Create issue ticket

11 Possible Causes for Ascending Numbness and Weakness, Paresthesia of the Upper Extremity

  • Hereditary ATTR Amyloidosis

    Patisiran is an investigational RNA interference (RNAi) therapeutic in development for the treatment of hereditary ATTR (hATTR) amyloidosis, a progressive disease associated with significant disability, morbidity, and mortality. Here we describe the rationale and design of the Phase 3 APOLLO study, a randomized,[…][]

  • Myelopathy

    […] lower limb weakness.[] Other symptoms of cervical spondylotic myelopathy include: Pain in the neck, subscapular area, or shoulder Numbness or paresthesia in the upper extremities Sensory changes[] […] in the upper extremities.[]

  • Guillain-Barré Syndrome

    It’s also called: Acute Inflammatory Demyelinating Polyneuropathy Landry’s Ascending Paralysis GBS is characterized by the rapid onset of numbness , weakness, and often paralysis[] CASE REPORT A 54-year-old man presented with lower left facial palsy and paresthesia of his extremities, following an upper respiratory tract infection.[] The generally accepted criteria for the diagnosis of Guillain–Barré syndrome include: progressive, ascending weakness of more than two extremities, areflexia and numbness[]

  • Neurosarcoidosis

    A subacute radiculoneuropathy resembling Guillain Barré syndrome has also been noted, in which patients develop an ascending numbness and weakness which can sometimes become[] During this presentation, the patient experienced right leg paresthesias, slurred speech, right facial droop, and right upper and lower extremity weakness 2 hours after the[]

  • Decompression Sickness

    weakness or paralysis; girdling abdominal or chest pain.[] extremities.[] weakness or paralysis in the legs Urinary incontinence and fecal incontinence Girdling (also referred to as girdle, banding, or tightening feeling) around the abdominal region[]

  • Subacute Transverse Myelitis

    A 56-year-old man was admitted to the hospital reporting 5 months of progressive ascending lower extremity weakness and numbness, inability to walk, bowel incontinence,urinary[] Six patients (40%) had symmetric sensory and motor dysfunction of their upper or lower extremities and bladder dysfunction, thereby meeting the criteria for ATM during their[] BACKGROUND: A 74-year-old man presented with rapid onset of weakness, numbness, and tingling in his legs, with symptoms ascending to his hands and forearms within days.[]

  • Polyneuropathy

    Symptoms Tingling Numbness Loss of sensation in the arms and legs Symmetrical weakness that usually affects the lower limbs first, and rapidly progresses in an ascending fashion[] Deep tendon reflexes were absent in the upper and lower extremities.[] extremities.[]

  • Cervical Cord Compression

    Pain in the upper extremity, particularly the shoulder, either described as stabbing or dull can appear along with hand numbness.[] Clonus of the upper or lower extremities may be present as well. A positive babinski sign suggests advanced disease.[] When these do arise, the most common are neck pain and manifestations of radiculopathy (nerve root irritation or compression resulting in upper extremity symptoms) or myelopathy[]

  • Diabetic Pseudotabes

    […] poorly myelinated; primarily sensory and autonomic; symptoms include burning, tingling, numbness, pain heavily myelinated; primarily motor and sensory; symptoms include weakness[] When the ascent reaches the upper tibia, the hands begin to become involved.[] , vibratory and position sense loss, numbness, areflexia Acute idiopathic inflammatory polyneuropathy Primarily demyelinating motor polyneuropathy Ascending paralysis( IMPORTANT[]

  • Spinal Demyelination

    As the condition progresses, there can be sensory change, as well (usually numbness and tingling), but the picture is usually dominated by flaccid weakness.[] At that time she had spastic upper extremities diparesis, more pronounced in the left arm, and spastic paraplegia, with brisk deep tendon reflexes and bilateral positive Babinski[] Although the most common presentation is with an ascending paralysis, rarely, it can begin by affecting cranial muscles.[]

Further symptoms