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70 Possible Causes for Arthralgia, Thickening of the Mitral Valve Leaflets

  • Mucopolysaccharidosis

    The most frequently reported adverse reactions included: chills, vomiting, nausea, arthralgia, diarrhea, tachycardia, abdominal pain, blood pressure increased, and oxygen[biomarin.com]

  • Streptococcal Infection

    We report the case of an immunocompetent child who showed monoarticular arthritis and fever, preceded by pharyngitis and arthralgias.[ncbi.nlm.nih.gov] Chronic rheumatic heart disease mostly affects the mitral valve, which can become thickened with calcification of the leaflets, often causing fusion of the commissures and[en.wikipedia.org] The minor criteria include arthralgia, fever, elevated erythrocyte sedimentation rate, elevated C-reactive protein, or a prolonged PR interval [ 1 ].[casesjournal.biomedcentral.com]

  • Mucopolysaccharidosis 1 H-S

    Less commonly reported infusion reactions included nausea, diarrhea, feeling hot or cold, vomiting, pruritus, arthralgia and urticaria.[aldurazyme.com] Progressive thickening and stiffening of the valve leaflets can lead to mitral and aortic regurgitation, which may become hemodynamically significant in the later stages of[ncbi.nlm.nih.gov]

  • Infective Endocarditis

    A 64-year-old woman, without previous heart disease, presented with 6 weeks of fever, myalgias, and arthralgias.[ncbi.nlm.nih.gov] […] history of endocarditis history of illegal drug use mitral valve prolapse and valve regurgitation (leaking) and/or thickened valve leaflets The risk of infective endocarditis[healthline.com] Complaints of low back pain, pain in the joints (arthralgia) or in one or more muscles (myalgia) are common.[rarediseases.org]

  • Rheumatic Heart Disease

    "Minor" criteria include arthralgia (joint pain - not arthritis, which implies inflammation of the joint), fever, bloodwork suggestive of increased inflammation (elevated[childrensheartinstitute.org] Echocardiography evaluation showed thickened aortic and mitral valve leaflets with mild to moderate degree of mitral regurgitation.[ncbi.nlm.nih.gov] Minor manifestations of the disease are fever, arthralgia, long PR interval, and elevated acute phase reactant, elevated levels of leucocytes and presence of C-reactive protein[symptoma.com]

  • Endocarditis

    Complaints of low back pain, pain in the joints (arthralgia) or in one or more muscles (myalgia) are common.[rarediseases.org] Patients most at risk of developing bacterial endocarditis include those who have: Acquired valve disease (for example, rheumatic heart disease) including mitral valve prolapse[my.clevelandclinic.org] Abdominal pain and nausea, vomiting, diarrhea, arthralgia, and myalgia. Overt Symptoms. Chest pain. Heart failure with dyspnea. Diagnostic tests.[micunursing.com]

  • Lupus Erythematosus

    MUSCULOSKELETAL SYSTEM Musculoskeletal involvement is present in 95% of patients with SLE and manifests as arthralgias, myalgias, or nonerosive inflammatory arthritis. 10[aafp.org] (b) Two-dimensional echocardiogram demonstrates a thickened mitral valve leaflet (arrow). (Case courtesy of Catherine M.[pubs.rsna.org] Antimalarials, e.g., hydroxychloroquine, can use to treat arthralgia and skin disease.[ncbi.nlm.nih.gov]

  • Bacterial Endocarditis

    Patients with this type experience an insidious onset of nonspecific symptoms such as low-grade fever, fatigue, anorexia, weight loss, malaise, night sweats, chills, and arthralgia[symptoma.com] Patients most at risk of developing bacterial endocarditis include those who have: Acquired valve disease (for example, rheumatic heart disease) including mitral valve prolapse[my.clevelandclinic.org] […] had musculoskeletal involvement during the course of the disease and in 52 of these (62%) the involvement was present among other symptoms at the diagnosis and included: arthralgia[scielo.br]

  • Rheumatic Fever

    High ASO titers, arthralgia, and combination of high ASO titers with arthralgia are the main presenting symptoms in the group with a different diagnosis.[ncbi.nlm.nih.gov] […] regurgitation and/or significant aortic regurgitation AND a thickened mitral valve and/or elbow deformity of the anterior mitral leaflet Probable Comes from a population[doi.org] Mitral valvulitis can occur causing thickening of the leaflets. A murmur is created by increased blood flow across the thickened mitral valve.[healio.com]

  • Necrotizing Vasculitis

    Within 14 days of interferon-alpha therapy (3 x 3 million IU/ml/week), purpuric skin lesions disappeared as well as fatigue and arthralgia; 9 months after initiation of therapy[ncbi.nlm.nih.gov] Echocardiogram revealed significant thickening of aortic root, aortic cusps, and anterior mitral valve leaflet, with severe aortic regurgitation that required aortic valve[ncbi.nlm.nih.gov] […] vasculitis Immunoglobulins and protein electrophoresis Arthralgia, bone lesions, defective immune status Diagnosis* Rheumatoid factor Arthralgia, myalgia Diagnosis* Tissue[aafp.org]

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