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288 Possible Causes for Ascites, Hypersplenism, Splenomegaly

  • Portal Hypertension

    We performed LS in 83 patients with massive splenomegaly ( 30 cm) secondary to portal hypertension and liver cirrhosis.[ncbi.nlm.nih.gov] The patient underwent splenectomy for hypersplenism and portal hypertension; the weight of his spleen was 2,400 g.[ncbi.nlm.nih.gov] The serum-ascites albumin gradient value of 1.9 g/dL and the total protein level in the ascites of 3.1 g/dL indicated the ascites to have been caused by portal hypertension[ncbi.nlm.nih.gov]

  • Portal Vein Thrombosis

    She had splenomegaly and thrombocytopenia. Investigations did not reveal any prothrombotic disorder.[ncbi.nlm.nih.gov] Here, we report the case of a 67-year-old woman who developed thrombocytopenia as a result of hypersplenism.[ncbi.nlm.nih.gov] Peritoneal tuberculosis can present with unusual manifestations such as portal vein thrombosis and transudative ascites causing a diagnostic dilemma.[ncbi.nlm.nih.gov]

  • Primary Myelofibrosis

    Here we report a rare case of PMF with anemia, small bowel obstruction and ascites due to extramedullary hematopoiesis and portal hypertension.[ncbi.nlm.nih.gov] We report a patient with very advanced myelofibrosis and huge splenomegaly who showed a complete hematological response to low dose thalidomide with reversal of splenomegaly[ncbi.nlm.nih.gov] Anaemia (may occur due to ineffective erythropoiesis, erythroid hypoplasia and hypersplenism) may cause fatigue, weakness and dyspnoea.[patient.info]

  • Hepatic Vein Occlusion

    The syndrome may present in an acute form with upper abdominal pain, abdominal swelling, ascites and tender hepatomegaly or in a chronic form, mimicking cirrhotic ascites.[ncbi.nlm.nih.gov] Physical examination was remarkable for splenomegaly and mild right upper quadrant tenderness.[members.sirweb.org] Chronic PVT may present with sequelae of portal hypertension, most commonly esophageal, and gastric variceal bleeding in the acute hospital setting, although hypersplenism[clinicaladvisor.com]

  • Wilson Disease

    For patients presenting with ascites, diuretics are the treatment of choice.[ncbi.nlm.nih.gov] She had no hepatomegaly and no splenomegaly. Breast and pubic hair development was concomitant with Tanner stage 4.[ncbi.nlm.nih.gov] […] of the brain, a brownish ring (Kayser-Fleischer ring) at the outer margin of the cornea caused by deposition of copper in the Descemet membrane, cirrhosis of the liver, splenomegaly[whonamedit.com]

  • Amyloidosis

    We report here a case of portal hypertension, ascites, and severe intrahepatic cholestasis as the initial presentation of hepatic amyloidosis and multiple myeloma, which followed[ncbi.nlm.nih.gov] PATIENT CONCERNS: We reported two cases with ApoA-1 amyloidosis, a 64-year-old man suffering from nephrotic syndrome and a 40-year-old man with nephrotic syndrome and splenomegaly[ncbi.nlm.nih.gov] Quite often the pericardiac exudate and ascites is found in patients with amiloidozy hearts.[medicine-for-you.com]

  • Familial Myelofibrosis

    Symptomatic portal hypertension (e.g. ascites, bleeding varices). Severe catabolic symptoms including cachexia (Evidence level 2, Grade C).[onlinelibrary.wiley.com] The typical clinical features include marked splenomegaly, progressive anemia, . . .[nejm.org] BESREMi is approved as first-line monotherapy in adults for the treatment of Polycythaemia vera (PV) without symptomatic splenomegaly BESREMi showed high and durable hematologic[aoporphan.hu]

  • Presinusoidal Portal Hypertension

    […] stage characterized by ascites, together with increasing jaundice and anemia.[annals.org] Physical examination was unremarkable except for splenomegaly and skin lesions.[ncbi.nlm.nih.gov] He described three stages: the anemic stage in which hypersplenism was the only finding; the transitional stage characterized by jaundice and disturbed gastrointestinal function[annals.org]

  • Splenic Vein Thrombosis

    She has no ascites, the nutritional state has normalized and hepatic laboratory findings have returned to normal values.[ncbi.nlm.nih.gov] Seven of 9 patients (78 %) with massive splenomegaly ( 20 cm) developed PSVT compared with 4 of 13 patients (31 %) with moderate splenomegaly (15-20 cm) and 6 of 45 patients[ncbi.nlm.nih.gov] MATERIAL AND METHODS: Sixteen patients with severe hypersplenism underwent PSE between March 2005 and April 2008.[ncbi.nlm.nih.gov]

  • Liver Cirrhosis

    The serum-ascites albumin gradient value of 1.9 g/dL and the total protein level in the ascites of 3.1 g/dL indicated the ascites to have been caused by portal hypertension[ncbi.nlm.nih.gov] We performed LS in 83 patients with massive splenomegaly ( 30 cm) secondary to portal hypertension and liver cirrhosis.[ncbi.nlm.nih.gov] Lusutrombopag, a small molecule thrombopoietin receptor agonist, has been approved for the treatment of chronic liver disease-associated thrombocytopenia due to hypersplenism[ncbi.nlm.nih.gov]

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