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10 Possible Causes for Arthralgia, Susceptibility to Hematologic Malignancies Increased, Thrombocytopenia

  • Gaucher Disease

    KEYWORDS: GBA gene mutation; Gaucher cells; thrombocytopenia; type 1 Gaucher disease[ncbi.nlm.nih.gov] In addition to the classic manifestations, patients suffer from increased susceptibility to hematologic and nonhematologic malignancies.[ncbi.nlm.nih.gov] […] and EU Summary of Product Characteristics (SmPC) were evaluated with regard to frequency, drug-relatedness, severity, seriousness, duration, and timing of onset: headache, arthralgia[ncbi.nlm.nih.gov]

  • Common Variable Immunodeficiency

    Thrombocytopenia was only found in this cluster (36% of cases, manifested as Immune Thrombocytopenia (ITP) or Evans syndrome).[ncbi.nlm.nih.gov] […] to infections, autoimmune diseases, hematologic malignancy, or death caused by infection in other family members should increase the provider’s index of suspicion for CVID[mdedge.com] Other findings less frequently reported included rash, arthralgias, myalgias, facial edema, and lymph node or liver test abnormalities, which can also occur in infectious[doi.org]

  • Autosomal Dominant Thrombocytopenia 5

    Mutations in the 5′ UTR of ANKRD26, the ankirin repeat domain 26 gene, cause an autosomal-dominant form of inherited thrombocytopenia, THC2.[repub.eur.nl] THC5 is an autosomal dominant disorder, associated with an increased susceptibility to the development of hematologic and solid malignancies.[uniprot.org] Rheumatoid factor and antinuclear antibody tests should be ordered if a patient has significant prominent arthralgia or arthritis.[aafp.org]

  • Splenic Subcapsular Hematoma

    After the diagnosis of brucellosis had been confirmed by blood culture and serology, progressive thrombocytopenia developed in spite of appropriate antibiotic administration[read.qxmd.com] However, splenectomy should be avoided if possible, particularly in children, the elderly, and patients with hematologic malignancy, to avoid the resulting permanent susceptibility[merckmanuals.com] He reported no previous trauma, fever, headache, fatigue, myalgia, arthralgia, skin alterations, or comorbidities.[semanticscholar.org]

  • Parainfluenza Virus

    On admission, he had relative lymphopenia, thrombocytopenia, and an elevated creatine phosphokinase. His chest x-ray showed no focal segmental or lobar infiltrates.[ncbi.nlm.nih.gov] malignancy (HM) patients because of their immunocompromised status and susceptibility to lower respiratory tract infections.[ncbi.nlm.nih.gov] In addition, systemic symptoms such as myalgias and arthralgias were not seen in these patients, unlike patients with cytomegalovirus.[nejm.org]

  • Monocytopenia with Susceptibility to Infections

    Treatment advances in posttransplant lymphoproliferative disease Evaluation of thrombocytopenia in the acute coronary syndrome Hb Baden structural and functional characterization[books.google.com] Most of the patients present with hematological abnormalities (cytopenias, early-onset myeloid malignancies) and an increased susceptibility to opportunistic infections [[bmcpulmmed.biomedcentral.com] Since approximately one third of patients may have rheumatologic symptoms, such as erythema nodosum, panniculitis, or arthralgias, rheumatologists may expect to encounter[link.springer.com]

  • Common Variable Immunodeficiency Type 4

    Autoimmune disorders (eg, autoimmune thrombocytopenia, autoimmune hemolytic or pernicious anemia, SLE, Addison disease, thyroiditis, RA, alopecia areata) can occur, as can[merckmanuals.com] […] to infections, autoimmune diseases, hematologic malignancy, or death caused by infection in other family members should increase the provider’s index of suspicion for CVID[mdedge.com] arthralgia, symmetric polyarthritis polyarthralgia polyarthralgia, oligoarthritis, clubbig epiphyseal overgrowth, contractures, intermittent or chronic arthritis, clubbing[ufrgs.br]

  • Methylprednisolone

    The patient had level I (definite) evidence for DITP, 1 that is, onset of thrombocytopenia after exposure to MP, spontaneous recovery after MP withdrawal, and recurrent thrombocytopenia[bloodjournal.org] : Leukocytosis (transient), malignant neoplasm (secondary), petechia Hepatic: Hepatomegaly, increased liver enzymes, increased serum transaminases Hypersensitivity: Anaphylactoid[drugs.com] Henoch-Schönlein purpura is an immunoglobulin A-mediated, small vascular inflammatory disease that can be associated with palpable purpura, arthralgia, abdominal pain, or[ncbi.nlm.nih.gov]

  • Common Variable Immunodeficiency Type 11

    Immunosuppressive therapy was conducted in 7 patients with autoimmune thrombocytopenia and anemia.[f1000research.com] […] to infections, autoimmune diseases, hematologic malignancy, or death caused by infection in other family members should increase the provider’s index of suspicion for CVID[mdedge.com] This initial presentation is followed by recurrent febrile episodes with splenomegaly and sometimes hematologic disturbances, arthralgias, or myalgias.[mendelian.co]

  • Familial Candidiasis Type 2

    In infancy, recurrent pyogenic infections, eczema, thrombocytopenia, excessive bleeding. IgG levels remain normal.[kumc.edu] . • The patients who are on immunosuppressive drug regimens or who have HIV infection, cancer, or hematologic malignancies have an increased susceptibility to oral candidiasis[slideshare.net] Acute genitocrural intertrigo with accompanying fever, fatigue, sore throat, and arthralgia may be a component of an acute febrile illness.[aafp.org]

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