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4,772 Possible Causes for Arthralgia, Splenomegaly, Susceptibility to Hematologic Malignancies Increased

  • Gaucher Disease

    CONCLUSION: HALS for GD patients with refractory hypersplenism and massive splenomegaly is safe and feasible in experienced hands.[ncbi.nlm.nih.gov] In addition to the classic manifestations, patients suffer from increased susceptibility to hematologic and nonhematologic malignancies.[ncbi.nlm.nih.gov] […] and EU Summary of Product Characteristics (SmPC) were evaluated with regard to frequency, drug-relatedness, severity, seriousness, duration, and timing of onset: headache, arthralgia[ncbi.nlm.nih.gov]

  • Common Variable Immunodeficiency

    Eighteen cases (69%) cases had coexistent splenomegaly with lower IgA levels (P .04) compared with the controls. Patients with low IgA levels ( 5%) (P .007).[ncbi.nlm.nih.gov] […] to infections, autoimmune diseases, hematologic malignancy, or death caused by infection in other family members should increase the provider’s index of suspicion for CVID[mdedge.com] Other findings less frequently reported included rash, arthralgias, myalgias, facial edema, and lymph node or liver test abnormalities, which can also occur in infectious[doi.org]

  • Hemochromatosis

    Regression on SF revealed significant associations: TS; male sex; age; GGT; transfusion units (positive); and splenomegaly (negative) (p 0.0001, 0.0016, 0.0281, 0.0025, 0.0001[ncbi.nlm.nih.gov] Symptoms greatly vary among patients and include fatigue, abdominal pain, arthralgias, impotence, decreased libido, diabetes, and heart failure.[ncbi.nlm.nih.gov] […] and its full clinical expression is seen in only a minority of patients. [9] In addition, any patient admitted to the hospital with an isolated case of asthenia or with arthralgia[emedicine.com]

    Missing: Susceptibility to Hematologic Malignancies Increased
  • Hepatitis

    Dehydration with drying of mucous membranes Telangiectasis (spider angiomata) and esophageal varices Jaundice Ascites Utricarial rashes Portal Hypertension Hepatomegaly and Splenomegaly[symptoma.com] ., fatigue, arthralgia, jaundice) in approximately one third of patients; however, the majority of patients are asymptomatic.[bestpractice.bmj.com] Mild splenomegaly occurs in 15 to 20% of patients. Jaundice usually peaks within 1 to 2 wk. Recovery phase: During this 2- to 4-wk period, jaundice fades.[merckmanuals.com]

    Missing: Susceptibility to Hematologic Malignancies Increased
  • Rheumatoid Arthritis

    It is extremely rare for RA to present as FS or develop after initially presenting as neutropaenia and splenomegaly.[ncbi.nlm.nih.gov] It can cause arthralgias and weakness in intrinsic muscles of the hand.[ncbi.nlm.nih.gov] Six weeks later, along with steroid dose reduction, the symptoms of arthralgia was observed, which was managed with methotrexate.[ncbi.nlm.nih.gov]

    Missing: Susceptibility to Hematologic Malignancies Increased
  • Adult-Onset Still Disease

    […] clinically by high spiking fever, polyarthralgia/arthritis, a salmon-pink evanescent rash, predominantly neutrophilic leucocytosis, lymphadenopathy, liver dysfunction, and splenomegaly[ncbi.nlm.nih.gov] Severe malaise, myalgia, arthralgia, and leukocytosis were present in every patient.[ncbi.nlm.nih.gov] The proposed criteria consisted of fever, arthralgia, typical rash, and leukocytosis as major, and sore throat, lymphadenopathy and/or splenomegaly, liver dysfunction, and[ncbi.nlm.nih.gov]

    Missing: Susceptibility to Hematologic Malignancies Increased
  • Infective Endocarditis

    This score includes clinical, epidemiological (male, fever, splenomegaly, clubbing, vascular disease and stroke) and biological criteria (Leucocytes 10,000/mm3, sedimentation[ncbi.nlm.nih.gov] A 64-year-old woman, without previous heart disease, presented with 6 weeks of fever, myalgias, and arthralgias.[ncbi.nlm.nih.gov] Additional findings may include splenomegaly, gallop or arrhythmia, pericardial or pleural rubs, rales, pallor, acute septic monoarticular arthritis or delirium.[symptoma.com]

    Missing: Susceptibility to Hematologic Malignancies Increased
  • Lupus Erythematosus

    […] keratoconjunctivitis sicca as well as more uncommon manifestations Haematologic manifestations, including cytopenias, thrombophilia, thromboembolic disease, lymphadenopathy and splenomegaly[els.net] MUSCULOSKELETAL SYSTEM Musculoskeletal involvement is present in 95% of patients with SLE and manifests as arthralgias, myalgias, or nonerosive inflammatory arthritis. 10[aafp.org] Enlargement of the spleen (splenomegaly) occurs in about 10% of people.[msdmanuals.com]

    Missing: Susceptibility to Hematologic Malignancies Increased
  • Leukemia

    Five features were present in 50% of children: hepatomegaly (64%), splenomegaly (61%), pallor (54%), fever (53%) and bruising (52%).[ncbi.nlm.nih.gov] Other side effects included rashes in 4%, arthralgias in 5%, and fatigue in 3%.[web.archive.org] Leukemia is usually associated with anemia, fever, hemorrhagic episodes, and splenomegaly.[icd9data.com]

    Missing: Susceptibility to Hematologic Malignancies Increased
  • Myeloproliferative Disease

    CML: demonstrates increased production of neutrophils and marked splenomegaly.[ncbi.nlm.nih.gov] Arthralgia and gout occur secondary to hyperuricemia.[symptoma.com] Both patients were suffering from thrombocytopenia and splenomegaly and underwent splenectomy. The weight of the spleen specimens was more than 2000 g.[ncbi.nlm.nih.gov]

    Missing: Susceptibility to Hematologic Malignancies Increased

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