dysautonomia

    Abstract Familial dysautonomia (FD) is a devastating developmental and progressive peripheral neuropathy caused by a mutation in the gene inhibitor of kappa B kinase complex-associated[pnas.org] The latter leads to severe hypotension and may later trigger syncopes due to orthostatic hypotension.[symptoma.com] […] for 3/12 in four or more joints Minor criteria Current/historic Brighton score of 1, 2 or 3/9 (0, 1, 2, 3/9 if 50 years old) Arthralgia for minimum of 3 months in 1–3 joints[medical-dictionary.thefreedictionary.com]

  • Optic Nerve Edema-Splenomegaly Syndrome

    […] and signs progress.[clevelandclinicmeded.com] Complications such as severe orthostatic hypotension, recurrent infections or venous thromboses should be evaluated on the basis of resultant impairment. C.[secure.ssa.gov] Ankle arthralgias are common.[autoinflammatory-search.org]

  • Kappa Chain Deficiency

    Glycoconjugate antigens, both glycoproteins and glycolipids, have been identified as putative targets for many of these autoimmune polyneuropathies.[questdiagnostics.com] Orthostatic hypotension can be severe and difficult to manage. Fitted waist-high elastic stockings and midodrine are helpful.[cjasn.asnjournals.org] Arthralgia and conjunctivitis are frequently reported. Pyoderma, urinary tract infection, osteomyelitis/arthritis, and meningitis/encephalitis are less common.[emedicine.medscape.com]

Similar symptoms