Create issue ticket

16 Possible Causes for Arthralgia, Severe Recurrent Orthostatic Hypotension

  • Amyloidosis

    Orthostatic hypotension can be severe and difficult to manage. Fitted waist-high elastic stockings and midodrine are helpful.[doi.org] […] with AL amyloidosis, but AA amyloidosis has also been reported. 39 Hepato/splenomegaly in patients with Schnitzler syndrome (IgM monoclonal gammopathy, urticarial rash, arthralgia[bloodjournal.org] Clinical features : The most frequent manifestations include cutaneous purpura and urticaria; in many cases there are weakness and arthralgias.[kidneypathology.com]

  • Primary Amyloidosis

    Orthostatic hypotension can be severe and difficult to manage. Fitted waist-high elastic stockings and midodrine are helpful.[doi.org] […] para-protein (IgM-κ is most common) at the dermoepidermal junction and in capillary walls which probably contributes to development of chronic urticaria, intermittent fever, arthralgia[doi.org] […] with AL amyloidosis, but AA amyloidosis has also been reported. 39 Hepato/splenomegaly in patients with Schnitzler syndrome (IgM monoclonal gammopathy, urticarial rash, arthralgia[bloodjournal.org]

  • Capillary Leak Syndrome

    . - A man aged 61 had recurrent attacks of severe shock.[ntvg.nl] The most common side effects of IL-11 are arthralgias and myalgias, fatigue, nausea, and headache.[cancerjournal.net] And as this progresses, patients develop myalgias and arthralgias, muscle aches and bone and joint aching that really has been quite severe in some cases.[ajmc.com]

  • Dysautonomia

    Severe autonomic dysfunctions occur: alacrymia (loss of tear secretion), dysphagia, hypothermia, orthostatic hypotension, loss of fungiform papillas on tongue.[tankonyvtar.hu] […] rapid heartbeat (tachycardia), excessive sweating (hyperhidrosis), perspiration depletion (anhidrosis), nerve pain or numbness (paresthesia or neuropathy), and joint pain (arthralgia[clinicalposters.com] Gastroesophageal reflux, vomiting or recurrent pneumonia indicate gastrointestinal dysfunction. Sensory loss is mild; scoliosis frequently develops (85%). 2.4.[tankonyvtar.hu]

  • Acute Pandysautonomia

    Patient 6 had a history of recurrent ileus and severe abdominal pain.[journals.plos.org] Additional features of the cryoglobulinemic syndrome include purpura, skin ulcers, arthralgias, sicca syndrome, Raynaud’s phenomenon, glomerulonephritis, and lymphadenopathy[mjhid.org] Illustrative cases Patient 1: A 75-year-old man who had been affected by AAG for at least 15 years and who had severe orthostatic hypotension (supine, 102/64 mmHg; sitting[journals.plos.org]

  • Idiopathic Bilateral Vestibulopathy

    Patients most often experience BPPV when lying down, which distinguishes BPPV from orthostatic hypotension. In addition, BPPV may be recurrent.[raleighcapitolent.com] […] purpura: With vasculitis, cutaneous or systemic Thymus hyperplasia Vasculopathies, other: Raynaud's (30%) Parotid swelling: Especially younger patients Discomfort: Myalgias ; Arthralgias[neuromuscular.wustl.edu] Both the vertigo and nystagmus tend to be less severe when the movement is repeated.[raleighcapitolent.com]

  • Pure Autonomic Failure

    First, patients with PAF did not have severe urinary disturbances, which would lessen the risk of recurrent urinary infections, and they also did not have life threatening[jnnp.bmj.com] […] rapid heartbeat (tachycardia), excessive sweating (hyperhidrosis), perspiration depletion (anhidrosis), nerve pain or numbness (paresthesia or neuropathy), and joint pain (arthralgia[clinicalposters.com] Second, while management of orthostatic hypotension remains challenging late in the course of illness, administration of plasma volume expansion fluids, fludrocortisone, and[jnnp.bmj.com]

  • Systemic Amyloidosis

    recurrent inflammation. 57 Supportive treatment of specific symptoms Although symptoms of dysautonomia are rare in AA amyloidosis, severe orthostatic hypotension may lead[ncbi.nlm.nih.gov] […] para-protein (IgM-κ is most common) at the dermoepidermal junction and in capillary walls which probably contributes to development of chronic urticaria, intermittent fever, arthralgia[doi.org] […] with AL amyloidosis, but AA amyloidosis has also been reported. 39 Hepato/splenomegaly in patients with Schnitzler syndrome (IgM monoclonal gammopathy, urticarial rash, arthralgia[bloodjournal.org]

  • Autosomal Dominant Hereditary Sensory and Autonomic Neuropathy

    Severe autonomic dysfunctions occur: alacrymia (loss of tear secretion), dysphagia, hypothermia, orthostatic hypotension, loss of fungiform papillas on tongue.[tankonyvtar.hu] […] for 3/12 in four or more joints Minor criteria Current/historic Brighton score of 1, 2 or 3/9 (0, 1, 2, 3/9 if 50 years old) Arthralgia for minimum of 3 months in 1–3 joints[medical-dictionary.thefreedictionary.com] Gastroesophageal reflux, vomiting or recurrent pneumonia indicate gastrointestinal dysfunction. Sensory loss is mild; scoliosis frequently develops (85%). 2.4.[tankonyvtar.hu]

  • Familial Dysautonomia

    The latter leads to severe hypotension and may later trigger syncopes due to orthostatic hypotension.[symptoma.com] […] for 3/12 in four or more joints Minor criteria Current/historic Brighton score of 1, 2 or 3/9 (0, 1, 2, 3/9 if 50 years old) Arthralgia for minimum of 3 months in 1–3 joints[medical-dictionary.thefreedictionary.com] ) and gastrostomy tube placement; labile BP with orthostatic hypotension, supine hypertension, and several hypertensive crises per week; syncopal episodes necessitating pacemaker[cjasn.asnjournals.org]

Further symptoms

Similar symptoms