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10 Possible Causes for Arthralgia, Severe Recurrent Orthostatic Hypotension, X-Ray Abnormal

  • Amyloidosis

    Orthostatic hypotension can be severe and difficult to manage. Fitted waist-high elastic stockings and midodrine are helpful.[doi.org] […] with AL amyloidosis, but AA amyloidosis has also been reported. 39 Hepato/splenomegaly in patients with Schnitzler syndrome (IgM monoclonal gammopathy, urticarial rash, arthralgia[bloodjournal.org] Clinical features : The most frequent manifestations include cutaneous purpura and urticaria; in many cases there are weakness and arthralgias.[kidneypathology.com]

  • Primary Amyloidosis

    Orthostatic hypotension can be severe and difficult to manage. Fitted waist-high elastic stockings and midodrine are helpful.[doi.org] X-rays did not show any skeletal osteolytic lesions. The final diagnosis was systemic AL amyloidosis IgG lambda-type BJ positive lambda.[bmcgastroenterol.biomedcentral.com] […] para-protein (IgM-κ is most common) at the dermoepidermal junction and in capillary walls which probably contributes to development of chronic urticaria, intermittent fever, arthralgia[doi.org]

  • Systemic Amyloidosis

    recurrent inflammation. 57 Supportive treatment of specific symptoms Although symptoms of dysautonomia are rare in AA amyloidosis, severe orthostatic hypotension may lead[ncbi.nlm.nih.gov] […] para-protein (IgM-κ is most common) at the dermoepidermal junction and in capillary walls which probably contributes to development of chronic urticaria, intermittent fever, arthralgia[doi.org] […] with AL amyloidosis, but AA amyloidosis has also been reported. 39 Hepato/splenomegaly in patients with Schnitzler syndrome (IgM monoclonal gammopathy, urticarial rash, arthralgia[bloodjournal.org]

  • Capillary Leak Syndrome

    . - A man aged 61 had recurrent attacks of severe shock.[ntvg.nl] A bone marrow aspiration showed 80% abnormal plasmocytes, confirming the diagnosis of myeloma. M‐component serum level was 18 g/l. Humeral lacunae were seen on an Xray.[ndt.oxfordjournals.org] The most common side effects of IL-11 are arthralgias and myalgias, fatigue, nausea, and headache.[cancerjournal.net]

  • Pure Autonomic Failure

    First, patients with PAF did not have severe urinary disturbances, which would lessen the risk of recurrent urinary infections, and they also did not have life threatening[jnnp.bmj.com] […] joints in hands and feet can also be involved usually bilateral painful contractures cause limited range of movement – an important cause of disability characteristic unique x-ray[dermnetnz.org] […] foreign body in the eye, increased lacrimation (tear production), blepharitis (inflammation of the eyelids), dry eye, ocular hyperaemia (red eye), eye pruritis (itching), arthralgia[sv.glosbe.com]

  • Autosomal Dominant Hereditary Sensory and Autonomic Neuropathy

    Severe autonomic dysfunctions occur: alacrymia (loss of tear secretion), dysphagia, hypothermia, orthostatic hypotension, loss of fungiform papillas on tongue.[tankonyvtar.hu] Complete hemogram, urinalysis, chest X-ray, fundoscopy, pure tone audiometry revealed no abnormality.[e-ijd.org] […] for 3/12 in four or more joints Minor criteria Current/historic Brighton score of 1, 2 or 3/9 (0, 1, 2, 3/9 if 50 years old) Arthralgia for minimum of 3 months in 1–3 joints[medical-dictionary.thefreedictionary.com]

  • Optic Nerve Edema-Splenomegaly Syndrome

    Complications such as severe orthostatic hypotension, recurrent infections or venous thromboses should be evaluated on the basis of resultant impairment. C.[secure.ssa.gov] Ankle arthralgias are common.[autoinflammatory-search.org] […] cavity (ascites), or around the lungs (pleural effusions), painless scars on bone x-ray (osteosclerosis), and an elevated platelet count (a blood cell responsible for clotting[rarediseases.org]

  • Kappa Chain Deficiency

    Orthostatic hypotension can be severe and difficult to manage. Fitted waist-high elastic stockings and midodrine are helpful.[cjasn.asnjournals.org] The bone marrow lesions can be visualize on x-ray as characteristic “punched out lesions” which leads to bone pain, osteoporosis, pathologic fractures, and hypercalcemia.[ucsdlabmed.wikidot.com] Arthralgia and conjunctivitis are frequently reported. Pyoderma, urinary tract infection, osteomyelitis/arthritis, and meningitis/encephalitis are less common.[emedicine.medscape.com]

  • Venlafaxine

    Effects of orthostatic hypotension on cognition in Parkinson disease. Neurology 2017, 88:17-24 Connolly S and others.[dizziness-and-balance.com] Repeated chest X-ray was normal. The patient was discharged to his home on day 12.[doi.org] Burstein, Aromatase inhibitor-associated arthralgia syndrome, The Breast, 10.1016/j.breast.2007.01.011, 16, 3, (223-234), (2007).[doi.org]

  • Autosomal Dominant Mental Retardation Type 5

    Observation of severe orthostatic hypotension in a patient whose plasma norepinephrine/dopamine ratio is much less than one supports the diagnosis.[massgeneral.org] Childhood x-rays show delayed carpal and tarsal ossification.[tsbvi.edu] […] arthritis (hip); [Limbs]; Flat femoral condyles; Recurrent patellar dislocation; Arthralgia/arthritis (knee, elbow, shoulder); Inability to supinate forearm; [Hands]; Arthralgia[findzebra.com]

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