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10 Possible Causes for Arthralgia, Severe Recurrent Orthostatic Hypotension, Skin Biopsy Abnormal

  • Amyloidosis

    Orthostatic hypotension can be severe and difficult to manage. Fitted waist-high elastic stockings and midodrine are helpful.[doi.org] Organ Biopsy If amyloidosis is still suspected but biopsies of the bone marrow, fat pad, lip or skin sites turn up negative, then a surgical biopsy of the organ that is indicating[amyloidosis.org] […] with AL amyloidosis, but AA amyloidosis has also been reported. 39 Hepato/splenomegaly in patients with Schnitzler syndrome (IgM monoclonal gammopathy, urticarial rash, arthralgia[bloodjournal.org]

  • Primary Amyloidosis

    Orthostatic hypotension can be severe and difficult to manage. Fitted waist-high elastic stockings and midodrine are helpful.[doi.org] […] in human tissue.2 Skin biopsy with ultrastructural immunohistochemical stains can be a tool to determine the clinical type of amyloidosis by detecting the subtype of amyloid[mdedge.com] […] para-protein (IgM-κ is most common) at the dermoepidermal junction and in capillary walls which probably contributes to development of chronic urticaria, intermittent fever, arthralgia[doi.org]

  • Systemic Amyloidosis

    recurrent inflammation. 57 Supportive treatment of specific symptoms Although symptoms of dysautonomia are rare in AA amyloidosis, severe orthostatic hypotension may lead[ncbi.nlm.nih.gov] A local skin biopsy showed amorphous and eosinophilic substance in the dermis. Congo red staining confirmed the amyloid deposits.[ncbi.nlm.nih.gov] […] para-protein (IgM-κ is most common) at the dermoepidermal junction and in capillary walls which probably contributes to development of chronic urticaria, intermittent fever, arthralgia[doi.org]

  • Acute Pandysautonomia

    Patient 6 had a history of recurrent ileus and severe abdominal pain.[journals.plos.org] As distal endings are primarily involved in distal axonopathy forms of neuropathy, skin biopsy may be more sensitive than sural nerve biopsy to detect early abnormalities.[ihpotblogspot.blogspot.com] Additional features of the cryoglobulinemic syndrome include purpura, skin ulcers, arthralgias, sicca syndrome, Raynaud’s phenomenon, glomerulonephritis, and lymphadenopathy[mjhid.org]

  • Pure Autonomic Failure

    First, patients with PAF did not have severe urinary disturbances, which would lessen the risk of recurrent urinary infections, and they also did not have life threatening[jnnp.bmj.com] Skin biopsy showed involvement of somatic epidermal unmyelinated nerve fibers. Quantitative sensory testing showed abnormal thresholds to all thermal modalities.[ncbi.nlm.nih.gov] […] foreign body in the eye, increased lacrimation (tear production), blepharitis (inflammation of the eyelids), dry eye, ocular hyperaemia (red eye), eye pruritis (itching), arthralgia[sv.glosbe.com]

  • Idiopathic Bilateral Vestibulopathy

    Patients most often experience BPPV when lying down, which distinguishes BPPV from orthostatic hypotension. In addition, BPPV may be recurrent.[raleighcapitolent.com] biopsy: Non length dependent loss of small axons Abnormal glucose tolerance: 23% Nerve conduction studies Usually normal Reduced SNAP amplitude in some patients Treatment[neuromuscular.wustl.edu] Both the vertigo and nystagmus tend to be less severe when the movement is repeated.[raleighcapitolent.com]

  • Autosomal Dominant Hereditary Sensory and Autonomic Neuropathy

    Severe autonomic dysfunctions occur: alacrymia (loss of tear secretion), dysphagia, hypothermia, orthostatic hypotension, loss of fungiform papillas on tongue.[tankonyvtar.hu] […] tests to detect abnormalities in sweat production Pain and temperature tests Nerve biopsy to determine myelin levels and nerve cell deterioration: A nerve biopsy is performed[dovemed.com] […] for 3/12 in four or more joints Minor criteria Current/historic Brighton score of 1, 2 or 3/9 (0, 1, 2, 3/9 if 50 years old) Arthralgia for minimum of 3 months in 1–3 joints[medical-dictionary.thefreedictionary.com]

  • Familial Dysautonomia

    The latter leads to severe hypotension and may later trigger syncopes due to orthostatic hypotension.[symptoma.com] […] was reduced in skin biopsies from calf and back of FD patients (Hilz et al 19 and personal communication), corresponding to the reduction of sympathetic ganglia at the spinal[jnnp.bmj.com] […] for 3/12 in four or more joints Minor criteria Current/historic Brighton score of 1, 2 or 3/9 (0, 1, 2, 3/9 if 50 years old) Arthralgia for minimum of 3 months in 1–3 joints[medical-dictionary.thefreedictionary.com]

  • Optic Nerve Edema-Splenomegaly Syndrome

    Complications such as severe orthostatic hypotension, recurrent infections or venous thromboses should be evaluated on the basis of resultant impairment. C.[secure.ssa.gov] Spasticity, dystonia of the limbs or hypotonia of the trunk noted. [104] Vasculitis in the small vessels noted on skin biopsy of distal lesions from chilblains. [106] Not[autoinflammatory-search.org] Insidious with arthralgia. Colicky, diarrhoea and wt loss. Cerebrohepatorenal syndrome. AR Rare disorder of absent peroxisomes. Zollinger-Ellison syndrome Gastrinoma.[quizlet.com]

  • Autosomal Dominant Mental Retardation Type 5

    Observation of severe orthostatic hypotension in a patient whose plasma norepinephrine/dopamine ratio is much less than one supports the diagnosis.[massgeneral.org] The retinal and neurologic features may have been secondary to nutritional abnormalities.[findzebra.com] The hypotension can be so severe as to lead to convulsive syncope with recurrent clonic seizures. Most patients reported to date have been identified as young adults.[massgeneral.org]

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